FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106182413> ?p ?o ?g. }

• W2106182413 endingPage "1329" @default.
• W2106182413 startingPage "1322" @default.
• W2106182413 abstract "Lovastatin has been shown to reduce cholesterol esterification in cholesterol-loaded human macrophages. Surprisingly, in nonloaded macrophages, lovastatin produces the opposite effect, lowering free cholesterol and increasing cholesteryl ester levels, as measured by high-performance liquid chromatography. In cholesterol-loaded cells, lovastatin reduced the cholesteryl esters of unsaturated but not those of saturated fatty acids. In nonloaded cells, by contrast, the cholesteryl esters of unsaturated fatty acids tended to increase after lovastatin treatment. Total (free plus esterified) cellular cholesterol content in nonloaded cells fell by 18% with 12-micromol/L lovastatin treatment but did not change in cholesterol-loaded cells. Lovastatin had no effect on the binding or uptake of acetylated low density lipoprotein, acyl coenzyme A:cholesterol acyltransferase (ACAT) activity, the secretion of [3H]cholesterol into the medium, or lysosomal hydrolysis of cholesteryl esters. Apolipoprotein (apo) E mRNA levels increased but apoE secretion into the medium decreased with lovastatin treatment in both cholesterol-loaded and nonloaded cells. Cholesterol of exogenous origin has been shown to pass via the cell membrane before its esterification by ACAT. We postulate that this is not the case for endogenous cholesterol, which may have direct access to ACAT. Our findings therefore suggest that lovastatin hinders the delivery of intracellular cholesterol to the plasma membrane, resulting in increased free cholesterol and lower levels of cholesteryl ester in cholesterol-loaded cells. In nonloaded cells, virtually all cholesterol is of endogenous origin and is normally translocated to the cell membrane. Lovastatin prevents this process, thus shunting newly synthesized cholesterol toward esterification and leading to an increase in the concentration of cholesteryl esters, even in the face of a drop in total and free cholesterol levels. Intracellular apoE may play a role in this process." @default.
• W2106182413 created "2016-06-24" @default.
• W2106182413 creator A5021746678 @default.
• W2106182413 creator A5027046285 @default.
• W2106182413 creator A5030699960 @default.
• W2106182413 creator A5042316631 @default.
• W2106182413 creator A5058297665 @default.
• W2106182413 date "1998-08-01" @default.
• W2106182413 modified "2023-09-25" @default.
• W2106182413 title "Differential Effects of Lovastatin on the Trafficking of Endogenous and Lipoprotein-Derived Cholesterol in Human Monocyte–Derived Macrophages" @default.
• W2106182413 cites W1040626293 @default.
• W2106182413 cites W1277224710 @default.
• W2106182413 cites W1523931486 @default.
• W2106182413 cites W1537363506 @default.
• W2106182413 cites W1594886649 @default.
• W2106182413 cites W1775749144 @default.
• W2106182413 cites W1940775645 @default.
• W2106182413 cites W1965705262 @default.
• W2106182413 cites W1965760487 @default.
• W2106182413 cites W1970259339 @default.
• W2106182413 cites W1987820165 @default.
• W2106182413 cites W1993025383 @default.
• W2106182413 cites W1998329673 @default.
• W2106182413 cites W2004194946 @default.
• W2106182413 cites W2012665763 @default.
• W2106182413 cites W2016678257 @default.
• W2106182413 cites W2023312128 @default.
• W2106182413 cites W2039813201 @default.
• W2106182413 cites W2042712943 @default.
• W2106182413 cites W2049765270 @default.
• W2106182413 cites W2051018092 @default.
• W2106182413 cites W2061768094 @default.
• W2106182413 cites W2064649898 @default.
• W2106182413 cites W2070450491 @default.
• W2106182413 cites W2071124826 @default.
• W2106182413 cites W2080754482 @default.
• W2106182413 cites W2081038112 @default.
• W2106182413 cites W2108668893 @default.
• W2106182413 cites W2119132136 @default.
• W2106182413 cites W2120626817 @default.
• W2106182413 cites W2324712847 @default.
• W2106182413 cites W4236017105 @default.
• W2106182413 cites W4294216491 @default.
• W2106182413 doi "https://doi.org/10.1161/01.atv.18.8.1322" @default.
• W2106182413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9714140" @default.
• W2106182413 hasPublicationYear "1998" @default.
• W2106182413 type Work @default.
• W2106182413 sameAs 2106182413 @default.
• W2106182413 citedByCount "29" @default.
• W2106182413 countsByYear W21061824132021 @default.
• W2106182413 crossrefType "journal-article" @default.
• W2106182413 hasAuthorship W2106182413A5021746678 @default.
• W2106182413 hasAuthorship W2106182413A5027046285 @default.
• W2106182413 hasAuthorship W2106182413A5030699960 @default.
• W2106182413 hasAuthorship W2106182413A5042316631 @default.
• W2106182413 hasAuthorship W2106182413A5058297665 @default.
• W2106182413 hasBestOaLocation W21061824131 @default.
• W2106182413 hasConcept C126322002 @default.
• W2106182413 hasConcept C134018914 @default.
• W2106182413 hasConcept C185592680 @default.
• W2106182413 hasConcept C2776448209 @default.
• W2106182413 hasConcept C2778163477 @default.
• W2106182413 hasConcept C2779134260 @default.
• W2106182413 hasConcept C2780072125 @default.
• W2106182413 hasConcept C2780940807 @default.
• W2106182413 hasConcept C37002583 @default.
• W2106182413 hasConcept C55493867 @default.
• W2106182413 hasConcept C57089818 @default.
• W2106182413 hasConcept C62746215 @default.
• W2106182413 hasConcept C71924100 @default.
• W2106182413 hasConcept C86803240 @default.
• W2106182413 hasConceptScore W2106182413C126322002 @default.
• W2106182413 hasConceptScore W2106182413C134018914 @default.
• W2106182413 hasConceptScore W2106182413C185592680 @default.
• W2106182413 hasConceptScore W2106182413C2776448209 @default.
• W2106182413 hasConceptScore W2106182413C2778163477 @default.
• W2106182413 hasConceptScore W2106182413C2779134260 @default.
• W2106182413 hasConceptScore W2106182413C2780072125 @default.
• W2106182413 hasConceptScore W2106182413C2780940807 @default.
• W2106182413 hasConceptScore W2106182413C37002583 @default.
• W2106182413 hasConceptScore W2106182413C55493867 @default.
• W2106182413 hasConceptScore W2106182413C57089818 @default.
• W2106182413 hasConceptScore W2106182413C62746215 @default.
• W2106182413 hasConceptScore W2106182413C71924100 @default.
• W2106182413 hasConceptScore W2106182413C86803240 @default.
• W2106182413 hasIssue "8" @default.
• W2106182413 hasLocation W21061824131 @default.
• W2106182413 hasLocation W21061824132 @default.
• W2106182413 hasOpenAccess W2106182413 @default.
• W2106182413 hasPrimaryLocation W21061824131 @default.
• W2106182413 hasRelatedWork W1984624793 @default.
• W2106182413 hasRelatedWork W2002329577 @default.
• W2106182413 hasRelatedWork W2006732084 @default.
• W2106182413 hasRelatedWork W2025648868 @default.
• W2106182413 hasRelatedWork W2055794996 @default.
• W2106182413 hasRelatedWork W2106182413 @default.
• W2106182413 hasRelatedWork W2120083869 @default.
• W2106182413 hasRelatedWork W2150248304 @default.

• next