Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106183057> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2106183057 endingPage "5" @default.
- W2106183057 startingPage "5913" @default.
- W2106183057 abstract "NAD(P)H:quinone oxidoreductase 1 (NQO1) is a flavoprotein that catalyzes the metabolic detoxification of quinones and their derivatives. This protects cells against quinone-induced oxidative stress, cytotoxicity, and mutagenicity. C57BL6 NQO1-/- mice, deficient in NQO1 RNA and protein, were generated in our laboratory. To investigate the role of NQO1 in chemical carcinogenesis, the dorsal skin of NQO1-deficient (NQO1-/-) and wild-type (NQO1+/+) mice were treated with a single dose of benzo(a)pyrene, followed by twice weekly applications of phorbol-12-myristate-13-acetate. The NQO1-/- mice showed a much higher frequency of skin tumor development when compared with their wild-type littermates. Interestingly, the male NQO1-/- mice were slower to develop skin tumors than their NQO1-/- female littermates. Histological analysis of the NQO1-/- tumors showed proliferative activity. These results demonstrate that NQO1 acts as an endogenous factor in protection against benzo(a)pyrene carcinogenicity." @default.
- W2106183057 created "2016-06-24" @default.
- W2106183057 creator A5024251213 @default.
- W2106183057 creator A5027903995 @default.
- W2106183057 creator A5028376389 @default.
- W2106183057 creator A5058060903 @default.
- W2106183057 creator A5062333741 @default.
- W2106183057 creator A5071625723 @default.
- W2106183057 date "2000-11-01" @default.
- W2106183057 modified "2023-10-16" @default.
- W2106183057 title "NAD(P)H:quinone oxidoreductase 1 deficiency increases susceptibility to benzo(a)pyrene-induced mouse skin carcinogenesis." @default.
- W2106183057 cites W1486158855 @default.
- W2106183057 cites W1579645917 @default.
- W2106183057 cites W1881840670 @default.
- W2106183057 cites W1982805396 @default.
- W2106183057 cites W1987355375 @default.
- W2106183057 cites W2009373556 @default.
- W2106183057 cites W2013092934 @default.
- W2106183057 cites W2017026249 @default.
- W2106183057 cites W2020178430 @default.
- W2106183057 cites W2053821985 @default.
- W2106183057 cites W2094622705 @default.
- W2106183057 cites W2094755318 @default.
- W2106183057 cites W2094779562 @default.
- W2106183057 cites W2103113315 @default.
- W2106183057 cites W2120969858 @default.
- W2106183057 cites W2128279248 @default.
- W2106183057 cites W2130638014 @default.
- W2106183057 cites W2172159364 @default.
- W2106183057 cites W2422491939 @default.
- W2106183057 cites W36679969 @default.
- W2106183057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11085502" @default.
- W2106183057 hasPublicationYear "2000" @default.
- W2106183057 type Work @default.
- W2106183057 sameAs 2106183057 @default.
- W2106183057 citedByCount "38" @default.
- W2106183057 countsByYear W21061830572013 @default.
- W2106183057 countsByYear W21061830572014 @default.
- W2106183057 countsByYear W21061830572015 @default.
- W2106183057 countsByYear W21061830572017 @default.
- W2106183057 countsByYear W21061830572018 @default.
- W2106183057 countsByYear W21061830572019 @default.
- W2106183057 countsByYear W21061830572020 @default.
- W2106183057 countsByYear W21061830572022 @default.
- W2106183057 countsByYear W21061830572023 @default.
- W2106183057 crossrefType "journal-article" @default.
- W2106183057 hasAuthorship W2106183057A5024251213 @default.
- W2106183057 hasAuthorship W2106183057A5027903995 @default.
- W2106183057 hasAuthorship W2106183057A5028376389 @default.
- W2106183057 hasAuthorship W2106183057A5058060903 @default.
- W2106183057 hasAuthorship W2106183057A5062333741 @default.
- W2106183057 hasAuthorship W2106183057A5071625723 @default.
- W2106183057 hasConcept C104317684 @default.
- W2106183057 hasConcept C114246631 @default.
- W2106183057 hasConcept C153911025 @default.
- W2106183057 hasConcept C178790620 @default.
- W2106183057 hasConcept C181199279 @default.
- W2106183057 hasConcept C185592680 @default.
- W2106183057 hasConcept C2776151105 @default.
- W2106183057 hasConcept C2777538855 @default.
- W2106183057 hasConcept C2778951431 @default.
- W2106183057 hasConcept C55493867 @default.
- W2106183057 hasConcept C555283112 @default.
- W2106183057 hasConcept C75520062 @default.
- W2106183057 hasConcept C86803240 @default.
- W2106183057 hasConceptScore W2106183057C104317684 @default.
- W2106183057 hasConceptScore W2106183057C114246631 @default.
- W2106183057 hasConceptScore W2106183057C153911025 @default.
- W2106183057 hasConceptScore W2106183057C178790620 @default.
- W2106183057 hasConceptScore W2106183057C181199279 @default.
- W2106183057 hasConceptScore W2106183057C185592680 @default.
- W2106183057 hasConceptScore W2106183057C2776151105 @default.
- W2106183057 hasConceptScore W2106183057C2777538855 @default.
- W2106183057 hasConceptScore W2106183057C2778951431 @default.
- W2106183057 hasConceptScore W2106183057C55493867 @default.
- W2106183057 hasConceptScore W2106183057C555283112 @default.
- W2106183057 hasConceptScore W2106183057C75520062 @default.
- W2106183057 hasConceptScore W2106183057C86803240 @default.
- W2106183057 hasIssue "21" @default.
- W2106183057 hasLocation W21061830571 @default.
- W2106183057 hasOpenAccess W2106183057 @default.
- W2106183057 hasPrimaryLocation W21061830571 @default.
- W2106183057 hasRelatedWork W1970972396 @default.
- W2106183057 hasRelatedWork W1996389707 @default.
- W2106183057 hasRelatedWork W2013121887 @default.
- W2106183057 hasRelatedWork W2021962651 @default.
- W2106183057 hasRelatedWork W2096202334 @default.
- W2106183057 hasRelatedWork W2106183057 @default.
- W2106183057 hasRelatedWork W2120969858 @default.
- W2106183057 hasRelatedWork W2744121398 @default.
- W2106183057 hasRelatedWork W3046140696 @default.
- W2106183057 hasRelatedWork W4210695390 @default.
- W2106183057 hasVolume "60" @default.
- W2106183057 isParatext "false" @default.
- W2106183057 isRetracted "false" @default.
- W2106183057 magId "2106183057" @default.
- W2106183057 workType "article" @default.