FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106183132> ?p ?o ?g. }

• W2106183132 endingPage "193" @default.
• W2106183132 startingPage "176" @default.
• W2106183132 abstract "The acyl-CoA dehydrogenases (ACADs) are enzymes that catalyze the α,β-dehydrogenation of acyl-CoA esters in fatty acid and amino acid catabolism. Eleven ACADs are now recognized in the sequenced human genome, and several homologs have been reported from bacteria, fungi, plants, and nematodes. We performed a systematic comparative genomic study, integrating homology searches with methods of phylogenetic reconstruction, to investigate the evolutionary history of this family. Sequence analyses indicate origin of the family in the common ancestor of Archaea, Bacteria, and Eukaryota, illustrating its essential role in the metabolism of early life. At least three ACADs were already present at that time: ancestral glutaryl-CoA dehydrogenase (GCD), isovaleryl-CoA dehydrogenase (IVD), and ACAD10/11. Two gene duplications were unique to the eukaryotic domain: one resulted in the VLCAD and ACAD9 paralogs and another in the ACAD10 and ACAD11 paralogs. The overall patchy distribution of specific ACADs across the tree of life is the result of dynamic evolution that includes numerous rounds of gene duplication and secondary losses, interdomain lateral gene transfer events, alteration of cellular localization, and evolution of novel proteins by domain acquisition. Our finding that eukaryotic ACAD species are more closely related to bacterial ACADs is consistent with endosymbiotic origin of ACADs in eukaryotes and further supported by the localization of all nine previously studied ACADs in mitochondria." @default.
• W2106183132 created "2016-06-24" @default.
• W2106183132 creator A5020392576 @default.
• W2106183132 creator A5038792936 @default.
• W2106183132 creator A5077361345 @default.
• W2106183132 date "2009-07-29" @default.
• W2106183132 modified "2023-10-06" @default.
• W2106183132 title "Acyl-CoA Dehydrogenases: Dynamic History of Protein Family Evolution" @default.
• W2106183132 cites W1497707727 @default.
• W2106183132 cites W1554071793 @default.
• W2106183132 cites W1570032463 @default.
• W2106183132 cites W15748964 @default.
• W2106183132 cites W1587032610 @default.
• W2106183132 cites W1610514370 @default.
• W2106183132 cites W1612239140 @default.
• W2106183132 cites W1974739739 @default.
• W2106183132 cites W1978474183 @default.
• W2106183132 cites W1979697790 @default.
• W2106183132 cites W1997063721 @default.
• W2106183132 cites W2005974395 @default.
• W2106183132 cites W2009337206 @default.
• W2106183132 cites W2017414485 @default.
• W2106183132 cites W2017578566 @default.
• W2106183132 cites W2019665485 @default.
• W2106183132 cites W2023932848 @default.
• W2106183132 cites W2030966943 @default.
• W2106183132 cites W2039359605 @default.
• W2106183132 cites W2040879926 @default.
• W2106183132 cites W2043511247 @default.
• W2106183132 cites W2051917428 @default.
• W2106183132 cites W2058238600 @default.
• W2106183132 cites W2062018285 @default.
• W2106183132 cites W2062412316 @default.
• W2106183132 cites W2063731065 @default.
• W2106183132 cites W2077216155 @default.
• W2106183132 cites W2079306940 @default.
• W2106183132 cites W2083959103 @default.
• W2106183132 cites W2084674840 @default.
• W2106183132 cites W2089168500 @default.
• W2106183132 cites W2089202931 @default.
• W2106183132 cites W2092292418 @default.
• W2106183132 cites W2103546861 @default.
• W2106183132 cites W2106882534 @default.
• W2106183132 cites W2108222684 @default.
• W2106183132 cites W2125350378 @default.
• W2106183132 cites W2133300351 @default.
• W2106183132 cites W2140149838 @default.
• W2106183132 cites W2140904612 @default.
• W2106183132 cites W2146058063 @default.
• W2106183132 cites W2153819784 @default.
• W2106183132 cites W2156871594 @default.
• W2106183132 cites W2158266834 @default.
• W2106183132 cites W2158714788 @default.
• W2106183132 cites W2161444534 @default.
• W2106183132 cites W2170996473 @default.
• W2106183132 cites W2192034700 @default.
• W2106183132 cites W2976019987 @default.
• W2106183132 cites W4233481370 @default.
• W2106183132 cites W7030253 @default.
• W2106183132 doi "https://doi.org/10.1007/s00239-009-9263-0" @default.
• W2106183132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4136416" @default.
• W2106183132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19639238" @default.
• W2106183132 hasPublicationYear "2009" @default.
• W2106183132 type Work @default.
• W2106183132 sameAs 2106183132 @default.
• W2106183132 citedByCount "88" @default.
• W2106183132 countsByYear W21061831322012 @default.
• W2106183132 countsByYear W21061831322013 @default.
• W2106183132 countsByYear W21061831322014 @default.
• W2106183132 countsByYear W21061831322015 @default.
• W2106183132 countsByYear W21061831322016 @default.
• W2106183132 countsByYear W21061831322017 @default.
• W2106183132 countsByYear W21061831322018 @default.
• W2106183132 countsByYear W21061831322019 @default.
• W2106183132 countsByYear W21061831322020 @default.
• W2106183132 countsByYear W21061831322021 @default.
• W2106183132 countsByYear W21061831322022 @default.
• W2106183132 countsByYear W21061831322023 @default.
• W2106183132 crossrefType "journal-article" @default.
• W2106183132 hasAuthorship W2106183132A5020392576 @default.
• W2106183132 hasAuthorship W2106183132A5038792936 @default.
• W2106183132 hasAuthorship W2106183132A5077361345 @default.
• W2106183132 hasBestOaLocation W21061831322 @default.
• W2106183132 hasConcept C104317684 @default.
• W2106183132 hasConcept C141231307 @default.
• W2106183132 hasConcept C165525559 @default.
• W2106183132 hasConcept C193252679 @default.
• W2106183132 hasConcept C54355233 @default.
• W2106183132 hasConcept C7602840 @default.
• W2106183132 hasConcept C78458016 @default.
• W2106183132 hasConcept C86803240 @default.
• W2106183132 hasConcept C90132467 @default.
• W2106183132 hasConceptScore W2106183132C104317684 @default.
• W2106183132 hasConceptScore W2106183132C141231307 @default.
• W2106183132 hasConceptScore W2106183132C165525559 @default.
• W2106183132 hasConceptScore W2106183132C193252679 @default.
• W2106183132 hasConceptScore W2106183132C54355233 @default.
• W2106183132 hasConceptScore W2106183132C7602840 @default.

• next