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- W2106184421 abstract "Our laboratory provided the first proof-of-concept that double-stranded short interfering RNA (ds-siRNA) can act as potent and specific antiviral agents. Designed against specific mRNAs of nonsegmented negative-stranded RNA (NNR) viruses, siRNAs abrogated expression of the corresponding viral proteins, and generated the predicted viral phenotypes. Knockdown was demonstrated across different genera: respiratory syncytial virus (RSV), a pneumovirus; vesicular stomatitis virus (VSV), a rhabdovirus; and human parainfluenza virus (HPIV), a paramyxovirus. The targeted genes could have a wide range of functions, thus documenting the versatility of the technique. Interestingly, antisense single-stranded siRNA (ss-siRNA) was also effective, albeit at a higher concentration. NNR viral genomic and antigenomic RNA, which are encapsidated by nucleocapsid protein and serve as templates for viral RNA-dependent RNA polymerase, were resistant to siRNA. Together, siRNAs offer complementary advantages over traditional mutational analyses that are difficult to perform in NNR viruses, and are also an important new tool to dissect host–virus interactive pathways." @default.
- W2106184421 created "2016-06-24" @default.
- W2106184421 creator A5007213279 @default.
- W2106184421 date "2004-06-01" @default.
- W2106184421 modified "2023-10-16" @default.
- W2106184421 title "Control of nonsegmented negative-strand RNA virus replication by siRNA" @default.
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- W2106184421 cites W1537278671 @default.
- W2106184421 cites W1611419331 @default.
- W2106184421 cites W1919761071 @default.
- W2106184421 cites W1921244251 @default.
- W2106184421 cites W1933750471 @default.
- W2106184421 cites W1967110636 @default.
- W2106184421 cites W1974333324 @default.
- W2106184421 cites W1974838108 @default.
- W2106184421 cites W1974861468 @default.
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- W2106184421 doi "https://doi.org/10.1016/j.virusres.2004.01.012" @default.
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