FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106188043> ?p ?o ?g. }

• W2106188043 endingPage "935" @default.
• W2106188043 startingPage "925" @default.
• W2106188043 abstract "T cell factor (TCF) family of transcription factors and beta-catenin critically regulate T cell development as demonstrated by the deletion of the tcf gene, which results in a block early in development that becomes complete in mice bearing tcf/lef double deletion. However, the role of beta-catenin, a major TCF cofactor, remains controversial. To directly address this, we have generated transgenic mice expressing Inhibitor of beta-catenin and TCF (ICAT), a naturally occurring inhibitor that specifically disrupts TCF and beta-catenin interactions. In this report, we demonstrate that disrupting the interaction of beta-catenin with TCF renders adult thymocytes and activated T cells highly susceptible to apoptosis. In contrast to previously reported observations during fetal thymocyte development, these data show that in adult mice, survival and not differentiation of thymocytes, depends on transcription by TCF and beta-catenin. Indeed, we demonstrate that expression of ICAT impedes thymocyte survival by reducing the expression of Bcl(xL) in thymocytes below a critical threshold. Survival of activated mature T cells was also impaired due to diminished expression of activation-induced Bcl(xL). Accordingly, expression of transgenic Bcl-2 rescued activated ICAT-Tg CD4 T cells from apoptosis. Thus, disruption of TCF-beta-catenin interactions specifically impairs the survival of thymocytes and activated T cells." @default.
• W2106188043 created "2016-06-24" @default.
• W2106188043 creator A5000208362 @default.
• W2106188043 creator A5051546133 @default.
• W2106188043 creator A5078317870 @default.
• W2106188043 creator A5086282793 @default.
• W2106188043 date "2008-04-25" @default.
• W2106188043 modified "2023-09-28" @default.
• W2106188043 title "ICAT expression disrupts -catenin-TCF interactions and impairs survival of thymocytes and activated mature T cells" @default.
• W2106188043 cites W1484859051 @default.
• W2106188043 cites W1488633968 @default.
• W2106188043 cites W1507615319 @default.
• W2106188043 cites W1541020923 @default.
• W2106188043 cites W1817917437 @default.
• W2106188043 cites W1853668160 @default.
• W2106188043 cites W1980026279 @default.
• W2106188043 cites W1999582446 @default.
• W2106188043 cites W2003930763 @default.
• W2106188043 cites W2004393209 @default.
• W2106188043 cites W2009783794 @default.
• W2106188043 cites W2012351887 @default.
• W2106188043 cites W2014033847 @default.
• W2106188043 cites W2021222640 @default.
• W2106188043 cites W2034141930 @default.
• W2106188043 cites W2036223112 @default.
• W2106188043 cites W2038982920 @default.
• W2106188043 cites W2039534663 @default.
• W2106188043 cites W2043880243 @default.
• W2106188043 cites W2060400485 @default.
• W2106188043 cites W2062019225 @default.
• W2106188043 cites W2079216888 @default.
• W2106188043 cites W2086267296 @default.
• W2106188043 cites W2091783976 @default.
• W2106188043 cites W2094633951 @default.
• W2106188043 cites W2104989755 @default.
• W2106188043 cites W2114592618 @default.
• W2106188043 cites W2114977173 @default.
• W2106188043 cites W2118988718 @default.
• W2106188043 cites W2129713447 @default.
• W2106188043 cites W2141272764 @default.
• W2106188043 cites W2142463988 @default.
• W2106188043 cites W2145167375 @default.
• W2106188043 cites W2145323427 @default.
• W2106188043 doi "https://doi.org/10.1093/intimm/dxn051" @default.
• W2106188043 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2556852" @default.
• W2106188043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18511409" @default.
• W2106188043 hasPublicationYear "2008" @default.
• W2106188043 type Work @default.
• W2106188043 sameAs 2106188043 @default.
• W2106188043 citedByCount "29" @default.
• W2106188043 countsByYear W21061880432012 @default.
• W2106188043 countsByYear W21061880432013 @default.
• W2106188043 countsByYear W21061880432015 @default.
• W2106188043 countsByYear W21061880432016 @default.
• W2106188043 countsByYear W21061880432017 @default.
• W2106188043 countsByYear W21061880432018 @default.
• W2106188043 countsByYear W21061880432019 @default.
• W2106188043 countsByYear W21061880432020 @default.
• W2106188043 countsByYear W21061880432022 @default.
• W2106188043 crossrefType "journal-article" @default.
• W2106188043 hasAuthorship W2106188043A5000208362 @default.
• W2106188043 hasAuthorship W2106188043A5051546133 @default.
• W2106188043 hasAuthorship W2106188043A5078317870 @default.
• W2106188043 hasAuthorship W2106188043A5086282793 @default.
• W2106188043 hasBestOaLocation W21061880431 @default.
• W2106188043 hasConcept C102230213 @default.
• W2106188043 hasConcept C104317684 @default.
• W2106188043 hasConcept C153911025 @default.
• W2106188043 hasConcept C190283241 @default.
• W2106188043 hasConcept C199360897 @default.
• W2106188043 hasConcept C203014093 @default.
• W2106188043 hasConcept C2776090121 @default.
• W2106188043 hasConcept C2776174256 @default.
• W2106188043 hasConcept C2778954852 @default.
• W2106188043 hasConcept C41008148 @default.
• W2106188043 hasConcept C502942594 @default.
• W2106188043 hasConcept C54355233 @default.
• W2106188043 hasConcept C86339819 @default.
• W2106188043 hasConcept C86803240 @default.
• W2106188043 hasConcept C8891405 @default.
• W2106188043 hasConcept C95444343 @default.
• W2106188043 hasConceptScore W2106188043C102230213 @default.
• W2106188043 hasConceptScore W2106188043C104317684 @default.
• W2106188043 hasConceptScore W2106188043C153911025 @default.
• W2106188043 hasConceptScore W2106188043C190283241 @default.
• W2106188043 hasConceptScore W2106188043C199360897 @default.
• W2106188043 hasConceptScore W2106188043C203014093 @default.
• W2106188043 hasConceptScore W2106188043C2776090121 @default.
• W2106188043 hasConceptScore W2106188043C2776174256 @default.
• W2106188043 hasConceptScore W2106188043C2778954852 @default.
• W2106188043 hasConceptScore W2106188043C41008148 @default.
• W2106188043 hasConceptScore W2106188043C502942594 @default.
• W2106188043 hasConceptScore W2106188043C54355233 @default.
• W2106188043 hasConceptScore W2106188043C86339819 @default.
• W2106188043 hasConceptScore W2106188043C86803240 @default.
• W2106188043 hasConceptScore W2106188043C8891405 @default.
• W2106188043 hasConceptScore W2106188043C95444343 @default.
• W2106188043 hasIssue "7" @default.

• next