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• W2106188260 abstract "The minimum sequence requirements for antigen receptor V-(D)-J joining were studied by constructing recombination-substrates containing synthetic recombination signals and introducing them into a recombination-competent pre-B cell line. Two sets of heptamer (CACTGTG) and nonamer (GGTTTTTGT) sequences were shown to be sufficient to cause the V-(D)-J joining, if the 12- and 23-base pair spacer rule is satisfied. A point mutation in the heptamer sequence, or a change in the combination of the two spacer lengths, drastically reduced the recombination." @default.
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• W2106188260 date "1987-11-20" @default.
• W2106188260 modified "2023-10-04" @default.
• W2106188260 title "Two Pairs of Recombination Signals Are Sufficient to Cause Immunoglobulin V-(D)-J Joining" @default.
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• W2106188260 doi "https://doi.org/10.1126/science.3120312" @default.
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