FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106196733> ?p ?o ?g. }

• W2106196733 endingPage "1026" @default.
• W2106196733 startingPage "1018" @default.
• W2106196733 abstract "Studies have reported that the integrated analysis of microRNA (miRNA)-messenger RNA (mRNA) expression is valuable in exploring gene regulation systemically.The objectives of this study were to identify miRNAs and genes involved in atrial fibrillation and to explore the mechanisms underlying atrial fibrosis.We used microarrays to compare the differences in both miRNA and mRNA expression profiles in the left atrial appendage of patients with nonvalvular paroxysmal atrial fibrillation and healthy controls. Furthermore, the quantitative real-time polymerase chain reaction was used to confirm the reliability of the microarray data, prediction of the adopted databases, and Ingenuity Pathway Analysis of miRNA-mRNA expression in order to identify the miRNA target genes, examine the functions and pathways in which the target genes are involved, and construct an miRNA-target gene regulatory network. We further investigated the roles of miRNA-146b-5p in the mechanisms of atrial fibrosis.We identified 10 differentially expressed miRNAs and 624 differentially expressed mRNAs, among which only 1 miRNA-target gene pair miR-146b-5p and tissue inhibitor of metalloproteinase 4 (TIMP-4) were constructed. The validated results revealed that miR-146b-5p, matrix metallopeptidase 9, and collagen content were upregulated whereas TIMP-4 was downregulated in patients with atrial fibrillation. After the transfection of miR-146b-5p into cardiac fibroblasts, TIMP-4 expression was markedly reduced and collagen content was increased. Moreover, luciferase results confirmed that TIMP-4 was a target of miR-146b-5p.The identified miRNA and mRNA may represent a potentially novel molecular regulatory network, which may provide a better understanding of the molecular basis of remodeling in atrial fibrillation. miR-146b-5p probably acts as an intracellular mediator in the maladaptive remodeling in atrial fibrosis in atrial fibrillation." @default.
• W2106196733 created "2016-06-24" @default.
• W2106196733 creator A5002717804 @default.
• W2106196733 creator A5029475800 @default.
• W2106196733 creator A5040053377 @default.
• W2106196733 creator A5042572513 @default.
• W2106196733 creator A5046363445 @default.
• W2106196733 creator A5046996365 @default.
• W2106196733 creator A5054785361 @default.
• W2106196733 creator A5061287436 @default.
• W2106196733 creator A5074806890 @default.
• W2106196733 creator A5077781746 @default.
• W2106196733 creator A5090615596 @default.
• W2106196733 date "2015-05-01" @default.
• W2106196733 modified "2023-10-16" @default.
• W2106196733 title "Integrated analysis of microRNA and mRNA expression profiles in the left atrium of patients with nonvalvular paroxysmal atrial fibrillation: Role of miR-146b-5p in atrial fibrosis" @default.
• W2106196733 cites W100631648 @default.
• W2106196733 cites W1968394538 @default.
• W2106196733 cites W1977385197 @default.
• W2106196733 cites W1978640640 @default.
• W2106196733 cites W1981533568 @default.
• W2106196733 cites W1990435491 @default.
• W2106196733 cites W1992173759 @default.
• W2106196733 cites W1998272259 @default.
• W2106196733 cites W20074729 @default.
• W2106196733 cites W2011290576 @default.
• W2106196733 cites W2014899966 @default.
• W2106196733 cites W2036584161 @default.
• W2106196733 cites W2036914740 @default.
• W2106196733 cites W2047795954 @default.
• W2106196733 cites W2057918262 @default.
• W2106196733 cites W2059376978 @default.
• W2106196733 cites W2059901199 @default.
• W2106196733 cites W2102656714 @default.
• W2106196733 cites W2132250523 @default.
• W2106196733 cites W2133435868 @default.
• W2106196733 cites W2135910918 @default.
• W2106196733 cites W2138664009 @default.
• W2106196733 cites W2143272602 @default.
• W2106196733 cites W2146159574 @default.
• W2106196733 cites W2157698700 @default.
• W2106196733 cites W2165601673 @default.
• W2106196733 cites W2171404226 @default.
• W2106196733 cites W2171559273 @default.
• W2106196733 cites W4211201645 @default.
• W2106196733 doi "https://doi.org/10.1016/j.hrthm.2015.01.026" @default.
• W2106196733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25617731" @default.
• W2106196733 hasPublicationYear "2015" @default.
• W2106196733 type Work @default.
• W2106196733 sameAs 2106196733 @default.
• W2106196733 citedByCount "47" @default.
• W2106196733 countsByYear W21061967332015 @default.
• W2106196733 countsByYear W21061967332016 @default.
• W2106196733 countsByYear W21061967332017 @default.
• W2106196733 countsByYear W21061967332018 @default.
• W2106196733 countsByYear W21061967332019 @default.
• W2106196733 countsByYear W21061967332020 @default.
• W2106196733 countsByYear W21061967332021 @default.
• W2106196733 countsByYear W21061967332022 @default.
• W2106196733 countsByYear W21061967332023 @default.
• W2106196733 crossrefType "journal-article" @default.
• W2106196733 hasAuthorship W2106196733A5002717804 @default.
• W2106196733 hasAuthorship W2106196733A5029475800 @default.
• W2106196733 hasAuthorship W2106196733A5040053377 @default.
• W2106196733 hasAuthorship W2106196733A5042572513 @default.
• W2106196733 hasAuthorship W2106196733A5046363445 @default.
• W2106196733 hasAuthorship W2106196733A5046996365 @default.
• W2106196733 hasAuthorship W2106196733A5054785361 @default.
• W2106196733 hasAuthorship W2106196733A5061287436 @default.
• W2106196733 hasAuthorship W2106196733A5074806890 @default.
• W2106196733 hasAuthorship W2106196733A5077781746 @default.
• W2106196733 hasAuthorship W2106196733A5090615596 @default.
• W2106196733 hasConcept C104317684 @default.
• W2106196733 hasConcept C105580179 @default.
• W2106196733 hasConcept C126322002 @default.
• W2106196733 hasConcept C145059251 @default.
• W2106196733 hasConcept C150194340 @default.
• W2106196733 hasConcept C165864922 @default.
• W2106196733 hasConcept C18431079 @default.
• W2106196733 hasConcept C186836561 @default.
• W2106196733 hasConcept C2779161974 @default.
• W2106196733 hasConcept C2780559512 @default.
• W2106196733 hasConcept C54355233 @default.
• W2106196733 hasConcept C60644358 @default.
• W2106196733 hasConcept C71924100 @default.
• W2106196733 hasConcept C8415881 @default.
• W2106196733 hasConcept C86803240 @default.
• W2106196733 hasConcept C95371953 @default.
• W2106196733 hasConceptScore W2106196733C104317684 @default.
• W2106196733 hasConceptScore W2106196733C105580179 @default.
• W2106196733 hasConceptScore W2106196733C126322002 @default.
• W2106196733 hasConceptScore W2106196733C145059251 @default.
• W2106196733 hasConceptScore W2106196733C150194340 @default.
• W2106196733 hasConceptScore W2106196733C165864922 @default.
• W2106196733 hasConceptScore W2106196733C18431079 @default.
• W2106196733 hasConceptScore W2106196733C186836561 @default.
• W2106196733 hasConceptScore W2106196733C2779161974 @default.
• W2106196733 hasConceptScore W2106196733C2780559512 @default.

• next