Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106202324> ?p ?o ?g. }
- W2106202324 endingPage "667" @default.
- W2106202324 startingPage "667" @default.
- W2106202324 abstract "The light response in Neurospora is mediated by the photoreceptor and circadian transcription factor White Collar Complex (WCC). The expression rate of the WCC target genes adapts in daylight and remains refractory to moonlight, despite the extraordinary light sensitivity of the WCC. To explain this photoadaptation, feedback inhibition by the WCC interaction partner VIVID (VVD) has been invoked. Here we show through data-driven mathematical modeling that VVD allows Neurospora to detect relative changes in light intensity. To achieve this behavior, VVD acts as an inhibitor of WCC-driven gene expression and, at the same time, as a positive regulator that maintains the responsiveness of the photosystem. Our data indicate that this paradoxical function is realized by a futile cycle that involves the light-induced sequestration of active WCC by VVD and the replenishment of the activatable WCC pool through the decay of the photoactivated state. Our quantitative study uncovers a novel network motif for achieving sensory adaptation and defines a core input module of the circadian clock in Neurospora." @default.
- W2106202324 created "2016-06-24" @default.
- W2106202324 creator A5018609855 @default.
- W2106202324 creator A5022095447 @default.
- W2106202324 creator A5023235079 @default.
- W2106202324 creator A5032088825 @default.
- W2106202324 date "2013-01-01" @default.
- W2106202324 modified "2023-10-14" @default.
- W2106202324 title "The <i>Neurospora</i> photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation" @default.
- W2106202324 cites W1509709236 @default.
- W2106202324 cites W1741525514 @default.
- W2106202324 cites W1842997203 @default.
- W2106202324 cites W1877233814 @default.
- W2106202324 cites W1967506013 @default.
- W2106202324 cites W1970463798 @default.
- W2106202324 cites W1976305103 @default.
- W2106202324 cites W1976971664 @default.
- W2106202324 cites W1979903188 @default.
- W2106202324 cites W1980988105 @default.
- W2106202324 cites W1981166024 @default.
- W2106202324 cites W1988840491 @default.
- W2106202324 cites W1998820908 @default.
- W2106202324 cites W2000646494 @default.
- W2106202324 cites W2000660632 @default.
- W2106202324 cites W2012001954 @default.
- W2106202324 cites W2015898770 @default.
- W2106202324 cites W2019311422 @default.
- W2106202324 cites W2022127539 @default.
- W2106202324 cites W2025224575 @default.
- W2106202324 cites W2033758706 @default.
- W2106202324 cites W2041609788 @default.
- W2106202324 cites W2045317069 @default.
- W2106202324 cites W2060424984 @default.
- W2106202324 cites W2061311715 @default.
- W2106202324 cites W2063220079 @default.
- W2106202324 cites W2075166928 @default.
- W2106202324 cites W2078068028 @default.
- W2106202324 cites W2091520981 @default.
- W2106202324 cites W2095799529 @default.
- W2106202324 cites W2101682056 @default.
- W2106202324 cites W2107242170 @default.
- W2106202324 cites W2110657196 @default.
- W2106202324 cites W2113405823 @default.
- W2106202324 cites W2114417962 @default.
- W2106202324 cites W2115688366 @default.
- W2106202324 cites W2118008483 @default.
- W2106202324 cites W2119649830 @default.
- W2106202324 cites W2120732024 @default.
- W2106202324 cites W2123973944 @default.
- W2106202324 cites W2130618526 @default.
- W2106202324 cites W2133254839 @default.
- W2106202324 cites W2133274717 @default.
- W2106202324 cites W2133403209 @default.
- W2106202324 cites W2138190671 @default.
- W2106202324 cites W2147022672 @default.
- W2106202324 cites W2148818011 @default.
- W2106202324 cites W2151024037 @default.
- W2106202324 cites W2163872057 @default.
- W2106202324 cites W2183578256 @default.
- W2106202324 cites W4247702682 @default.
- W2106202324 doi "https://doi.org/10.1038/msb.2013.24" @default.
- W2106202324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4039372" @default.
- W2106202324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23712010" @default.
- W2106202324 hasPublicationYear "2013" @default.
- W2106202324 type Work @default.
- W2106202324 sameAs 2106202324 @default.
- W2106202324 citedByCount "30" @default.
- W2106202324 countsByYear W21062023242013 @default.
- W2106202324 countsByYear W21062023242014 @default.
- W2106202324 countsByYear W21062023242015 @default.
- W2106202324 countsByYear W21062023242016 @default.
- W2106202324 countsByYear W21062023242017 @default.
- W2106202324 countsByYear W21062023242018 @default.
- W2106202324 countsByYear W21062023242020 @default.
- W2106202324 countsByYear W21062023242021 @default.
- W2106202324 countsByYear W21062023242022 @default.
- W2106202324 countsByYear W21062023242023 @default.
- W2106202324 crossrefType "journal-article" @default.
- W2106202324 hasAuthorship W2106202324A5018609855 @default.
- W2106202324 hasAuthorship W2106202324A5022095447 @default.
- W2106202324 hasAuthorship W2106202324A5023235079 @default.
- W2106202324 hasAuthorship W2106202324A5032088825 @default.
- W2106202324 hasBestOaLocation W21062023242 @default.
- W2106202324 hasConcept C104317684 @default.
- W2106202324 hasConcept C121446783 @default.
- W2106202324 hasConcept C139807058 @default.
- W2106202324 hasConcept C143065580 @default.
- W2106202324 hasConcept C169760540 @default.
- W2106202324 hasConcept C2776739539 @default.
- W2106202324 hasConcept C2776769606 @default.
- W2106202324 hasConcept C2909303214 @default.
- W2106202324 hasConcept C2986477067 @default.
- W2106202324 hasConcept C38606739 @default.
- W2106202324 hasConcept C54355233 @default.
- W2106202324 hasConcept C59822182 @default.
- W2106202324 hasConcept C6929976 @default.
- W2106202324 hasConcept C78458016 @default.
- W2106202324 hasConcept C86339819 @default.