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• W2106204554 endingPage "1831" @default.
• W2106204554 startingPage "1824" @default.
• W2106204554 abstract "Enterotoxigenic Escherichia coli (ETEC) is responsible for 280 million to 400 million episodes of diarrhea and about 380,000 deaths annually. Epidemiological data suggest that ETEC strains which secrete heat-stable toxin (ST), alone or in combination with heat-labile toxin (LT), induce the most severe disease among children in developing countries. This makes ST an attractive target for inclusion in an ETEC vaccine. ST is released upon colonization of the small intestine and activates the guanylate cyclase C receptor, causing profuse diarrhea. To generate a successful toxoid, ST must be made immunogenic and nontoxic. Due to its small size, ST is nonimmunogenic in its natural form but becomes immunogenic when coupled to an appropriate large-molecular-weight carrier. This has been successfully achieved with several carriers, using either chemical conjugation or recombinant fusion techniques. Coupling of ST to a carrier may reduce toxicity, but further reduction by mutagenesis is desired to obtain a safe vaccine. More than 30 ST mutants with effects on toxicity have been reported. Some of these mutants, however, have lost the ability to elicit neutralizing immune responses to the native toxin. Due to the small size of ST, separating toxicity from antigenicity is a particular challenge that must be met. Another obstacle to vaccine development is possible cross-reactivity between anti-ST antibodies and the endogenous ligands guanylin and uroguanylin, caused by structural similarity to ST. Here we review the molecular and biological properties of ST and discuss strategies for developing an ETEC vaccine that incorporates immunogenic and nontoxic derivatives of the ST toxin." @default.
• W2106204554 created "2016-06-24" @default.
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• W2106204554 creator A5045149586 @default.
• W2106204554 creator A5058793391 @default.
• W2106204554 creator A5083946071 @default.
• W2106204554 date "2010-05-01" @default.
• W2106204554 modified "2023-10-05" @default.
• W2106204554 title "Heat-Stable Enterotoxin of Enterotoxigenic <i>Escherichia coli</i> as a Vaccine Target" @default.
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• W2106204554 cites W1543394229 @default.
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• W2106204554 cites W1566211925 @default.
• W2106204554 cites W1579986667 @default.
• W2106204554 cites W1685063743 @default.
• W2106204554 cites W1769141315 @default.
• W2106204554 cites W1822143552 @default.
• W2106204554 cites W1866048318 @default.
• W2106204554 cites W1868899445 @default.
• W2106204554 cites W1886748892 @default.
• W2106204554 cites W1903905786 @default.
• W2106204554 cites W1942915134 @default.
• W2106204554 cites W1957896835 @default.
• W2106204554 cites W1962258665 @default.
• W2106204554 cites W1976938451 @default.
• W2106204554 cites W1983582848 @default.
• W2106204554 cites W1989232298 @default.
• W2106204554 cites W1996795202 @default.
• W2106204554 cites W1999838346 @default.
• W2106204554 cites W2002523543 @default.
• W2106204554 cites W2007555588 @default.
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• W2106204554 cites W2024172270 @default.
• W2106204554 cites W2026039034 @default.
• W2106204554 cites W2026076089 @default.
• W2106204554 cites W2027903939 @default.
• W2106204554 cites W2032645401 @default.
• W2106204554 cites W2032939600 @default.
• W2106204554 cites W2040556194 @default.
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• W2106204554 cites W2081190521 @default.
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• W2106204554 cites W2097985952 @default.
• W2106204554 cites W2100779666 @default.
• W2106204554 cites W2101263074 @default.
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• W2106204554 cites W2147968928 @default.
• W2106204554 cites W2148455913 @default.
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• W2106204554 cites W2154534755 @default.
• W2106204554 cites W2156399146 @default.
• W2106204554 cites W2157739202 @default.
• W2106204554 cites W2159613623 @default.
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• W2106204554 cites W2438492624 @default.
• W2106204554 cites W29281222 @default.
• W2106204554 cites W4249446922 @default.
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• W2106204554 doi "https://doi.org/10.1128/iai.01397-09" @default.
• W2106204554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2863518" @default.
• W2106204554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20231404" @default.
• W2106204554 hasPublicationYear "2010" @default.
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