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• W2106208246 endingPage "345" @default.
• W2106208246 startingPage "327" @default.
• W2106208246 abstract "During excitation, muscle cells gain Na+ and lose K+, leading to a rise in extracellular K+ ([K+]o), depolarization, and loss of excitability. Recent studies support the idea that these events are important causes of muscle fatigue and that full use of the Na+,K+-ATPase (also known as the Na+,K+ pump) is often essential for adequate clearance of extracellular K+. As a result of their electrogenic action, Na+,K+ pumps also help reverse depolarization arising during excitation, hyperkalemia, and anoxia, or from cell damage resulting from exercise, rhabdomyolysis, or muscle diseases. The ability to evaluate Na+,K+-pump function and the capacity of the Na+,K+ pumps to fill these needs require quantification of the total content of Na+,K+ pumps in skeletal muscle. Inhibition of Na+,K+-pump activity, or a decrease in their content, reduces muscle contractility. Conversely, stimulation of the Na+,K+-pump transport rate or increasing the content of Na+,K+ pumps enhances muscle excitability and contractility. Measurements of [3H]ouabain binding to skeletal muscle in vivo or in vitro have enabled the reproducible quantification of the total content of Na+,K+ pumps in molar units in various animal species, and in both healthy people and individuals with various diseases. In contrast, measurements of 3-O-methylfluorescein phosphatase activity associated with the Na+,K+-ATPase may show inconsistent results. Measurements of Na+ and K+ fluxes in intact isolated muscles show that, after Na+ loading or intense excitation, all the Na+,K+ pumps are functional, allowing calculation of the maximum Na+,K+-pumping capacity, expressed in molar units/g muscle/min. The activity and content of Na+,K+ pumps are regulated by exercise, inactivity, K+ deficiency, fasting, age, and several hormones and pharmaceuticals. Studies on the α-subunit isoforms of the Na+,K+-ATPase have detected a relative increase in their number in response to exercise and the glucocorticoid dexamethasone but have not involved their quantification in molar units. Determination of ATPase activity in homogenates and plasma membranes obtained from muscle has shown ouabain-suppressible stimulatory effects of Na+ and K+." @default.
• W2106208246 created "2016-06-24" @default.
• W2106208246 creator A5060718090 @default.
• W2106208246 date "2013-09-30" @default.
• W2106208246 modified "2023-10-12" @default.
• W2106208246 title "Quantification of Na+,K+ pumps and their transport rate in skeletal muscle: Functional significance" @default.
• W2106208246 cites W1523557554 @default.
• W2106208246 cites W1527454558 @default.
• W2106208246 cites W1549212895 @default.
• W2106208246 cites W1574594312 @default.
• W2106208246 cites W1606565754 @default.
• W2106208246 cites W162467690 @default.
• W2106208246 cites W1752536946 @default.
• W2106208246 cites W1758970340 @default.
• W2106208246 cites W1829737793 @default.
• W2106208246 cites W1895105262 @default.
• W2106208246 cites W1935697666 @default.
• W2106208246 cites W1965242125 @default.
• W2106208246 cites W1965722852 @default.
• W2106208246 cites W1967504931 @default.
• W2106208246 cites W1969380690 @default.
• W2106208246 cites W1971215263 @default.
• W2106208246 cites W1974657144 @default.
• W2106208246 cites W1976684150 @default.
• W2106208246 cites W1978742218 @default.
• W2106208246 cites W1988252922 @default.
• W2106208246 cites W1993589792 @default.
• W2106208246 cites W1995065384 @default.
• W2106208246 cites W1996202212 @default.
• W2106208246 cites W2000511037 @default.
• W2106208246 cites W2002933714 @default.
• W2106208246 cites W2006033151 @default.
• W2106208246 cites W2009136540 @default.
• W2106208246 cites W2009720226 @default.
• W2106208246 cites W2012213797 @default.
• W2106208246 cites W2012953940 @default.
• W2106208246 cites W2021775223 @default.
• W2106208246 cites W2021944938 @default.
• W2106208246 cites W2022834506 @default.
• W2106208246 cites W2027690360 @default.
• W2106208246 cites W2030674556 @default.
• W2106208246 cites W2031109036 @default.
• W2106208246 cites W2031553442 @default.
• W2106208246 cites W2034960608 @default.
• W2106208246 cites W2038616931 @default.
• W2106208246 cites W2039306153 @default.
• W2106208246 cites W2042874117 @default.
• W2106208246 cites W2044267951 @default.
• W2106208246 cites W2046637515 @default.
• W2106208246 cites W2047279542 @default.
• W2106208246 cites W2053136795 @default.
• W2106208246 cites W2053972698 @default.
• W2106208246 cites W2057914770 @default.
• W2106208246 cites W2061165996 @default.
• W2106208246 cites W2065630380 @default.
• W2106208246 cites W2069166877 @default.
• W2106208246 cites W2072338371 @default.
• W2106208246 cites W2074457873 @default.
• W2106208246 cites W2077124160 @default.
• W2106208246 cites W2078211577 @default.
• W2106208246 cites W2078421703 @default.
• W2106208246 cites W2081853649 @default.
• W2106208246 cites W2084868341 @default.
• W2106208246 cites W2085476151 @default.
• W2106208246 cites W2088914168 @default.
• W2106208246 cites W2089920272 @default.
• W2106208246 cites W2093484764 @default.
• W2106208246 cites W2093545257 @default.
• W2106208246 cites W2096926851 @default.
• W2106208246 cites W2099605274 @default.
• W2106208246 cites W2107177763 @default.
• W2106208246 cites W2109193104 @default.
• W2106208246 cites W2111677946 @default.
• W2106208246 cites W2113156833 @default.
• W2106208246 cites W2119140658 @default.
• W2106208246 cites W2119164920 @default.
• W2106208246 cites W2124008559 @default.
• W2106208246 cites W2124900820 @default.
• W2106208246 cites W2128713049 @default.
• W2106208246 cites W2128766971 @default.
• W2106208246 cites W2128804656 @default.
• W2106208246 cites W2130540452 @default.
• W2106208246 cites W2135931556 @default.
• W2106208246 cites W2137020512 @default.
• W2106208246 cites W2139833411 @default.
• W2106208246 cites W2141901588 @default.
• W2106208246 cites W2144193033 @default.
• W2106208246 cites W2145673220 @default.
• W2106208246 cites W2150112028 @default.
• W2106208246 cites W2150561094 @default.
• W2106208246 cites W2154567517 @default.
• W2106208246 cites W2156262323 @default.
• W2106208246 cites W2158075045 @default.
• W2106208246 cites W2159548391 @default.
• W2106208246 cites W2160985140 @default.
• W2106208246 cites W2163355891 @default.
• W2106208246 cites W2163931216 @default.
• W2106208246 cites W2165603853 @default.

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