FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106209054> ?p ?o ?g. }

• W2106209054 endingPage "272" @default.
• W2106209054 startingPage "267" @default.
• W2106209054 abstract "The most common side-effect of statins, mainly during dose titration, is liver toxicity, In these cases, sufficient control of low density lipoprotein cholesterol (LDL-C) in patients with heterozygous familial hypercholesterolaemia (HFH) becomes problematical. In patients with intolerance to resins as well, especially in the presence of coronary artery disease (CAD), it is practically impossible to reach the LDL-C treatment goal. This study included seven HFH patients with CAD, who presented with alanine amino transferase levels greater than three times the upper normal limit during dose titration of atorvastatin or simvastatin of from 20 mg/day to 40 mg/day. They could not tolerate concomitant cholestyramine administration, and presented with LDL-C levels significantly higher than the treatment goal (100 mg/dl; 2.6 mmol/l). In these patients, a combination of two statins with different pharmacokinetics (20 mg/day of atorvastatin plus 40mg/day of pravastatin) was administered for a mean period of one year. Efficacy was compared with that of monotherapy with each drug alone and with that of 40 mg of atorvastatin in 13 patients, who could also not tolerate resin co-administration, and that of 40 mg/day of atorvastatin plus 12 g of cholestyramine in 30 patients, with similar pretreatment LDL-C levels. No increase in serum transaminases and no symptom or sign of myopathy was recorded during the administration of the combination of the two statins for a mean period of 12 months. The atorvastatin plus pravastatin regimen was more effective than both monotherapies and equally effective with the 40 mg of atorvastatin and the 40 mg of atorvastatin plus 12 g of cholestyramine regimens in reducing LDL-C (59% vs. 57% and 61%, respectively) and triglyceride levels (31% vs. 32% and 28%, respectively), while it also had a better effect on high density lipoprotein cholesterol (13% vs. 7% and 8%). The data suggest that the atorvastatin-pravastatin combination has a highly beneficial effect on all lipid parameters, without causing hepatotoxicity, in HFH patients with CAD who are sensitive to higher doses of statins in monotherapy. These results require confirmation in larger studies." @default.
• W2106209054 created "2016-06-24" @default.
• W2106209054 creator A5018326937 @default.
• W2106209054 creator A5024941127 @default.
• W2106209054 creator A5058561558 @default.
• W2106209054 creator A5075075253 @default.
• W2106209054 date "2001-12-01" @default.
• W2106209054 modified "2023-09-24" @default.
• W2106209054 title "Atorvastatin Plus Pravastatin for the Treatment of Heterozygous Familial Hypercholesterolaemia - A Pilot Study" @default.
• W2106209054 cites W1238554862 @default.
• W2106209054 cites W1505284129 @default.
• W2106209054 cites W1560941842 @default.
• W2106209054 cites W1764668080 @default.
• W2106209054 cites W1964861407 @default.
• W2106209054 cites W1970807871 @default.
• W2106209054 cites W1978890467 @default.
• W2106209054 cites W1989063565 @default.
• W2106209054 cites W1994527422 @default.
• W2106209054 cites W2002487447 @default.
• W2106209054 cites W2026441144 @default.
• W2106209054 cites W2030357298 @default.
• W2106209054 cites W2030431948 @default.
• W2106209054 cites W2045545694 @default.
• W2106209054 cites W2057674977 @default.
• W2106209054 cites W2063842926 @default.
• W2106209054 cites W2066868964 @default.
• W2106209054 cites W2068015621 @default.
• W2106209054 cites W2077861214 @default.
• W2106209054 cites W2078027003 @default.
• W2106209054 cites W2093024779 @default.
• W2106209054 cites W2098295553 @default.
• W2106209054 cites W2102602093 @default.
• W2106209054 cites W2103717161 @default.
• W2106209054 cites W2112728084 @default.
• W2106209054 cites W2114388806 @default.
• W2106209054 cites W2116164479 @default.
• W2106209054 cites W2118310760 @default.
• W2106209054 cites W2119850329 @default.
• W2106209054 cites W2124931981 @default.
• W2106209054 cites W2133466969 @default.
• W2106209054 cites W2138220081 @default.
• W2106209054 cites W2148459936 @default.
• W2106209054 cites W2412763487 @default.
• W2106209054 cites W2414007763 @default.
• W2106209054 cites W37100060 @default.
• W2106209054 cites W78776573 @default.
• W2106209054 doi "https://doi.org/10.1185/030079901753403162" @default.
• W2106209054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11922400" @default.
• W2106209054 hasPublicationYear "2001" @default.
• W2106209054 type Work @default.
• W2106209054 sameAs 2106209054 @default.
• W2106209054 citedByCount "3" @default.
• W2106209054 countsByYear W21062090542019 @default.
• W2106209054 crossrefType "journal-article" @default.
• W2106209054 hasAuthorship W2106209054A5018326937 @default.
• W2106209054 hasAuthorship W2106209054A5024941127 @default.
• W2106209054 hasAuthorship W2106209054A5058561558 @default.
• W2106209054 hasAuthorship W2106209054A5075075253 @default.
• W2106209054 hasConcept C126322002 @default.
• W2106209054 hasConcept C134018914 @default.
• W2106209054 hasConcept C2776839432 @default.
• W2106209054 hasConcept C2777482532 @default.
• W2106209054 hasConcept C2778163477 @default.
• W2106209054 hasConcept C2778697171 @default.
• W2106209054 hasConcept C2779384505 @default.
• W2106209054 hasConcept C2779519902 @default.
• W2106209054 hasConcept C2780499067 @default.
• W2106209054 hasConcept C71924100 @default.
• W2106209054 hasConcept C90924648 @default.
• W2106209054 hasConcept C98274493 @default.
• W2106209054 hasConceptScore W2106209054C126322002 @default.
• W2106209054 hasConceptScore W2106209054C134018914 @default.
• W2106209054 hasConceptScore W2106209054C2776839432 @default.
• W2106209054 hasConceptScore W2106209054C2777482532 @default.
• W2106209054 hasConceptScore W2106209054C2778163477 @default.
• W2106209054 hasConceptScore W2106209054C2778697171 @default.
• W2106209054 hasConceptScore W2106209054C2779384505 @default.
• W2106209054 hasConceptScore W2106209054C2779519902 @default.
• W2106209054 hasConceptScore W2106209054C2780499067 @default.
• W2106209054 hasConceptScore W2106209054C71924100 @default.
• W2106209054 hasConceptScore W2106209054C90924648 @default.
• W2106209054 hasConceptScore W2106209054C98274493 @default.
• W2106209054 hasIssue "4" @default.
• W2106209054 hasLocation W21062090541 @default.
• W2106209054 hasLocation W21062090542 @default.
• W2106209054 hasOpenAccess W2106209054 @default.
• W2106209054 hasPrimaryLocation W21062090541 @default.
• W2106209054 hasRelatedWork W138064960 @default.
• W2106209054 hasRelatedWork W1581747141 @default.
• W2106209054 hasRelatedWork W2038338711 @default.
• W2106209054 hasRelatedWork W2068685076 @default.
• W2106209054 hasRelatedWork W2152065670 @default.
• W2106209054 hasRelatedWork W2308863118 @default.
• W2106209054 hasRelatedWork W2899890584 @default.
• W2106209054 hasRelatedWork W3047501331 @default.
• W2106209054 hasRelatedWork W4243799561 @default.
• W2106209054 hasRelatedWork W4291819813 @default.
• W2106209054 hasVolume "17" @default.

• next