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- W2106244705 abstract "The pleiotropic actions of neuromodulators on pre- and postsynaptic targets make disentangling the mechanisms underlying regulation of synaptic transmission challenging. In the striatum, acetylcholine modulates glutamate release via activation of muscarinic receptors (mAchRs), although the consequences for postsynaptic signaling are unclear. Using two-photon microscopy and glutamate uncaging to examine individual synapses in the rat striatum, we found that glutamatergic afferents have a high degree of multivesicular release (MVR) in the absence of postsynaptic receptor saturation. We found that mAchR activation decreased both the probability of release and the concentration of glutamate in the synaptic cleft. The corresponding decrease in synaptic potency reduced the duration of synaptic potentials and limited temporal summation of afferent inputs. These findings reveal a mechanism by which a combination of basal MVR and low receptor saturation allow the presynaptic actions of a neuromodulator to control the engagement of postsynaptic nonlinearities and regulate synaptic integration." @default.
- W2106244705 created "2016-06-24" @default.
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- W2106244705 date "2009-08-09" @default.
- W2106244705 modified "2023-10-02" @default.
- W2106244705 title "Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration" @default.
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- W2106244705 doi "https://doi.org/10.1038/nn.2368" @default.
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