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- W2106260246 endingPage "1737" @default.
- W2106260246 startingPage "1730" @default.
- W2106260246 abstract "Investigations of fear conditioning in rodents and humans have illuminated the neural mechanisms of fear acquisition and extinction. However, the neural mechanism of memory consolidation of fear conditioning is not well understood. To address this question, we measured brain activity and the changes in functional connectivity following fear acquisition using resting-state functional magnetic resonance imaging. The amygdala–dorsal anterior cingulate cortex (dACC) and hippocampus–insula functional connectivity were enhanced, whereas the amygdala–medial prefrontal cortex (mPFC) functional coupling was decreased during fear memory consolidation. Furthermore, the amygdala–mPFC functional connectivity was negatively correlated with the subjective fear ratings. These findings suggest the amygdala functional connectivity with dACC and mPFC may play an important role in memory consolidation of fear conditioning. The change of amygdala-mPFC functional connectivity could predict the subjective fear. Accordingly, this study provides a new perspective for understanding fear memory consolidation." @default.
- W2106260246 created "2016-06-24" @default.
- W2106260246 creator A5074753582 @default.
- W2106260246 creator A5077760321 @default.
- W2106260246 creator A5084947167 @default.
- W2106260246 creator A5087275646 @default.
- W2106260246 date "2013-12-11" @default.
- W2106260246 modified "2023-09-30" @default.
- W2106260246 title "Memory consolidation of fear conditioning: Bi-stable amygdala connectivity with dorsal anterior cingulate and medial prefrontal cortex" @default.
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- W2106260246 doi "https://doi.org/10.1093/scan/nst170" @default.
- W2106260246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4221215" @default.
- W2106260246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24194579" @default.
- W2106260246 hasPublicationYear "2013" @default.
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