FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106262783> ?p ?o ?g. }

• W2106262783 endingPage "8" @default.
• W2106262783 startingPage "653" @default.
• W2106262783 abstract "The mutational spectrum of mismatch repair (MMR) genes in the Baltic States has been reported to be quite similar to that in Poland; however during a country-wide study considerable differences in the population of Latvia were discovered. This study was undertaken to investigate the clinical and molecular features of HNPCC in Latvia.Family cancer histories were collected, from January 2000 until October 2003, for 702 consecutive hospital based colorectal cancer (CRC) cases. In families suspected of having a history consistent with hereditary non-polyposis colorectal cancer (HNPCC), DNA testing for MLH1, MSH2 and MSH6 genes was performed. Immunohistochemical examination of the normal and the cancer tissue from large bowel tumors was undertaken for MSH2 and MSH6 protein expression in 182 out of 702 (26%) of the cases.Among the 702 CRC patients only 1 (0.14%) fulfilled the Amsterdam criteria. Thirteen (1.9%) cases matched the criteria for suspected HNPCC and 10 (1.4%) cases matched the late onset HNPCC criteria. Altogether in 7 out of 702 (1%) cases MMR gene mutations were detected: 2 in MLH1, 3 in MSH2 and 2 in MSH6 gene. Only one out of the seven mutations was registered in the Human Genome Mutation Database and the ICG (International Collaborational Group)-HNPCC mutation data base. Negative MSH2 and MSH6 protein expression was detected in 4 (2.2%) and 18 out of 182 (9.9%) cases respectively.The role of the classical Amsterdam criteria in diagnosing HNPCC in CRC patients from Latvia is very limited and diagnostic criteria for suspected HNPCC are the most effective. The frequency of constitutional mutations within the MMR genes is 1% of all newly diagnosed CRC cases and the spectrum of mutations is potentially characteristic." @default.
• W2106262783 created "2016-06-24" @default.
• W2106262783 creator A5006490816 @default.
• W2106262783 creator A5018054072 @default.
• W2106262783 creator A5023203292 @default.
• W2106262783 creator A5033989935 @default.
• W2106262783 creator A5035945519 @default.
• W2106262783 creator A5045766478 @default.
• W2106262783 creator A5077152126 @default.
• W2106262783 creator A5081450529 @default.
• W2106262783 creator A5084489441 @default.
• W2106262783 date "2007-03-14" @default.
• W2106262783 modified "2023-10-05" @default.
• W2106262783 title "Nationwide study of clinical and molecular features of hereditary non-polyposis colorectal cancer (HNPCC) in Latvia." @default.
• W2106262783 cites W1494943394 @default.
• W2106262783 cites W1907599506 @default.
• W2106262783 cites W1974807162 @default.
• W2106262783 cites W1992418280 @default.
• W2106262783 cites W2031655504 @default.
• W2106262783 cites W2050721998 @default.
• W2106262783 cites W2062305215 @default.
• W2106262783 cites W2081680846 @default.
• W2106262783 cites W2098754043 @default.
• W2106262783 cites W2112677111 @default.
• W2106262783 cites W2117618517 @default.
• W2106262783 cites W2124719404 @default.
• W2106262783 cites W2124896165 @default.
• W2106262783 cites W2126222796 @default.
• W2106262783 cites W2131666734 @default.
• W2106262783 cites W2144437155 @default.
• W2106262783 cites W2149096696 @default.
• W2106262783 cites W2159429807 @default.
• W2106262783 cites W2163621296 @default.
• W2106262783 cites W2416167561 @default.
• W2106262783 cites W2789798909 @default.
• W2106262783 cites W308408054 @default.
• W2106262783 cites W37935732 @default.
• W2106262783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17348456" @default.
• W2106262783 hasPublicationYear "2007" @default.
• W2106262783 type Work @default.
• W2106262783 sameAs 2106262783 @default.
• W2106262783 citedByCount "3" @default.
• W2106262783 crossrefType "journal-article" @default.
• W2106262783 hasAuthorship W2106262783A5006490816 @default.
• W2106262783 hasAuthorship W2106262783A5018054072 @default.
• W2106262783 hasAuthorship W2106262783A5023203292 @default.
• W2106262783 hasAuthorship W2106262783A5033989935 @default.
• W2106262783 hasAuthorship W2106262783A5035945519 @default.
• W2106262783 hasAuthorship W2106262783A5045766478 @default.
• W2106262783 hasAuthorship W2106262783A5077152126 @default.
• W2106262783 hasAuthorship W2106262783A5081450529 @default.
• W2106262783 hasAuthorship W2106262783A5084489441 @default.
• W2106262783 hasConcept C104317684 @default.
• W2106262783 hasConcept C111425858 @default.
• W2106262783 hasConcept C121608353 @default.
• W2106262783 hasConcept C126322002 @default.
• W2106262783 hasConcept C143998085 @default.
• W2106262783 hasConcept C2776559941 @default.
• W2106262783 hasConcept C2776674815 @default.
• W2106262783 hasConcept C2779115348 @default.
• W2106262783 hasConcept C2908647359 @default.
• W2106262783 hasConcept C2994225774 @default.
• W2106262783 hasConcept C501734568 @default.
• W2106262783 hasConcept C526805850 @default.
• W2106262783 hasConcept C54355233 @default.
• W2106262783 hasConcept C60748783 @default.
• W2106262783 hasConcept C71924100 @default.
• W2106262783 hasConcept C86803240 @default.
• W2106262783 hasConcept C99454951 @default.
• W2106262783 hasConceptScore W2106262783C104317684 @default.
• W2106262783 hasConceptScore W2106262783C111425858 @default.
• W2106262783 hasConceptScore W2106262783C121608353 @default.
• W2106262783 hasConceptScore W2106262783C126322002 @default.
• W2106262783 hasConceptScore W2106262783C143998085 @default.
• W2106262783 hasConceptScore W2106262783C2776559941 @default.
• W2106262783 hasConceptScore W2106262783C2776674815 @default.
• W2106262783 hasConceptScore W2106262783C2779115348 @default.
• W2106262783 hasConceptScore W2106262783C2908647359 @default.
• W2106262783 hasConceptScore W2106262783C2994225774 @default.
• W2106262783 hasConceptScore W2106262783C501734568 @default.
• W2106262783 hasConceptScore W2106262783C526805850 @default.
• W2106262783 hasConceptScore W2106262783C54355233 @default.
• W2106262783 hasConceptScore W2106262783C60748783 @default.
• W2106262783 hasConceptScore W2106262783C71924100 @default.
• W2106262783 hasConceptScore W2106262783C86803240 @default.
• W2106262783 hasConceptScore W2106262783C99454951 @default.
• W2106262783 hasIssue "1B" @default.
• W2106262783 hasLocation W21062627831 @default.
• W2106262783 hasOpenAccess W2106262783 @default.
• W2106262783 hasPrimaryLocation W21062627831 @default.
• W2106262783 hasRelatedWork W1970356798 @default.
• W2106262783 hasRelatedWork W1970565131 @default.
• W2106262783 hasRelatedWork W1973138708 @default.
• W2106262783 hasRelatedWork W1974592005 @default.
• W2106262783 hasRelatedWork W1989209646 @default.
• W2106262783 hasRelatedWork W1993373816 @default.
• W2106262783 hasRelatedWork W2003064500 @default.
• W2106262783 hasRelatedWork W2005315137 @default.

• next