FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106266989> ?p ?o ?g. }

• W2106266989 abstract "Following the recent Ongoing Telmistartan Alone and in Combination With Ramipril Global Endpoint Trial (ONTARGET) finding of adverse renal outcomes, dual renin-angiotensin blockade has fallen out of favour, despite antihypertensive and antiproteinuric efficacy. However, in high-risk severe hypertension, not studied in ONTARGET, whether combination treatment should be withheld or withdrawn is not clear. We examine the renal effects of angiotensin-converting enzyme inhibitor (ACE-I) and angiotensin II receptor blocker (ARB) monotherapy versus combination therapy in patients with type 2 diabetes and varying degrees of hypertension.Subjects attending a hospital diabetes centre were selected as case (combination therapy, n = 120) and control (monotherapy, n = 480). Subjects were matched for age, gender, ethnicity, estimated glomerular filtration rate (eGFR), blood pressure (BP) and study duration. Patients were stratified by BP, hypertension stage 1 (BP < 160/100, n = 506) and stage 2 (≥160/100, n = 94), and by treatment group. Data were analysed for the primary renal outcome of eGFR decline ≥20 ml/min, over a median of 3.7 years.In keeping with the ONTARGET study, for stage 1 hypertension, combination treatment is significantly worse than monotherapy for the primary outcome of eGFR decline ≥20 ml/min (20 vs. 10.7%, p = 0.01). In contrast, for stage 2 hypertension, this endpoint was reached less often for combination versus monotherapy (12.0 vs. 23.2%, p = 0.2). Combination treatment was also not detrimental in patients with proteinuria or eGFR < 60 ml/min and was associated with fewer macrovascular events.Given that hypertension control is paramount and in the spirit of primum non nocere, these data are reassuring should clinicians choose to use ACE-I and ARB combination therapy in the very hypertensive diabetic patient." @default.
• W2106266989 created "2016-06-24" @default.
• W2106266989 creator A5006947382 @default.
• W2106266989 creator A5014852818 @default.
• W2106266989 creator A5049090208 @default.
• W2106266989 creator A5078992370 @default.
• W2106266989 creator A5081864470 @default.
• W2106266989 date "2010-10-26" @default.
• W2106266989 modified "2023-09-25" @default.
• W2106266989 title "Beyond ONTARGET: angiotensin-converting enzyme inhibition and angiotensin II receptor blockade in combination, a lesser evil in some?" @default.
• W2106266989 cites W1604542334 @default.
• W2106266989 cites W1977075739 @default.
• W2106266989 cites W2004298135 @default.
• W2106266989 cites W2010912810 @default.
• W2106266989 cites W2011797220 @default.
• W2106266989 cites W2026021204 @default.
• W2106266989 cites W2030408237 @default.
• W2106266989 cites W2044198626 @default.
• W2106266989 cites W2053330911 @default.
• W2106266989 cites W2066450124 @default.
• W2106266989 cites W2084343172 @default.
• W2106266989 cites W2100409734 @default.
• W2106266989 cites W2105206774 @default.
• W2106266989 cites W2107195787 @default.
• W2106266989 cites W2108702111 @default.
• W2106266989 cites W2114614037 @default.
• W2106266989 cites W2131903071 @default.
• W2106266989 cites W2137177722 @default.
• W2106266989 cites W2138867504 @default.
• W2106266989 cites W2146582345 @default.
• W2106266989 cites W2149673384 @default.
• W2106266989 cites W2152798629 @default.
• W2106266989 cites W2156121263 @default.
• W2106266989 cites W3021479541 @default.
• W2106266989 doi "https://doi.org/10.1111/j.1463-1326.2010.01298.x" @default.
• W2106266989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20977578" @default.
• W2106266989 hasPublicationYear "2010" @default.
• W2106266989 type Work @default.
• W2106266989 sameAs 2106266989 @default.
• W2106266989 citedByCount "9" @default.
• W2106266989 countsByYear W21062669892012 @default.
• W2106266989 countsByYear W21062669892013 @default.
• W2106266989 countsByYear W21062669892015 @default.
• W2106266989 countsByYear W21062669892016 @default.
• W2106266989 crossrefType "journal-article" @default.
• W2106266989 hasAuthorship W2106266989A5006947382 @default.
• W2106266989 hasAuthorship W2106266989A5014852818 @default.
• W2106266989 hasAuthorship W2106266989A5049090208 @default.
• W2106266989 hasAuthorship W2106266989A5078992370 @default.
• W2106266989 hasAuthorship W2106266989A5081864470 @default.
• W2106266989 hasConcept C104849204 @default.
• W2106266989 hasConcept C126322002 @default.
• W2106266989 hasConcept C126894567 @default.
• W2106266989 hasConcept C134018914 @default.
• W2106266989 hasConcept C159641895 @default.
• W2106266989 hasConcept C164705383 @default.
• W2106266989 hasConcept C203092338 @default.
• W2106266989 hasConcept C27016395 @default.
• W2106266989 hasConcept C2776999253 @default.
• W2106266989 hasConcept C2777180221 @default.
• W2106266989 hasConcept C2779561371 @default.
• W2106266989 hasConcept C2779716603 @default.
• W2106266989 hasConcept C2779888176 @default.
• W2106266989 hasConcept C2780091579 @default.
• W2106266989 hasConcept C2908929049 @default.
• W2106266989 hasConcept C535046627 @default.
• W2106266989 hasConcept C555293320 @default.
• W2106266989 hasConcept C71924100 @default.
• W2106266989 hasConcept C84393581 @default.
• W2106266989 hasConceptScore W2106266989C104849204 @default.
• W2106266989 hasConceptScore W2106266989C126322002 @default.
• W2106266989 hasConceptScore W2106266989C126894567 @default.
• W2106266989 hasConceptScore W2106266989C134018914 @default.
• W2106266989 hasConceptScore W2106266989C159641895 @default.
• W2106266989 hasConceptScore W2106266989C164705383 @default.
• W2106266989 hasConceptScore W2106266989C203092338 @default.
• W2106266989 hasConceptScore W2106266989C27016395 @default.
• W2106266989 hasConceptScore W2106266989C2776999253 @default.
• W2106266989 hasConceptScore W2106266989C2777180221 @default.
• W2106266989 hasConceptScore W2106266989C2779561371 @default.
• W2106266989 hasConceptScore W2106266989C2779716603 @default.
• W2106266989 hasConceptScore W2106266989C2779888176 @default.
• W2106266989 hasConceptScore W2106266989C2780091579 @default.
• W2106266989 hasConceptScore W2106266989C2908929049 @default.
• W2106266989 hasConceptScore W2106266989C535046627 @default.
• W2106266989 hasConceptScore W2106266989C555293320 @default.
• W2106266989 hasConceptScore W2106266989C71924100 @default.
• W2106266989 hasConceptScore W2106266989C84393581 @default.
• W2106266989 hasLocation W21062669891 @default.
• W2106266989 hasLocation W21062669892 @default.
• W2106266989 hasOpenAccess W2106266989 @default.
• W2106266989 hasPrimaryLocation W21062669891 @default.
• W2106266989 hasRelatedWork W1592634771 @default.
• W2106266989 hasRelatedWork W1992044918 @default.
• W2106266989 hasRelatedWork W2018008593 @default.
• W2106266989 hasRelatedWork W2020731153 @default.
• W2106266989 hasRelatedWork W2028705700 @default.
• W2106266989 hasRelatedWork W2042889524 @default.
• W2106266989 hasRelatedWork W2100409734 @default.
• W2106266989 hasRelatedWork W2100923541 @default.

• next