FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106278322> ?p ?o ?g. }

• W2106278322 endingPage "582" @default.
• W2106278322 startingPage "572" @default.
• W2106278322 abstract "Patients with metastatic prostate cancer who undergo androgen-ablation therapy invariably relapse and develop incurable castration-resistant disease. Activation of the prosurvival Akt pathway accompanies androgen ablation. We discovered that the androgen receptor induces the expression of the tumor suppressor inositol polyphosphate 4-phosphatase type II (INPP4B) but not PTEN in prostate cancer cells. Optimal induction of INPP4B by an androgen receptor required the expression of the transcriptional coactivator NCoR. INPP4B dephosphorylates phosphatidylinositol-3, 4-bisphosphate, which leads to reduced phosphorylation and activity of Akt. In support of a key role for INPP4B in Akt control, INPP4B depletion activated Akt and increased cellular proliferation. The clinical significance of INPP4B in androgen-dependent prostate cancers was determined in normal or primary tumor prostate tissues derived from radical prostatectomy specimens. In primary tumors, the expression of both INPP4B and PTEN was substantially reduced compared with normal tissue. Further, the decreased expression of INPP4B reduced the time to biochemical recurrence. Thus, androgen ablation can activate the Akt pathway via INPP4B downregulation, thereby mitigating the antitumor effects of androgen ablation. Our findings reinforce the concept that patients undergoing androgen ablation may benefit from Akt-targeting therapies." @default.
• W2106278322 created "2016-06-24" @default.
• W2106278322 creator A5017754323 @default.
• W2106278322 creator A5035997680 @default.
• W2106278322 creator A5036667861 @default.
• W2106278322 creator A5038117448 @default.
• W2106278322 creator A5044090270 @default.
• W2106278322 creator A5061725261 @default.
• W2106278322 creator A5066263660 @default.
• W2106278322 creator A5087750113 @default.
• W2106278322 creator A5088250480 @default.
• W2106278322 date "2011-01-13" @default.
• W2106278322 modified "2023-09-26" @default.
• W2106278322 title "Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer" @default.
• W2106278322 cites W1489145507 @default.
• W2106278322 cites W154661602 @default.
• W2106278322 cites W1580523172 @default.
• W2106278322 cites W1888905687 @default.
• W2106278322 cites W1922704711 @default.
• W2106278322 cites W1968840300 @default.
• W2106278322 cites W1969097053 @default.
• W2106278322 cites W1971201484 @default.
• W2106278322 cites W1971509596 @default.
• W2106278322 cites W1972178925 @default.
• W2106278322 cites W1988547135 @default.
• W2106278322 cites W1995115168 @default.
• W2106278322 cites W2000586986 @default.
• W2106278322 cites W2002685287 @default.
• W2106278322 cites W2009826571 @default.
• W2106278322 cites W2010421249 @default.
• W2106278322 cites W2012116166 @default.
• W2106278322 cites W2014476883 @default.
• W2106278322 cites W2016277563 @default.
• W2106278322 cites W2024304133 @default.
• W2106278322 cites W2025288244 @default.
• W2106278322 cites W2029014149 @default.
• W2106278322 cites W2049071835 @default.
• W2106278322 cites W2053548194 @default.
• W2106278322 cites W2065173155 @default.
• W2106278322 cites W2068345721 @default.
• W2106278322 cites W2072518443 @default.
• W2106278322 cites W2074369446 @default.
• W2106278322 cites W2076912640 @default.
• W2106278322 cites W2077863736 @default.
• W2106278322 cites W2079010215 @default.
• W2106278322 cites W2087099947 @default.
• W2106278322 cites W2089518544 @default.
• W2106278322 cites W2100237319 @default.
• W2106278322 cites W2102892939 @default.
• W2106278322 cites W2105829250 @default.
• W2106278322 cites W2107633226 @default.
• W2106278322 cites W2116188433 @default.
• W2106278322 cites W2119259534 @default.
• W2106278322 cites W2137035181 @default.
• W2106278322 cites W2137250030 @default.
• W2106278322 cites W2146414563 @default.
• W2106278322 cites W2147073467 @default.
• W2106278322 cites W2152689753 @default.
• W2106278322 cites W2154176338 @default.
• W2106278322 cites W2159196949 @default.
• W2106278322 cites W2159299299 @default.
• W2106278322 cites W2161810908 @default.
• W2106278322 cites W2163148645 @default.
• W2106278322 cites W2167737957 @default.
• W2106278322 cites W300066084 @default.
• W2106278322 doi "https://doi.org/10.1158/0008-5472.can-10-2314" @default.
• W2106278322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3077543" @default.
• W2106278322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21224358" @default.
• W2106278322 hasPublicationYear "2011" @default.
• W2106278322 type Work @default.
• W2106278322 sameAs 2106278322 @default.
• W2106278322 citedByCount "118" @default.
• W2106278322 countsByYear W21062783222012 @default.
• W2106278322 countsByYear W21062783222013 @default.
• W2106278322 countsByYear W21062783222014 @default.
• W2106278322 countsByYear W21062783222015 @default.
• W2106278322 countsByYear W21062783222016 @default.
• W2106278322 countsByYear W21062783222017 @default.
• W2106278322 countsByYear W21062783222018 @default.
• W2106278322 countsByYear W21062783222019 @default.
• W2106278322 countsByYear W21062783222020 @default.
• W2106278322 countsByYear W21062783222021 @default.
• W2106278322 countsByYear W21062783222022 @default.
• W2106278322 countsByYear W21062783222023 @default.
• W2106278322 crossrefType "journal-article" @default.
• W2106278322 hasAuthorship W2106278322A5017754323 @default.
• W2106278322 hasAuthorship W2106278322A5035997680 @default.
• W2106278322 hasAuthorship W2106278322A5036667861 @default.
• W2106278322 hasAuthorship W2106278322A5038117448 @default.
• W2106278322 hasAuthorship W2106278322A5044090270 @default.
• W2106278322 hasAuthorship W2106278322A5061725261 @default.
• W2106278322 hasAuthorship W2106278322A5066263660 @default.
• W2106278322 hasAuthorship W2106278322A5087750113 @default.
• W2106278322 hasAuthorship W2106278322A5088250480 @default.
• W2106278322 hasBestOaLocation W21062783221 @default.
• W2106278322 hasConcept C104317684 @default.
• W2106278322 hasConcept C11960822 @default.
• W2106278322 hasConcept C121608353 @default.

• next