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• W2106279355 abstract "Background Hypertension is one of the most important risk factors for atrial fibrillation ( AF ). Recent studies suggest right atrial remodeling in hypertensive patients may be associated with increased inducibility of AF . This study sought to characterize the electroanatomic features of left and right atria and pulmonary veins ( PVs ) in hypertensive patients. Methods and Results A prospective observational study was conducted on patients who underwent ablation for paroxysmal supraventricular tachycardia or paroxysmal AF . Electrophysiological features of the PV s and atria, including event‐related potentials, conduction time, and inducibility and vulnerability of AF , were characterized during cardiac catheterization. Anatomic and hemodynamic features were assessed by using echocardiographic and computer tomography imaging. When 15 hypertensive patients with paroxysmal supraventricular tachycardia were compared with 17 normotensive patients with paroxysmal supraventricular tachycardia, the hypertensive patients had significantly shortened PV event‐related potentials with increased dispersions ( P <0.001) but slightly prolonged atrial event‐related potentials ( P = NS ) and had prolonged interatrial and intra‐atrial conduction times ( P <0.001). Additionally, the hypertensive patients had increased vulnerability and inducibility of AF and prolonged duration of induced AF ( P <0.01). All of these changes were more pronounced in hypertensive patients with paroxysmal AF . Anatomically, compared with the normotensive patients, the diameters of 4 PV s in the hypertensive patients with paroxysmal supraventricular tachycardia were significantly enlarged ( P <0.01) and became more remarkable in hypertensive patients with paroxysmal AF ( P <0.0001), although the diameter and volume index of the left atrium among 3 groups were similar. Conclusions The hypertensive patients showed electroanatomic changes associated with increased vulnerability to AF , including shortened event‐related potentials with increased dispersion, prolonged conduction time, and increased PV diameter, but these changes were not appreciated in the atria. Additionally, these changes became more dramatic in hypertensive patients with paroxysmal AF ." @default.
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• W2106279355 date "2014-09-16" @default.
• W2106279355 modified "2023-10-16" @default.
• W2106279355 title "The Early Stage of the Atrial Electroanatomic Remodeling as Substrates for Atrial Fibrillation in Hypertensive Patients" @default.
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• W2106279355 doi "https://doi.org/10.1161/jaha.114.001033" @default.
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