FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106308253> ?p ?o ?g. }

• W2106308253 endingPage "421" @default.
• W2106308253 startingPage "412" @default.
• W2106308253 abstract "Treatment for unconjugated hyperbilirubinemia is predominantly based on one parameter, i.e., total serum bilirubin (TSB) levels. Yet, overt kernicterus has been reported in preterm infants at relatively low TSB levels, and it has been repeatedly shown that free unconjugated bilirubin (freeUCB) levels, or bilirubin/albumin (B/A) ratios for that matter, are more closely associated with bilirubin neurotoxicity. In this article, we review bilirubin-albumin binding, UCBfree levels, and B/A ratios in addition to TSB levels to individualize and optimize treatment especially in preterm infants. Methods to measure bilirubin-albumin binding or UCBfree are neither routinely performed in Western clinical laboratories nor incorporated in current management guidelines on unconjugated hyperbilirubinemia. For bilirubin-albumin binding, this seems justified because several of these methods have been challenged, and sufficiently powered prospective trials on the clinical benefits are lacking. Technological advances in the measurement of UCBfree may provide a convenient means for integrating UCBfree measurements into routine clinical management of jaundiced infants. A point-of-care method, as well as determination of UCBfree levels in various newborn populations, is desirable to learn more about variations in time and how various clinical pathophysiological conditions affect UCBfree levels. This will improve the estimation of approximate UCBfree levels associated with neurotoxicity. To delineate the role of UCBfree in the management of jaundiced (preterm) infants, trials are needed using UCBfree as treatment parameter. The additional use of the B/A ratio in jaundiced preterms has been evaluated in the Bilirubin Albumin Ratio Trial (BARTrial; Clinical Trials: ISRCTN74465643) but failed to demonstrate better neurodevelopmental outcome in preterm infants <32 weeks assigned to the study group. Awaiting a study in which infants are assigned to be managed solely on the basis of their B/A ratio (with TSB excluded ) versus TSB levels alone-and determining which group does better-the additional use of the B/A ratio in the management of hyperbilirubinemia in preterms is not advised. In conjunction with TSB levels, other parameters possibly allow for more accurate prediction of bilirubin toxicity. Yet, different methodologies for estimating these parameters exist, and sufficiently powered, prospective clinical trials supporting their clinical benefit, i.e., reduced bilirubin neurotoxicity when using these parameters, are lacking. Their use in addition to TSB needs to be prospectively evaluated, especially in preterm neonates, and preferentially in randomized clinical trials, which include specific risk factors and assessment of clinical relevant outcome measures for detecting those infants at risk of bilirubin toxicity." @default.
• W2106308253 created "2016-06-24" @default.
• W2106308253 creator A5027940792 @default.
• W2106308253 creator A5036020162 @default.
• W2106308253 date "2014-11-01" @default.
• W2106308253 modified "2023-09-24" @default.
• W2106308253 title "Bilirubin–albumin binding, bilirubin/albumin ratios, and free bilirubin levels: Where do we stand?" @default.
• W2106308253 cites W1480814440 @default.
• W2106308253 cites W1483217552 @default.
• W2106308253 cites W1488471704 @default.
• W2106308253 cites W1530884851 @default.
• W2106308253 cites W1538179530 @default.
• W2106308253 cites W1543814240 @default.
• W2106308253 cites W1586037868 @default.
• W2106308253 cites W1587010377 @default.
• W2106308253 cites W1652702275 @default.
• W2106308253 cites W1781966306 @default.
• W2106308253 cites W1911626605 @default.
• W2106308253 cites W1913924927 @default.
• W2106308253 cites W1925181037 @default.
• W2106308253 cites W1929429364 @default.
• W2106308253 cites W1954399659 @default.
• W2106308253 cites W1964098939 @default.
• W2106308253 cites W1971072237 @default.
• W2106308253 cites W1972539504 @default.
• W2106308253 cites W1973553379 @default.
• W2106308253 cites W1973950263 @default.
• W2106308253 cites W1976451021 @default.
• W2106308253 cites W1978194390 @default.
• W2106308253 cites W1981827221 @default.
• W2106308253 cites W1988070929 @default.
• W2106308253 cites W1994044554 @default.
• W2106308253 cites W1995335258 @default.
• W2106308253 cites W1996615898 @default.
• W2106308253 cites W1998014004 @default.
• W2106308253 cites W2006577498 @default.
• W2106308253 cites W2007804932 @default.
• W2106308253 cites W2009351490 @default.
• W2106308253 cites W2011423945 @default.
• W2106308253 cites W2011675772 @default.
• W2106308253 cites W2013121346 @default.
• W2106308253 cites W2018190442 @default.
• W2106308253 cites W2035399758 @default.
• W2106308253 cites W2035871295 @default.
• W2106308253 cites W2037177764 @default.
• W2106308253 cites W2047216789 @default.
• W2106308253 cites W2047823935 @default.
• W2106308253 cites W2054846013 @default.
• W2106308253 cites W2055581554 @default.
• W2106308253 cites W2060241133 @default.
• W2106308253 cites W2063299951 @default.
• W2106308253 cites W2063593430 @default.
• W2106308253 cites W2070267677 @default.
• W2106308253 cites W2073653170 @default.
• W2106308253 cites W2082095730 @default.
• W2106308253 cites W2085653967 @default.
• W2106308253 cites W2086528106 @default.
• W2106308253 cites W2087796453 @default.
• W2106308253 cites W2089865718 @default.
• W2106308253 cites W2092467036 @default.
• W2106308253 cites W2102029794 @default.
• W2106308253 cites W2111994312 @default.
• W2106308253 cites W2116190496 @default.
• W2106308253 cites W2117880641 @default.
• W2106308253 cites W2120000362 @default.
• W2106308253 cites W2120430328 @default.
• W2106308253 cites W2121135858 @default.
• W2106308253 cites W2125123670 @default.
• W2106308253 cites W2126307919 @default.
• W2106308253 cites W2129424806 @default.
• W2106308253 cites W2130759636 @default.
• W2106308253 cites W2133000202 @default.
• W2106308253 cites W2138351652 @default.
• W2106308253 cites W2153579264 @default.
• W2106308253 cites W2155867098 @default.
• W2106308253 cites W2157154175 @default.
• W2106308253 cites W4206412948 @default.
• W2106308253 cites W4206755187 @default.
• W2106308253 cites W4249297046 @default.
• W2106308253 cites W4292078941 @default.
• W2106308253 cites W2028077217 @default.
• W2106308253 doi "https://doi.org/10.1053/j.semperi.2014.08.004" @default.
• W2106308253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25304058" @default.
• W2106308253 hasPublicationYear "2014" @default.
• W2106308253 type Work @default.
• W2106308253 sameAs 2106308253 @default.
• W2106308253 citedByCount "34" @default.
• W2106308253 countsByYear W21063082532014 @default.
• W2106308253 countsByYear W21063082532015 @default.
• W2106308253 countsByYear W21063082532016 @default.
• W2106308253 countsByYear W21063082532017 @default.
• W2106308253 countsByYear W21063082532018 @default.
• W2106308253 countsByYear W21063082532019 @default.
• W2106308253 countsByYear W21063082532020 @default.
• W2106308253 countsByYear W21063082532021 @default.
• W2106308253 countsByYear W21063082532022 @default.
• W2106308253 countsByYear W21063082532023 @default.
• W2106308253 crossrefType "journal-article" @default.

• next