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• W2106312528 abstract "The standardized extract of the St. John's wort plant (Hypericum perforatum) is commonly used to treat mild to moderate depression. Its active constituent is hyperforin, a phloroglucinol derivative that reduces the reuptake of serotonin and norepinephrine by increasing intracellular Na(+) concentration through the activation of nonselective cationic TRPC6 channels. TRPC6 channels are also Ca(2+) -permeable, resulting in intracellular Ca(2+) elevations. Indeed, hyperforin activates TRPC6-mediated currents and Ca(2+) transients in rat PC12 cells, which induce their differentiation, mimicking the neurotrophic effect of nerve growth factor. Here, we show that hyperforin modulates dendritic spine morphology in CA1 and CA3 pyramidal neurons of hippocampal slice cultures through the activation of TRPC6 channels. Hyperforin also evoked intracellular Ca(2+) transients and depolarizing inward currents sensitive to the TRPC channel blocker La(3+) , thus resembling the actions of the neurotrophin brain-derived neurotrophic factor (BDNF) in hippocampal pyramidal neurons. These results suggest that the antidepressant actions of St. John's wort are mediated by a mechanism similar to that engaged by BDNF." @default.
• W2106312528 created "2016-06-24" @default.
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• W2106312528 date "2012-07-20" @default.
• W2106312528 modified "2023-10-17" @default.
• W2106312528 title "Hyperforin modulates dendritic spine morphology in hippocampal pyramidal neurons by activating Ca²⁺‐permeable TRPC6 channels" @default.
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• W2106312528 doi "https://doi.org/10.1002/hipo.22052" @default.
• W2106312528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3538039" @default.
• W2106312528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22815087" @default.
• W2106312528 hasPublicationYear "2012" @default.
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