FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106322567> ?p ?o ?g. }

• W2106322567 endingPage "1897" @default.
• W2106322567 startingPage "1890" @default.
• W2106322567 abstract "BackgroundERp57 is required for platelet function; however, whether ERp57 contributes to fibrin generation is unknown.Methods and ResultsUsing an inhibitory anti‐ERp57 antibody (mAb1), Pf4‐Cre/ERp57fl/fl mice, Tie2‐Cre/ERp57fl/fl mice, and mutants of ERp57, we analyzed the function of ERp57 in laser‐induced thrombosis. Fibrin deposition was decreased in Pf4‐Cre/ERp57fl/fl mice, consistent with a role for platelet ERp57 in fibrin generation. Fibrin deposition was further decreased with infusion of mAb1 and in Tie2‐Cre/ERp57fl/fl mice, consistent with endothelial cells also contributing to fibrin deposition. Infusion of eptibifatide inhibited platelet and fibrin deposition, confirming a role for platelets in fibrin deposition. Infusion of recombinant ERp57 corrected the defect in fibrin deposition but not platelet accumulation, suggesting a direct effect of ERp57 on coagulation. mAb1 inhibited thrombin generation in vitro, consistent with a requirement for ERp57 in coagulation. Platelet accumulation was decreased to similar extents in Pf4‐Cre/ERp57fl/fl mice, Tie2‐Cre/ERp57fl/fl mice and normal mice infused with mAb1. Infusion of completely inactivated ERp57 or ERp57 with a non‐functional second active site inhibited fibrin deposition and platelet accumulation, indicating that the isomerase activity of the second active site is required for these processes.ConclusionERp57 regulates thrombosis via multiple targets." @default.
• W2106322567 created "2016-06-24" @default.
• W2106322567 creator A5029484872 @default.
• W2106322567 creator A5030315782 @default.
• W2106322567 creator A5037540927 @default.
• W2106322567 creator A5039027509 @default.
• W2106322567 creator A5042442712 @default.
• W2106322567 creator A5052209957 @default.
• W2106322567 creator A5075920531 @default.
• W2106322567 date "2014-11-01" @default.
• W2106322567 modified "2023-09-30" @default.
• W2106322567 title "The disulfide isomerase ERp57 is required for fibrin deposition in vivo" @default.
• W2106322567 cites W1495393701 @default.
• W2106322567 cites W1515820929 @default.
• W2106322567 cites W1595540776 @default.
• W2106322567 cites W1607221515 @default.
• W2106322567 cites W1974627917 @default.
• W2106322567 cites W1993305373 @default.
• W2106322567 cites W1996318954 @default.
• W2106322567 cites W2008372909 @default.
• W2106322567 cites W2014164476 @default.
• W2106322567 cites W2022087931 @default.
• W2106322567 cites W2023866211 @default.
• W2106322567 cites W2029875685 @default.
• W2106322567 cites W2030980429 @default.
• W2106322567 cites W2033566611 @default.
• W2106322567 cites W2035400134 @default.
• W2106322567 cites W2035756723 @default.
• W2106322567 cites W2046628294 @default.
• W2106322567 cites W2051677654 @default.
• W2106322567 cites W2059975132 @default.
• W2106322567 cites W2061226552 @default.
• W2106322567 cites W2068593487 @default.
• W2106322567 cites W2071084328 @default.
• W2106322567 cites W2083404164 @default.
• W2106322567 cites W2083430626 @default.
• W2106322567 cites W2088234703 @default.
• W2106322567 cites W2091218840 @default.
• W2106322567 cites W2109503431 @default.
• W2106322567 cites W2119768870 @default.
• W2106322567 cites W2121751288 @default.
• W2106322567 cites W2128054798 @default.
• W2106322567 cites W2134002795 @default.
• W2106322567 cites W2145028149 @default.
• W2106322567 cites W2147613516 @default.
• W2106322567 cites W2158858343 @default.
• W2106322567 cites W2166970179 @default.
• W2106322567 cites W2170756892 @default.
• W2106322567 doi "https://doi.org/10.1111/jth.12709" @default.
• W2106322567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4229395" @default.
• W2106322567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25156521" @default.
• W2106322567 hasPublicationYear "2014" @default.
• W2106322567 type Work @default.
• W2106322567 sameAs 2106322567 @default.
• W2106322567 citedByCount "28" @default.
• W2106322567 countsByYear W21063225672015 @default.
• W2106322567 countsByYear W21063225672016 @default.
• W2106322567 countsByYear W21063225672017 @default.
• W2106322567 countsByYear W21063225672018 @default.
• W2106322567 countsByYear W21063225672019 @default.
• W2106322567 countsByYear W21063225672020 @default.
• W2106322567 countsByYear W21063225672022 @default.
• W2106322567 countsByYear W21063225672023 @default.
• W2106322567 crossrefType "journal-article" @default.
• W2106322567 hasAuthorship W2106322567A5029484872 @default.
• W2106322567 hasAuthorship W2106322567A5030315782 @default.
• W2106322567 hasAuthorship W2106322567A5037540927 @default.
• W2106322567 hasAuthorship W2106322567A5039027509 @default.
• W2106322567 hasAuthorship W2106322567A5042442712 @default.
• W2106322567 hasAuthorship W2106322567A5052209957 @default.
• W2106322567 hasAuthorship W2106322567A5075920531 @default.
• W2106322567 hasBestOaLocation W21063225671 @default.
• W2106322567 hasConcept C126322002 @default.
• W2106322567 hasConcept C153911025 @default.
• W2106322567 hasConcept C185592680 @default.
• W2106322567 hasConcept C203014093 @default.
• W2106322567 hasConcept C2777292125 @default.
• W2106322567 hasConcept C2778382381 @default.
• W2106322567 hasConcept C54173615 @default.
• W2106322567 hasConcept C55493867 @default.
• W2106322567 hasConcept C71924100 @default.
• W2106322567 hasConcept C86803240 @default.
• W2106322567 hasConcept C89560881 @default.
• W2106322567 hasConceptScore W2106322567C126322002 @default.
• W2106322567 hasConceptScore W2106322567C153911025 @default.
• W2106322567 hasConceptScore W2106322567C185592680 @default.
• W2106322567 hasConceptScore W2106322567C203014093 @default.
• W2106322567 hasConceptScore W2106322567C2777292125 @default.
• W2106322567 hasConceptScore W2106322567C2778382381 @default.
• W2106322567 hasConceptScore W2106322567C54173615 @default.
• W2106322567 hasConceptScore W2106322567C55493867 @default.
• W2106322567 hasConceptScore W2106322567C71924100 @default.
• W2106322567 hasConceptScore W2106322567C86803240 @default.
• W2106322567 hasConceptScore W2106322567C89560881 @default.
• W2106322567 hasFunder F4320306230 @default.
• W2106322567 hasFunder F4320321001 @default.
• W2106322567 hasFunder F4320327518 @default.
• W2106322567 hasIssue "11" @default.

• next