FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106331336> ?p ?o ?g. }

• W2106331336 endingPage "1537" @default.
• W2106331336 startingPage "1532" @default.
• W2106331336 abstract "Compound K (CK) is a major intestinal metabolite of ginsenosides derived from ginseng radix. Although antidiabetic and antihyperlipidemic activities of CK have been investigated in recent years, action mechanism of CK remains poorly understood. Therefore, we examined whether CK affects the lipid metabolism in insulin-esistant HepG2 human hepatoma cells. In this study, a significant increase in AMP-activated protein kinase (AMPK) was observed when the cells were treated with CK. Activation of AMPK was also demonstrated by measuring the phosphorylation of acetyl-CoA carboxylase (ACC), a substrate of AMPK. CK attenuated gene expression of sterol regulatory element-binding protein 1c (SREBP1c) in time- and dose-dependent manners. Genes for fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1), well-known target molecules of SREBP1c, were also suppressed. In contrast, gene expressions of peroxisome proliferator-activated receptor α (PPAR-α) and CD36 were increased. These effects were reversed by treatment of compound C, an AMPK inhibitor. However, there were no differences in gene expressions of SREBP2, hydroxymethyl glutaryl CoA reductase (HMGR), and low-density-lipoprotein receptor (LDLR). Taken together, AMPK mediates CK induced suppression and activation of SREBP1c and PPAR-α, respectively, and these effects seem to be one of antidiabetic and/or antihyperlipidemic mechanisms of CK in insulin-resistant HepG2 human hepatoma cells." @default.
• W2106331336 created "2016-06-24" @default.
• W2106331336 creator A5003841787 @default.
• W2106331336 creator A5033415693 @default.
• W2106331336 creator A5059031679 @default.
• W2106331336 creator A5089409792 @default.
• W2106331336 date "2009-02-25" @default.
• W2106331336 modified "2023-10-15" @default.
• W2106331336 title "Compound K, Intestinal Metabolite of Ginsenoside, Attenuates Hepatic Lipid Accumulation via AMPK Activation in Human Hepatoma Cells" @default.
• W2106331336 cites W1565979608 @default.
• W2106331336 cites W1810681069 @default.
• W2106331336 cites W1964959523 @default.
• W2106331336 cites W1975104015 @default.
• W2106331336 cites W1982085282 @default.
• W2106331336 cites W1984985876 @default.
• W2106331336 cites W1990278643 @default.
• W2106331336 cites W1998265190 @default.
• W2106331336 cites W2006336155 @default.
• W2106331336 cites W2010238890 @default.
• W2106331336 cites W2086453930 @default.
• W2106331336 cites W2087332014 @default.
• W2106331336 cites W2095395487 @default.
• W2106331336 cites W2110291449 @default.
• W2106331336 cites W2111445543 @default.
• W2106331336 cites W2135424721 @default.
• W2106331336 cites W2168812832 @default.
• W2106331336 cites W2171407792 @default.
• W2106331336 cites W2615637571 @default.
• W2106331336 doi "https://doi.org/10.1021/jf802867b" @default.
• W2106331336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19182950" @default.
• W2106331336 hasPublicationYear "2009" @default.
• W2106331336 type Work @default.
• W2106331336 sameAs 2106331336 @default.
• W2106331336 citedByCount "97" @default.
• W2106331336 countsByYear W21063313362012 @default.
• W2106331336 countsByYear W21063313362013 @default.
• W2106331336 countsByYear W21063313362014 @default.
• W2106331336 countsByYear W21063313362015 @default.
• W2106331336 countsByYear W21063313362016 @default.
• W2106331336 countsByYear W21063313362017 @default.
• W2106331336 countsByYear W21063313362018 @default.
• W2106331336 countsByYear W21063313362019 @default.
• W2106331336 countsByYear W21063313362020 @default.
• W2106331336 countsByYear W21063313362021 @default.
• W2106331336 countsByYear W21063313362022 @default.
• W2106331336 countsByYear W21063313362023 @default.
• W2106331336 crossrefType "journal-article" @default.
• W2106331336 hasAuthorship W2106331336A5003841787 @default.
• W2106331336 hasAuthorship W2106331336A5033415693 @default.
• W2106331336 hasAuthorship W2106331336A5059031679 @default.
• W2106331336 hasAuthorship W2106331336A5089409792 @default.
• W2106331336 hasConcept C126322002 @default.
• W2106331336 hasConcept C127078168 @default.
• W2106331336 hasConcept C134018914 @default.
• W2106331336 hasConcept C140137476 @default.
• W2106331336 hasConcept C142724271 @default.
• W2106331336 hasConcept C170493617 @default.
• W2106331336 hasConcept C181199279 @default.
• W2106331336 hasConcept C184235292 @default.
• W2106331336 hasConcept C185592680 @default.
• W2106331336 hasConcept C204787440 @default.
• W2106331336 hasConcept C2776780712 @default.
• W2106331336 hasConcept C2777477808 @default.
• W2106331336 hasConcept C2778163477 @default.
• W2106331336 hasConcept C2778718757 @default.
• W2106331336 hasConcept C2779232237 @default.
• W2106331336 hasConcept C2779318131 @default.
• W2106331336 hasConcept C2779828298 @default.
• W2106331336 hasConcept C2780124434 @default.
• W2106331336 hasConcept C4733338 @default.
• W2106331336 hasConcept C48289651 @default.
• W2106331336 hasConcept C55493867 @default.
• W2106331336 hasConcept C71924100 @default.
• W2106331336 hasConcept C85051948 @default.
• W2106331336 hasConcept C86803240 @default.
• W2106331336 hasConcept C97029542 @default.
• W2106331336 hasConceptScore W2106331336C126322002 @default.
• W2106331336 hasConceptScore W2106331336C127078168 @default.
• W2106331336 hasConceptScore W2106331336C134018914 @default.
• W2106331336 hasConceptScore W2106331336C140137476 @default.
• W2106331336 hasConceptScore W2106331336C142724271 @default.
• W2106331336 hasConceptScore W2106331336C170493617 @default.
• W2106331336 hasConceptScore W2106331336C181199279 @default.
• W2106331336 hasConceptScore W2106331336C184235292 @default.
• W2106331336 hasConceptScore W2106331336C185592680 @default.
• W2106331336 hasConceptScore W2106331336C204787440 @default.
• W2106331336 hasConceptScore W2106331336C2776780712 @default.
• W2106331336 hasConceptScore W2106331336C2777477808 @default.
• W2106331336 hasConceptScore W2106331336C2778163477 @default.
• W2106331336 hasConceptScore W2106331336C2778718757 @default.
• W2106331336 hasConceptScore W2106331336C2779232237 @default.
• W2106331336 hasConceptScore W2106331336C2779318131 @default.
• W2106331336 hasConceptScore W2106331336C2779828298 @default.
• W2106331336 hasConceptScore W2106331336C2780124434 @default.
• W2106331336 hasConceptScore W2106331336C4733338 @default.
• W2106331336 hasConceptScore W2106331336C48289651 @default.
• W2106331336 hasConceptScore W2106331336C55493867 @default.
• W2106331336 hasConceptScore W2106331336C71924100 @default.

• next