FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106332008> ?p ?o ?g. }

• W2106332008 endingPage "6151" @default.
• W2106332008 startingPage "6144" @default.
• W2106332008 abstract "Activated neutrophils, recruited to the airway of diseased lung, release human neutrophil peptides (HNP1-4) that are cytotoxic to airway cells as well as microbes. Airway epithelial cells express arginine-specific ADP ribosyltransferase (ART)-1, a GPI-anchored ART that transfers ADP-ribose from NAD to arginines 14 and 24 of HNP-1. We previously reported that ADP-ribosyl-arginine is converted nonenzymatically to ornithine and that ADP-ribosylated HNP-1 and ADP-ribosyl-HNP-(ornithine) were isolated from bronchoalveolar lavage fluid of a patient with idiopathic pulmonary fibrosis, indicating that these reactions occur in vivo. To determine effects of HNP-ornithine on the airway, three analogs of HNP-1, HNP-(R14orn), HNP-(R24orn), and HNP-(R14,24orn), were tested for their activity against Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus aureus; their cytotoxic effects on A549, NCI-H441, small airway epithelial-like cells, and normal human lung fibroblasts; and their ability to stimulate IL-8 and TGF-β1 release from A549 cells, and to serve as ART1 substrates. HNP and the three analogs had similar effects on IL-8 and TGF-β1 release from A549 cells and were all cytotoxic for small airway epithelial cells, NCI-H441, and normal human lung fibroblasts. HNP-(R14,24orn), when compared with HNP-1 and HNP-1 with a single ornithine substitution for arginine 14 or 24, exhibited reduced cytotoxicity, but it enhanced proliferation of A549 cells and had antibacterial activity. Thus, arginines 14 and 24, which can be ADP ribosylated by ART1, are critical to the regulation of the cytotoxic and antibacterial effects of HNP-1. The HNP analog, HNP-(R14,24orn), lacks the epithelial cell cytotoxicity of HNP-1, but partially retains its antibacterial activity and thus may have clinical applications in airway disease." @default.
• W2106332008 created "2016-06-24" @default.
• W2106332008 creator A5015957058 @default.
• W2106332008 creator A5042838294 @default.
• W2106332008 creator A5048042168 @default.
• W2106332008 creator A5073264020 @default.
• W2106332008 creator A5076200634 @default.
• W2106332008 creator A5076520162 @default.
• W2106332008 creator A5079118750 @default.
• W2106332008 date "2014-12-15" @default.
• W2106332008 modified "2023-09-23" @default.
• W2106332008 title "Nonenzymatic Conversion of ADP-Ribosylated Arginines to Ornithine Alters the Biological Activities of Human Neutrophil Peptide-1" @default.
• W2106332008 cites W1502615329 @default.
• W2106332008 cites W1506159034 @default.
• W2106332008 cites W1902412925 @default.
• W2106332008 cites W1967544898 @default.
• W2106332008 cites W1967631524 @default.
• W2106332008 cites W1973279448 @default.
• W2106332008 cites W1974216938 @default.
• W2106332008 cites W1977231563 @default.
• W2106332008 cites W1978484611 @default.
• W2106332008 cites W1989034341 @default.
• W2106332008 cites W1989998611 @default.
• W2106332008 cites W2000193987 @default.
• W2106332008 cites W2002010372 @default.
• W2106332008 cites W2002114986 @default.
• W2106332008 cites W2003361945 @default.
• W2106332008 cites W2011890723 @default.
• W2106332008 cites W2014055037 @default.
• W2106332008 cites W2023022330 @default.
• W2106332008 cites W2029591166 @default.
• W2106332008 cites W2032660941 @default.
• W2106332008 cites W2033815295 @default.
• W2106332008 cites W2033829453 @default.
• W2106332008 cites W2044017031 @default.
• W2106332008 cites W2046071829 @default.
• W2106332008 cites W2056263305 @default.
• W2106332008 cites W2059842188 @default.
• W2106332008 cites W2059941837 @default.
• W2106332008 cites W2060344093 @default.
• W2106332008 cites W2078279181 @default.
• W2106332008 cites W2078558309 @default.
• W2106332008 cites W2080138182 @default.
• W2106332008 cites W2083062699 @default.
• W2106332008 cites W2087442426 @default.
• W2106332008 cites W2103143850 @default.
• W2106332008 cites W2103590204 @default.
• W2106332008 cites W2108105410 @default.
• W2106332008 cites W2109254089 @default.
• W2106332008 cites W2120701526 @default.
• W2106332008 cites W2123814701 @default.
• W2106332008 cites W2125851698 @default.
• W2106332008 cites W2126994657 @default.
• W2106332008 cites W2131158736 @default.
• W2106332008 cites W2138588027 @default.
• W2106332008 cites W2147356893 @default.
• W2106332008 cites W2147657681 @default.
• W2106332008 cites W2147737222 @default.
• W2106332008 cites W2158061050 @default.
• W2106332008 cites W2168686853 @default.
• W2106332008 cites W2183103179 @default.
• W2106332008 cites W2403527161 @default.
• W2106332008 cites W2413870532 @default.
• W2106332008 cites W4246502407 @default.
• W2106332008 doi "https://doi.org/10.4049/jimmunol.1303068" @default.
• W2106332008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6291843" @default.
• W2106332008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25392530" @default.
• W2106332008 hasPublicationYear "2014" @default.
• W2106332008 type Work @default.
• W2106332008 sameAs 2106332008 @default.
• W2106332008 citedByCount "6" @default.
• W2106332008 countsByYear W21063320082016 @default.
• W2106332008 countsByYear W21063320082018 @default.
• W2106332008 countsByYear W21063320082020 @default.
• W2106332008 countsByYear W21063320082021 @default.
• W2106332008 countsByYear W21063320082023 @default.
• W2106332008 crossrefType "journal-article" @default.
• W2106332008 hasAuthorship W2106332008A5015957058 @default.
• W2106332008 hasAuthorship W2106332008A5042838294 @default.
• W2106332008 hasAuthorship W2106332008A5048042168 @default.
• W2106332008 hasAuthorship W2106332008A5073264020 @default.
• W2106332008 hasAuthorship W2106332008A5076200634 @default.
• W2106332008 hasAuthorship W2106332008A5076520162 @default.
• W2106332008 hasAuthorship W2106332008A5079118750 @default.
• W2106332008 hasBestOaLocation W21063320081 @default.
• W2106332008 hasConcept C109316439 @default.
• W2106332008 hasConcept C153911025 @default.
• W2106332008 hasConcept C154317977 @default.
• W2106332008 hasConcept C185592680 @default.
• W2106332008 hasConcept C202751555 @default.
• W2106332008 hasConcept C2776796294 @default.
• W2106332008 hasConcept C2777468819 @default.
• W2106332008 hasConcept C2779281246 @default.
• W2106332008 hasConcept C515207424 @default.
• W2106332008 hasConcept C55493867 @default.
• W2106332008 hasConcept C81729549 @default.
• W2106332008 hasConcept C86803240 @default.
• W2106332008 hasConceptScore W2106332008C109316439 @default.

• next