Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106334513> ?p ?o ?g. }
- W2106334513 endingPage "3060" @default.
- W2106334513 startingPage "3022" @default.
- W2106334513 abstract "Abstract Almost all proteins contain charged amino acids. While the function in catalysis or binding of individual charges in the active site can often be identified, it is less clear how to assign function to charges beyond this region. Are they necessary for solubility? For reasons other than solubility? Can manipulating these charges change the properties of proteins? A combination of capillary electrophoresis (CE) and protein charge ladders makes it possible to study the roles of charged residues on the surface of proteins outside the active site. This method involves chemical modification of those residues to generate a large number of derivatives of the protein that differ in charge. CE separates those derivatives into groups with the same number of modified charged groups. By studying the influence of charge on the properties of proteins using charge ladders, it is possible to estimate the net charge and hydrodynamic radius and to infer the role of charged residues in ligand binding and protein folding." @default.
- W2106334513 created "2016-06-24" @default.
- W2106334513 creator A5023517707 @default.
- W2106334513 creator A5051537916 @default.
- W2106334513 creator A5071393984 @default.
- W2106334513 date "2006-04-27" @default.
- W2106334513 modified "2023-10-18" @default.
- W2106334513 title "Why Are Proteins Charged? Networks of Charge–Charge Interactions in Proteins Measured by Charge Ladders and Capillary Electrophoresis" @default.
- W2106334513 cites W1486913820 @default.
- W2106334513 cites W1504164119 @default.
- W2106334513 cites W1526669805 @default.
- W2106334513 cites W1537478644 @default.
- W2106334513 cites W1548084462 @default.
- W2106334513 cites W1548718817 @default.
- W2106334513 cites W1549224984 @default.
- W2106334513 cites W1568427065 @default.
- W2106334513 cites W1576127641 @default.
- W2106334513 cites W157808733 @default.
- W2106334513 cites W1581818288 @default.
- W2106334513 cites W1602954239 @default.
- W2106334513 cites W1836923993 @default.
- W2106334513 cites W187801720 @default.
- W2106334513 cites W1926033671 @default.
- W2106334513 cites W1931164952 @default.
- W2106334513 cites W1965819236 @default.
- W2106334513 cites W1965920961 @default.
- W2106334513 cites W1966964730 @default.
- W2106334513 cites W1968280815 @default.
- W2106334513 cites W1970683586 @default.
- W2106334513 cites W1970948529 @default.
- W2106334513 cites W1971345772 @default.
- W2106334513 cites W1971366619 @default.
- W2106334513 cites W1971392741 @default.
- W2106334513 cites W1971420682 @default.
- W2106334513 cites W1972053762 @default.
- W2106334513 cites W1974537934 @default.
- W2106334513 cites W1974853420 @default.
- W2106334513 cites W1976406451 @default.
- W2106334513 cites W1976517281 @default.
- W2106334513 cites W1977214956 @default.
- W2106334513 cites W1977811526 @default.
- W2106334513 cites W1978101105 @default.
- W2106334513 cites W1978807770 @default.
- W2106334513 cites W1979318581 @default.
- W2106334513 cites W1980530846 @default.
- W2106334513 cites W1981575136 @default.
- W2106334513 cites W1981721404 @default.
- W2106334513 cites W1981925074 @default.
- W2106334513 cites W1983663894 @default.
- W2106334513 cites W1984903816 @default.
- W2106334513 cites W1985724808 @default.
- W2106334513 cites W1987729396 @default.
- W2106334513 cites W1988523134 @default.
- W2106334513 cites W1988951105 @default.
- W2106334513 cites W1989861229 @default.
- W2106334513 cites W1990202641 @default.
- W2106334513 cites W1992099050 @default.
- W2106334513 cites W1992681077 @default.
- W2106334513 cites W1993004025 @default.
- W2106334513 cites W1994081877 @default.
- W2106334513 cites W1994144261 @default.
- W2106334513 cites W1994209760 @default.
- W2106334513 cites W1994292154 @default.
- W2106334513 cites W1994711141 @default.
- W2106334513 cites W1994890799 @default.
- W2106334513 cites W1995429477 @default.
- W2106334513 cites W1995436342 @default.
- W2106334513 cites W1995637578 @default.
- W2106334513 cites W1995987600 @default.
- W2106334513 cites W1996874053 @default.
- W2106334513 cites W1997265863 @default.
- W2106334513 cites W1998307511 @default.
- W2106334513 cites W1998649776 @default.
- W2106334513 cites W2001166060 @default.
- W2106334513 cites W2001774242 @default.
- W2106334513 cites W2002659345 @default.
- W2106334513 cites W2002841488 @default.
- W2106334513 cites W2003955698 @default.
- W2106334513 cites W2005243185 @default.
- W2106334513 cites W2005315204 @default.
- W2106334513 cites W2005818688 @default.
- W2106334513 cites W2006102192 @default.
- W2106334513 cites W2006747142 @default.
- W2106334513 cites W2006975013 @default.
- W2106334513 cites W2007316441 @default.
- W2106334513 cites W2010224825 @default.
- W2106334513 cites W2010587968 @default.
- W2106334513 cites W2010597259 @default.
- W2106334513 cites W2010711204 @default.
- W2106334513 cites W2011435358 @default.
- W2106334513 cites W2013263481 @default.
- W2106334513 cites W2013436066 @default.
- W2106334513 cites W2013931680 @default.
- W2106334513 cites W2015039690 @default.
- W2106334513 cites W2015365877 @default.
- W2106334513 cites W2016051727 @default.
- W2106334513 cites W2017212707 @default.
- W2106334513 cites W2017292508 @default.