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- W2106339969 abstract "Abstract— Axonal transport of lipids was demonstrated in the rabbit optic system using [2-3H]glycerol and [3-14C]serine. Following intraocular injection of these precursors, radioactive lipids were detected in the optic tract, superior colliculus and lateral geniculate body over a 31 day period. The bulk of lipid appeared to migrate at a rate equivalent to that of rapidly transported protein which, when combined with a prolonged period of release into the axon, led to a peak of transported radioactivity at 6-10 days for the 3 tissues. The suggestion of a second peak at 17 days indicated the possibility of a smaller slow component, although another interpretation is suggested. Analysis of individual transported lipids revealed [2-3H]glycerol to label phosphoglycerides preferentially and [3-14C]serine to be an effective precursor for sphingolipids and certain of the phosphoglycerides. [3-14C]Serine labeled axonally transported proteins to an even greater extent than lipids, revealing the same fast and slow components previously shown with other amino acids." @default.
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- W2106339969 date "1979-03-01" @default.
- W2106339969 modified "2023-09-25" @default.
- W2106339969 title "AXONAL TRANSPORT OF LIPIDS IN THE RABBIT OPTIC SYSTEM" @default.
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- W2106339969 doi "https://doi.org/10.1111/j.1471-4159.1979.tb04555.x" @default.
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