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- W2106361984 abstract "1 The effects of caffeine and other methylxanthines were investigated on intracellular calcium concentration ([Ca2+]i) and contraction in rat isolated ventricular myocytes. The use of the fluorescent indicator, Indo-1, allowed simultaneous measurement of [Ca2+]i and the intracellular concentration of the methylxanthines. 2 Rapid application of caffeine (10 mm) produced a transient rise of [Ca2+]i which decayed to resting levels. This was accompanied by a transient contraction which decayed to a level above baseline. The addition of theophylline also produced a transient increase of [Ca2+]i. However, following the initial transient, contraction decayed before redeveloping to a maintained level. 3 Direct measurements showed that [caffeine]i rose more quickly than did [theophylline]i. The slower rise of [theophylline]i was associated with a delay in the increase of [Ca2+]i. At lower concentrations of the methylxanthines, theophylline was less effective than caffeine at initiating Ca release. The rate of entry of theobromine was similar to that of theophylline. 4 Isocaffeine did not produce a rise of [Ca2+]i. The rate of rise of [isocaffeine]i was much slower than that of either caffeine or theophylline. 5 Measurements of the oil:water partition coefficient showed that the order of relative partitioning into oil was: caffeine < theophylline < theobromine > isocaffeine. This is similar to the order of rate of entry into the cell. 6 We conclude that many of the differences in the effects of these methylxanthines can be attributed to differences in membrane permeability due to differences in oil:water partition." @default.
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- W2106361984 date "1994-02-01" @default.
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- W2106361984 title "Comparison of the effects of caffeine and other methylxanthines on [Ca2+]i in rat ventricular myocytes" @default.
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- W2106361984 doi "https://doi.org/10.1111/j.1476-5381.1994.tb14757.x" @default.
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