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- W2106364785 abstract "Astaxanthin and peridinin, two typical carotenoids of marine microalgae, and lycopene were incorporated in phosphatidylcholine multilamellar liposomes and tested as inhibitors of lipid oxidation. Contrarily to peridinin results, astaxanthin strongly reduced lipid damage when the lipoperoxidation promoters-H(2)O(2), tert-butyl hydroperoxide (t-ButOOH) or ascorbate-and Fe(2+):EDTA were added simultaneously to the liposomes. In order to check if the antioxidant activity of carotenoids was also related to their effect on membrane permeability, the peroxidation processes were initiated by adding the promoters to Fe(2+)-loaded liposomes (encapsulated in the inner aqueous solution). Despite that the rigidifying effect of carotenoids in membranes was not directly measured here, peridinin probably has decreased membrane permeability to initiators (t-ButOOH > ascorbate > H(2)O(2)) since its incorporation limited oxidative damage on iron-liposomes. On the other hand, the antioxidant activity of astaxanthin in iron-containing vesicles might be derived from its known rigidifying effect and the inherent scavenging ability." @default.
- W2106364785 created "2016-06-24" @default.
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- W2106364785 date "2001-10-01" @default.
- W2106364785 modified "2023-10-02" @default.
- W2106364785 title "Astaxanthin and Peridinin Inhibit Oxidative Damage in Fe2+-Loaded Liposomes: Scavenging Oxyradicals or Changing Membrane Permeability?" @default.
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- W2106364785 doi "https://doi.org/10.1006/bbrc.2001.5765" @default.
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