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• W2106376098 abstract "1 Activation of pre-junctional α-adrenoceptors at the skeletal neuromuscular junction enhances acetylcholine release whereas activation of such receptors at autonomic nerve endings inhibits transmitter output. In the present study the characteristics of pre-junctional α-adrenoceptors at motor nerve terminals have been compared with post-junctional (vascular) α-adrenoceptors*in the cat hind limb. 2 Reversal of partial (-I-)-tubocurarine blockade of contractions of the tibialis anterior muscle was used to monitor pre-junctional activity and increases in hindlimb vascular resistance to assess post-junctional actions at α-adrenoceptors. 3 Responses to intra-arterial injections of noradrenaline, adrenaline, phenylephrine, oxymetazoline, methoxamine and clonidine were monitored. Dose-response lines for all the compounds except clonidine were parallel. The latter agent produced only weak and inconsistent effects. 4 Ratios of the doses of the agents required to produce pre- and post-junctional effects indicated that oxymetazoline and adrenaline possessed some preferential activity at post-junctional sites, whereas the remaining agents were non-selective in their actions. If dose-ratios with respect to noradrenaline were compared at the two sites none of the compounds possessed a marked degree of selectivity. 5 In the presence of phentolamine or tolazoline, dose-response curves to the pre- and post-junctional effects of phenylephrine were shifted to a similar extent. Thymoxamine showed preferential activity as a pre-junctionalα-receptor antagonist. 6 In comparing the results of this study with those of other authors, it is apparent that there are marked differences in the characteristics of pre-junctionalα-receptors at the skeletal neuromuscular junction and at autonomic nerve endings. The pre- and post-junctionalα-receptors in skeletal muscle show less divergence." @default.
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• W2106376098 title "COMPARISON OF PREJUNCTIONALα-ADRENOCEPTORS AT THE NEUROMUSCULAR JUNCTION WITH VASCULAR POSTJUNCTIONALα-RECEPTORS IN CAT SKELETAL MUSCLE" @default.
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• W2106376098 doi "https://doi.org/10.1111/j.1476-5381.1979.tb07825.x" @default.
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