FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106405175> ?p ?o ?g. }

• W2106405175 abstract "Envenomations caused by different species of Bothrops snakes result in severe local tissue damage, hemorrhage, pain, myonecrosis, and inflammation with a significant leukocyte accumulation at the bite site. However, the activation state of leukocytes is still unclear. According to clinical cases and experimental work, the local effects observed in envenenomation by Bothrops alternatus are mainly the appearance of edema, hemorrhage, and necrosis. In this study we investigated the ability of Bothrops alternatus crude venom to induce macrophage activation. At 6 to 100 ¼g/mL, BaV is not toxic to thioglycollate-elicited macrophages; at 3 and 6 ¼g/mL, it did not interfere in macrophage adhesion or detachment. Moreover, at concentrations of 1.5, 3, and 6 ¼g/mL the venom induced an increase in phagocytosis via complement receptor one hour after incubation. Pharmacological treatment of thioglycollate-elicited macrophages with staurosporine, a protein kinase (PKC) inhibitor, abolished phagocytosis, suggesting that PKC may be involved in the increase of serum-opsonized zymosan phagocytosis induced by BaV. Moreover, BaV also induced the production of anion superoxide (O2_) by thioglycollate-elicited macrophages. This BaV stimulated superoxide production was abolished after treating the cells with staurosporine, indicating that PKC is an important signaling pathway for the production of this radical. Based on these results, we suggest that phagocytosis and reactive oxygen species are involved in the pathogenesis of local tissue damage characteristic of Bothrops spp. envenomations." @default.
• W2106405175 created "2016-06-24" @default.
• W2106405175 creator A5017990104 @default.
• W2106405175 creator A5029635404 @default.
• W2106405175 creator A5037014034 @default.
• W2106405175 creator A5046635780 @default.
• W2106405175 creator A5087418105 @default.
• W2106405175 creator A5090104211 @default.
• W2106405175 date "2011-01-01" @default.
• W2106405175 modified "2023-09-27" @default.
• W2106405175 cites W14263565 @default.
• W2106405175 cites W1493190301 @default.
• W2106405175 cites W1510633031 @default.
• W2106405175 cites W1576671418 @default.
• W2106405175 cites W1578880018 @default.
• W2106405175 cites W1586099293 @default.
• W2106405175 cites W1807368877 @default.
• W2106405175 cites W1869540660 @default.
• W2106405175 cites W187420443 @default.
• W2106405175 cites W1874751834 @default.
• W2106405175 cites W1892779445 @default.
• W2106405175 cites W1964974360 @default.
• W2106405175 cites W1965286141 @default.
• W2106405175 cites W1969637864 @default.
• W2106405175 cites W1969901996 @default.
• W2106405175 cites W1972658995 @default.
• W2106405175 cites W1978092409 @default.
• W2106405175 cites W1985922827 @default.
• W2106405175 cites W1988940275 @default.
• W2106405175 cites W1990420775 @default.
• W2106405175 cites W1996535022 @default.
• W2106405175 cites W2000754365 @default.
• W2106405175 cites W2003342830 @default.
• W2106405175 cites W2003602248 @default.
• W2106405175 cites W2007705388 @default.
• W2106405175 cites W2019552956 @default.
• W2106405175 cites W2020914789 @default.
• W2106405175 cites W2020924218 @default.
• W2106405175 cites W2022329243 @default.
• W2106405175 cites W2024599485 @default.
• W2106405175 cites W2028080793 @default.
• W2106405175 cites W2034453407 @default.
• W2106405175 cites W2035413309 @default.
• W2106405175 cites W2043071886 @default.
• W2106405175 cites W2043383369 @default.
• W2106405175 cites W2049206748 @default.
• W2106405175 cites W2056751071 @default.
• W2106405175 cites W2058379571 @default.
• W2106405175 cites W2063364842 @default.
• W2106405175 cites W2064304429 @default.
• W2106405175 cites W2065933401 @default.
• W2106405175 cites W2066887132 @default.
• W2106405175 cites W2069309423 @default.
• W2106405175 cites W2073561567 @default.
• W2106405175 cites W2074886945 @default.
• W2106405175 cites W2075477360 @default.
• W2106405175 cites W2075595064 @default.
• W2106405175 cites W2078990860 @default.
• W2106405175 cites W2082920258 @default.
• W2106405175 cites W2092361028 @default.
• W2106405175 cites W2097877636 @default.
• W2106405175 cites W2102538853 @default.
• W2106405175 cites W2103983147 @default.
• W2106405175 cites W2107756617 @default.
• W2106405175 cites W2109519875 @default.
• W2106405175 cites W2110659553 @default.
• W2106405175 cites W2110770741 @default.
• W2106405175 cites W2115993724 @default.
• W2106405175 cites W2117966002 @default.
• W2106405175 cites W2132696478 @default.
• W2106405175 cites W2136731274 @default.
• W2106405175 cites W2137882233 @default.
• W2106405175 cites W2141605856 @default.
• W2106405175 cites W2154415816 @default.
• W2106405175 cites W2167548726 @default.
• W2106405175 cites W2172982769 @default.
• W2106405175 cites W2261552086 @default.
• W2106405175 cites W2397316750 @default.
• W2106405175 cites W2409949572 @default.
• W2106405175 cites W2416933012 @default.
• W2106405175 cites W2417898629 @default.
• W2106405175 cites W2025523788 @default.
• W2106405175 doi "https://doi.org/10.1590/s1678-91992011000400010" @default.
• W2106405175 hasPublicationYear "2011" @default.
• W2106405175 type Work @default.
• W2106405175 sameAs 2106405175 @default.
• W2106405175 citedByCount "5" @default.
• W2106405175 countsByYear W21064051752012 @default.
• W2106405175 countsByYear W21064051752019 @default.
• W2106405175 countsByYear W21064051752021 @default.
• W2106405175 countsByYear W21064051752022 @default.
• W2106405175 crossrefType "journal-issue" @default.
• W2106405175 hasAuthorship W2106405175A5017990104 @default.
• W2106405175 hasAuthorship W2106405175A5029635404 @default.
• W2106405175 hasAuthorship W2106405175A5037014034 @default.
• W2106405175 hasAuthorship W2106405175A5046635780 @default.
• W2106405175 hasAuthorship W2106405175A5087418105 @default.
• W2106405175 hasAuthorship W2106405175A5090104211 @default.
• W2106405175 hasBestOaLocation W21064051751 @default.
• W2106405175 hasConcept C145600735 @default.

• next