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- W2106411985 abstract "Although the exact functions of sleep remain a topic of debate, several hypotheses propose that sleep benefits neuronal plasticity, which ultimately supports brain function and cognitionCognition . For over a century, researchers have applied a wide variety of behavioral, electrophysiological, biochemical, and molecular approaches to study how memoryMemory processes are promoted by sleep and perturbed by sleep loss. Interestingly, experimental studies indicate that cognitive impairments as a consequence of sleep deprivation appear to be most severe with learningLearning and memory processes that require the hippocampushippocampus , which suggests that this brain region is particularly sensitive to the consequences of sleep loss. Moreover, recent studies in laboratory rodents indicate that sleep deprivation impairs hippocampal neuronal plasticity and memory processes by attenuating intracellular cyclic adenosine monophosphate (cAMPcAMP )-protein kinase A (PKAPKA ) signaling. Attenuated cAMP-PKA signalingcAMP-PKA signaling can lead to a reduced activity of the transcription factor cAMP response element binding protein (CREBCREB ) and ultimately affect the expression of genes and proteins involved in neuronal plasticity and memory formation. Pharmacogenetic experiments in mice show that memory deficits following sleep deprivation can be prevented by specifically boosting cAMP signaling in excitatory neurons of the hippocampus. Given the high incidence of sleep disturbance and sleep restriction in our 24/7 society, understanding the consequences of sleep loss and unraveling the underlying molecular mechanisms is of great importance." @default.
- W2106411985 created "2016-06-24" @default.
- W2106411985 creator A5012830746 @default.
- W2106411985 creator A5017550855 @default.
- W2106411985 creator A5035415831 @default.
- W2106411985 date "2015-01-01" @default.
- W2106411985 modified "2023-10-17" @default.
- W2106411985 title "Animal Studies on the Role of Sleep in Memory: From Behavioral Performance to Molecular Mechanisms" @default.
- W2106411985 cites W1521789748 @default.
- W2106411985 cites W1535059925 @default.
- W2106411985 cites W1539823279 @default.
- W2106411985 cites W1545533518 @default.
- W2106411985 cites W1600959743 @default.
- W2106411985 cites W1609834322 @default.
- W2106411985 cites W1660095449 @default.
- W2106411985 cites W1664641772 @default.
- W2106411985 cites W1863554980 @default.
- W2106411985 cites W1949317008 @default.
- W2106411985 cites W1964239211 @default.
- W2106411985 cites W1966265284 @default.
- W2106411985 cites W1967872727 @default.
- W2106411985 cites W1970682202 @default.
- W2106411985 cites W1975818747 @default.
- W2106411985 cites W1977293696 @default.
- W2106411985 cites W1979530444 @default.
- W2106411985 cites W1982765883 @default.
- W2106411985 cites W1986141745 @default.
- W2106411985 cites W1986265386 @default.
- W2106411985 cites W1992821016 @default.
- W2106411985 cites W1992958536 @default.
- W2106411985 cites W1993135690 @default.
- W2106411985 cites W2000269220 @default.
- W2106411985 cites W2001484935 @default.
- W2106411985 cites W2002927748 @default.
- W2106411985 cites W2003856118 @default.
- W2106411985 cites W2004483169 @default.
- W2106411985 cites W2008030090 @default.
- W2106411985 cites W2008505292 @default.
- W2106411985 cites W2015592781 @default.
- W2106411985 cites W2016469892 @default.
- W2106411985 cites W2017169966 @default.
- W2106411985 cites W2017197169 @default.
- W2106411985 cites W2017764061 @default.
- W2106411985 cites W2024479961 @default.
- W2106411985 cites W2024758252 @default.
- W2106411985 cites W2026609418 @default.
- W2106411985 cites W2027288004 @default.
- W2106411985 cites W2027731726 @default.
- W2106411985 cites W2032792654 @default.
- W2106411985 cites W2033136528 @default.
- W2106411985 cites W2035300025 @default.
- W2106411985 cites W2041639784 @default.
- W2106411985 cites W2042894225 @default.
- W2106411985 cites W2045815714 @default.
- W2106411985 cites W2060763281 @default.
- W2106411985 cites W2065136892 @default.
- W2106411985 cites W2067738389 @default.
- W2106411985 cites W2067753351 @default.
- W2106411985 cites W2067780273 @default.
- W2106411985 cites W2070324748 @default.
- W2106411985 cites W2071215075 @default.
- W2106411985 cites W2075732211 @default.
- W2106411985 cites W2075808524 @default.
- W2106411985 cites W2078414327 @default.
- W2106411985 cites W2083143366 @default.
- W2106411985 cites W2084993455 @default.
- W2106411985 cites W2087321410 @default.
- W2106411985 cites W2087499137 @default.
- W2106411985 cites W2087819096 @default.
- W2106411985 cites W2091898070 @default.
- W2106411985 cites W2094483645 @default.
- W2106411985 cites W2095793145 @default.
- W2106411985 cites W2096232633 @default.
- W2106411985 cites W2096943065 @default.
- W2106411985 cites W2103713548 @default.
- W2106411985 cites W2103743177 @default.
- W2106411985 cites W2109919607 @default.
- W2106411985 cites W2116242222 @default.
- W2106411985 cites W2119835435 @default.
- W2106411985 cites W2120144854 @default.
- W2106411985 cites W2120550234 @default.
- W2106411985 cites W2120605643 @default.
- W2106411985 cites W2123066014 @default.
- W2106411985 cites W2124004131 @default.
- W2106411985 cites W2125252313 @default.
- W2106411985 cites W2127550021 @default.
- W2106411985 cites W2128797181 @default.
- W2106411985 cites W2129059324 @default.
- W2106411985 cites W2129084135 @default.
- W2106411985 cites W2138032667 @default.
- W2106411985 cites W2138560354 @default.
- W2106411985 cites W2140117942 @default.
- W2106411985 cites W2145092284 @default.
- W2106411985 cites W2146047911 @default.
- W2106411985 cites W2153495355 @default.
- W2106411985 cites W2153833997 @default.
- W2106411985 cites W2154323234 @default.
- W2106411985 cites W2154457867 @default.