FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106435662> ?p ?o ?g. }

• W2106435662 endingPage "493" @default.
• W2106435662 startingPage "487" @default.
• W2106435662 abstract "cAMP controls many cellular processes mainly through the activation of protein kinase A (PKA). However, more recently PKA-independent pathways have been established through the exchange protein directly activated by cAMP (Epac), a guanine nucleotide exchange factor for the small GTPases Rap1 and Rap2. In this report, we show that cAMP can induce integrin-mediated cell adhesion through Epac and Rap1. Indeed, when Ovcar3 cells were treated with cAMP, cells adhered more rapidly to fibronectin. This cAMP effect was insensitive to the PKA inhibitor H-89. A similar increase was observed when the cells were transfected with Epac. Both the cAMP effect and the Epac effect on cell adhesion were abolished by the expression of Rap1-GTPase-activating protein, indicating the involvement of Rap1 in the signaling pathway. Importantly, a recently characterized cAMP analogue, 8-(4-chloro-phenylthio)-2'-O-methyladenosine-3',5'-cyclic monophosphate, which specifically activates Epac but not PKA, induced Rap-dependent cell adhesion. Finally, we demonstrate that external stimuli of cAMP signaling, i.e., isoproterenol, which activates the G alpha s-coupled beta 2-adrenergic receptor can induce integrin-mediated cell adhesion through the Epac-Rap1 pathway. From these results we conclude that cAMP mediates receptor-induced integrin-mediated cell adhesion to fibronectin through the Epac-Rap1 signaling pathway." @default.
• W2106435662 created "2016-06-24" @default.
• W2106435662 creator A5000581416 @default.
• W2106435662 creator A5012633181 @default.
• W2106435662 creator A5037487077 @default.
• W2106435662 creator A5049654018 @default.
• W2106435662 creator A5071743755 @default.
• W2106435662 creator A5080949553 @default.
• W2106435662 creator A5087017498 @default.
• W2106435662 date "2003-02-10" @default.
• W2106435662 modified "2023-10-11" @default.
• W2106435662 title "Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the β2-adrenergic receptor" @default.
• W2106435662 cites W1487918137 @default.
• W2106435662 cites W1498760971 @default.
• W2106435662 cites W1544549727 @default.
• W2106435662 cites W1560618466 @default.
• W2106435662 cites W1564772833 @default.
• W2106435662 cites W1815337088 @default.
• W2106435662 cites W1885709862 @default.
• W2106435662 cites W1970258936 @default.
• W2106435662 cites W1978467605 @default.
• W2106435662 cites W1989046246 @default.
• W2106435662 cites W1994816216 @default.
• W2106435662 cites W2001640037 @default.
• W2106435662 cites W2012806962 @default.
• W2106435662 cites W2013549218 @default.
• W2106435662 cites W2016775197 @default.
• W2106435662 cites W2028242823 @default.
• W2106435662 cites W2034900375 @default.
• W2106435662 cites W2039629780 @default.
• W2106435662 cites W2063193026 @default.
• W2106435662 cites W2075158125 @default.
• W2106435662 cites W2075823443 @default.
• W2106435662 cites W2078037416 @default.
• W2106435662 cites W2083063047 @default.
• W2106435662 cites W2095430146 @default.
• W2106435662 cites W2097877636 @default.
• W2106435662 cites W2109319033 @default.
• W2106435662 cites W2118399632 @default.
• W2106435662 cites W2143563119 @default.
• W2106435662 cites W2149334247 @default.
• W2106435662 cites W2153283433 @default.
• W2106435662 cites W2346147167 @default.
• W2106435662 cites W4214835361 @default.
• W2106435662 cites W4236446158 @default.
• W2106435662 doi "https://doi.org/10.1083/jcb.200209105" @default.
• W2106435662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2173739" @default.
• W2106435662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12578910" @default.
• W2106435662 hasPublicationYear "2003" @default.
• W2106435662 type Work @default.
• W2106435662 sameAs 2106435662 @default.
• W2106435662 citedByCount "256" @default.
• W2106435662 countsByYear W21064356622012 @default.
• W2106435662 countsByYear W21064356622013 @default.
• W2106435662 countsByYear W21064356622014 @default.
• W2106435662 countsByYear W21064356622015 @default.
• W2106435662 countsByYear W21064356622016 @default.
• W2106435662 countsByYear W21064356622017 @default.
• W2106435662 countsByYear W21064356622018 @default.
• W2106435662 countsByYear W21064356622019 @default.
• W2106435662 countsByYear W21064356622020 @default.
• W2106435662 countsByYear W21064356622021 @default.
• W2106435662 countsByYear W21064356622022 @default.
• W2106435662 countsByYear W21064356622023 @default.
• W2106435662 crossrefType "journal-article" @default.
• W2106435662 hasAuthorship W2106435662A5000581416 @default.
• W2106435662 hasAuthorship W2106435662A5012633181 @default.
• W2106435662 hasAuthorship W2106435662A5037487077 @default.
• W2106435662 hasAuthorship W2106435662A5049654018 @default.
• W2106435662 hasAuthorship W2106435662A5071743755 @default.
• W2106435662 hasAuthorship W2106435662A5080949553 @default.
• W2106435662 hasAuthorship W2106435662A5087017498 @default.
• W2106435662 hasBestOaLocation W21064356621 @default.
• W2106435662 hasConcept C126619667 @default.
• W2106435662 hasConcept C1491633281 @default.
• W2106435662 hasConcept C170493617 @default.
• W2106435662 hasConcept C184235292 @default.
• W2106435662 hasConcept C189165786 @default.
• W2106435662 hasConcept C195687474 @default.
• W2106435662 hasConcept C2776179587 @default.
• W2106435662 hasConcept C2780298669 @default.
• W2106435662 hasConcept C55493867 @default.
• W2106435662 hasConcept C62478195 @default.
• W2106435662 hasConcept C85789140 @default.
• W2106435662 hasConcept C86492073 @default.
• W2106435662 hasConcept C86803240 @default.
• W2106435662 hasConcept C95444343 @default.
• W2106435662 hasConcept C97029542 @default.
• W2106435662 hasConceptScore W2106435662C126619667 @default.
• W2106435662 hasConceptScore W2106435662C1491633281 @default.
• W2106435662 hasConceptScore W2106435662C170493617 @default.
• W2106435662 hasConceptScore W2106435662C184235292 @default.
• W2106435662 hasConceptScore W2106435662C189165786 @default.
• W2106435662 hasConceptScore W2106435662C195687474 @default.
• W2106435662 hasConceptScore W2106435662C2776179587 @default.
• W2106435662 hasConceptScore W2106435662C2780298669 @default.
• W2106435662 hasConceptScore W2106435662C55493867 @default.
• W2106435662 hasConceptScore W2106435662C62478195 @default.

• next