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- W2106442761 abstract "ABSTRACT Accidental cell death often leads to compensatory proliferation. In Drosophila imaginal discs, for example, γ-irradiation induces extensive cell death, which is rapidly compensated by elevated proliferation. Excessive compensatory proliferation can be artificially induced by “undead cells” that are kept alive by inhibition of effector caspases in the presence of apoptotic stimuli. This suggests that compensatory proliferation is induced by dying cells as part of the apoptosis program. Here, we provide genetic evidence that the Drosophila initiator caspase DRONC governs both apoptosis execution and subsequent compensatory proliferation. We examined mutants of five Drosophila caspases and identified the initiator caspase DRONC and the effector caspase DRICE as crucial executioners of apoptosis. Artificial compensatory proliferation induced by coexpression of Reaper and p35 was completely suppressed in dronc mutants. Moreover, compensatory proliferation after γ-irradiation was enhanced in drice mutants, in which DRONC is activated but the cells remain alive. These results show that the apoptotic pathway bifurcates at DRONC and that DRONC coordinates the execution of cell death and compensatory proliferation." @default.
- W2106442761 created "2016-06-24" @default.
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- W2106442761 creator A5024331685 @default.
- W2106442761 creator A5025150156 @default.
- W2106442761 creator A5082953317 @default.
- W2106442761 date "2006-10-01" @default.
- W2106442761 modified "2023-10-11" @default.
- W2106442761 title "DRONC Coordinates Cell Death and Compensatory Proliferation" @default.
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- W2106442761 doi "https://doi.org/10.1128/mcb.00183-06" @default.
- W2106442761 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1592896" @default.
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