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- W2106450152 abstract "Chronic inflammation drives the development of various pathological diseases such as rheumatoid arthritis, atherosclerosis, multiple sclerosis, and cancer. The arachidonic acid pathway represents one of the major mechanisms for inflammation. Prostaglandins (PGs) are lipid products generated from arachidonic acid by the action of cyclooxygenase (COX) enzymes and their activity is blocked by nonsteroidal anti-inflammatory drugs (NSAIDS). The use of natural compounds in regulation of COX activity/prostaglandins production is receiving increasing attention. In Mediterranean diet, olive oil and table olives contain significant dietary sources of maslinic acid. Maslinic acid is arising as a safe and novel natural pentacyclic triterpene which has protective effects against chronic inflammatory diseases in various in vivo and in vitro experimental models. Understanding the anti-inflammatory mechanism of maslinic acid is crucial for its development as a potential dietary nutraceutical. This review focuses on the mechanistic action of maslinic acid in regulating the inflammation pathways through modulation of the arachidonic acid metabolism including the nuclear factor-kappa B (NF-κB)/COX-2 expression, upstream protein kinase signaling, and phospholipase A2 enzyme activity. Further investigations may provide insight into the mechanism of maslinic acid in regulating the molecular targets and their associated pathways in response to specific inflammatory stimuli." @default.
- W2106450152 created "2016-06-24" @default.
- W2106450152 creator A5011938519 @default.
- W2106450152 creator A5019172467 @default.
- W2106450152 date "2015-01-01" @default.
- W2106450152 modified "2023-10-18" @default.
- W2106450152 title "Mechanistic Perspectives of Maslinic Acid in Targeting Inflammation" @default.
- W2106450152 cites W126816316 @default.
- W2106450152 cites W1495576061 @default.
- W2106450152 cites W1552867332 @default.
- W2106450152 cites W1644155262 @default.
- W2106450152 cites W1837325383 @default.
- W2106450152 cites W1942930266 @default.
- W2106450152 cites W1966060541 @default.
- W2106450152 cites W1966556984 @default.
- W2106450152 cites W1972505498 @default.
- W2106450152 cites W1974255525 @default.
- W2106450152 cites W1979654645 @default.
- W2106450152 cites W1984062654 @default.
- W2106450152 cites W1989351016 @default.
- W2106450152 cites W1990583867 @default.
- W2106450152 cites W1994497941 @default.
- W2106450152 cites W1997421363 @default.
- W2106450152 cites W1999177172 @default.
- W2106450152 cites W2002461979 @default.
- W2106450152 cites W2002708977 @default.
- W2106450152 cites W2003477848 @default.
- W2106450152 cites W2006172403 @default.
- W2106450152 cites W2009739944 @default.
- W2106450152 cites W2015850083 @default.
- W2106450152 cites W2016950105 @default.
- W2106450152 cites W2017659306 @default.
- W2106450152 cites W2018412281 @default.
- W2106450152 cites W2021066750 @default.
- W2106450152 cites W2021403302 @default.
- W2106450152 cites W2024176341 @default.
- W2106450152 cites W2030571587 @default.
- W2106450152 cites W2034206425 @default.
- W2106450152 cites W2035276787 @default.
- W2106450152 cites W2039802164 @default.
- W2106450152 cites W2048165009 @default.
- W2106450152 cites W2050309247 @default.
- W2106450152 cites W2051025772 @default.
- W2106450152 cites W2057002012 @default.
- W2106450152 cites W2058891813 @default.
- W2106450152 cites W2062559638 @default.
- W2106450152 cites W2062956327 @default.
- W2106450152 cites W2062979344 @default.
- W2106450152 cites W2065134394 @default.
- W2106450152 cites W2071112954 @default.
- W2106450152 cites W2072151195 @default.
- W2106450152 cites W2075023881 @default.
- W2106450152 cites W2078286337 @default.
- W2106450152 cites W2079604770 @default.
- W2106450152 cites W2080513230 @default.
- W2106450152 cites W2083923976 @default.
- W2106450152 cites W2086189875 @default.
- W2106450152 cites W2086808432 @default.
- W2106450152 cites W2090441912 @default.
- W2106450152 cites W2091446347 @default.
- W2106450152 cites W2091791271 @default.
- W2106450152 cites W2092320644 @default.
- W2106450152 cites W2105296759 @default.
- W2106450152 cites W2118138635 @default.
- W2106450152 cites W2123758767 @default.
- W2106450152 cites W2124186983 @default.
- W2106450152 cites W2129935236 @default.
- W2106450152 cites W2132542247 @default.
- W2106450152 cites W2149233326 @default.
- W2106450152 cites W2155913937 @default.
- W2106450152 cites W2161855026 @default.
- W2106450152 cites W2162392926 @default.
- W2106450152 cites W2162537800 @default.
- W2106450152 cites W2170020593 @default.
- W2106450152 cites W2233443859 @default.
- W2106450152 cites W2303469300 @default.
- W2106450152 cites W2324992364 @default.
- W2106450152 cites W2393435276 @default.
- W2106450152 cites W2394901156 @default.
- W2106450152 cites W2412644635 @default.
- W2106450152 cites W2416007164 @default.
- W2106450152 cites W2418365690 @default.
- W2106450152 cites W27392726 @default.
- W2106450152 cites W3088642545 @default.
- W2106450152 cites W4251656321 @default.
- W2106450152 cites W994481069 @default.
- W2106450152 doi "https://doi.org/10.1155/2015/279356" @default.
- W2106450152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4600485" @default.
- W2106450152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26491566" @default.
- W2106450152 hasPublicationYear "2015" @default.
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