Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106451562> ?p ?o ?g. }
- W2106451562 endingPage "5360" @default.
- W2106451562 startingPage "5353" @default.
- W2106451562 abstract "A hyphally regulated gene (HYR1) from the dimorphic human pathogenic fungus Candida albicans was isolated and characterized. Northern (RNA) analyses showed that the HYR1 mRNA was induced specifically in response to hyphal development when morphogenesis was stimulated by serum addition and temperature elevation, increases in both culture pH and temperature, or N-acetylglucosamine addition. The HYR1 gene sequence revealed a 937-codon open reading frame capable of encoding a protein with an N-terminal signal sequence, a C-terminal glycosylphosphatidylinositol-anchoring domain, 17 potential N glycosylation sites, and a large domain rich in serine and threonine (51% of 230 residues). These features are observed in many yeast cell wall proteins, but no homologs are present in the databases. In addition, Hyr1p contained a second domain rich in glycine, serine, and asparagine (79% of 239 residues). The HYR1 locus in C. albicans CAI4 was disrupted by Ura-blasting, but the resulting homozygous delta hyr1/delta hyr1 null mutant displayed no obvious morphological phenotype. The growth rates for yeast cells and hyphae and the kinetics of germ tube formation in the null mutant were unaffected. Aberrant expression of HYR1 in yeast cells, when an ADH1-HYR1 fusion was used, did not stimulate hyphal formation in C. albicans or pseudohyphal growth in Saccharomyces cerevisiae. HYR1 appears to encode a nonessential component of the hyphal cell wall." @default.
- W2106451562 created "2016-06-24" @default.
- W2106451562 creator A5008227126 @default.
- W2106451562 creator A5031216816 @default.
- W2106451562 creator A5043101178 @default.
- W2106451562 creator A5048343791 @default.
- W2106451562 creator A5088735845 @default.
- W2106451562 date "1996-09-01" @default.
- W2106451562 modified "2023-10-11" @default.
- W2106451562 title "The Candida albicans HYR1 gene, which is activated in response to hyphal development, belongs to a gene family encoding yeast cell wall proteins" @default.
- W2106451562 cites W1490803640 @default.
- W2106451562 cites W1500428588 @default.
- W2106451562 cites W1512267178 @default.
- W2106451562 cites W1557224474 @default.
- W2106451562 cites W1609148190 @default.
- W2106451562 cites W1801962517 @default.
- W2106451562 cites W1815461608 @default.
- W2106451562 cites W1836452804 @default.
- W2106451562 cites W1872260506 @default.
- W2106451562 cites W1890684887 @default.
- W2106451562 cites W1906281896 @default.
- W2106451562 cites W1923660750 @default.
- W2106451562 cites W1923934287 @default.
- W2106451562 cites W1930313341 @default.
- W2106451562 cites W1936511155 @default.
- W2106451562 cites W1947722128 @default.
- W2106451562 cites W1960975851 @default.
- W2106451562 cites W1964548381 @default.
- W2106451562 cites W1968917541 @default.
- W2106451562 cites W1973782344 @default.
- W2106451562 cites W1985458133 @default.
- W2106451562 cites W1987409801 @default.
- W2106451562 cites W1990109619 @default.
- W2106451562 cites W1994136352 @default.
- W2106451562 cites W1997790108 @default.
- W2106451562 cites W1998871484 @default.
- W2106451562 cites W2009310436 @default.
- W2106451562 cites W2011602921 @default.
- W2106451562 cites W2014669590 @default.
- W2106451562 cites W2031516831 @default.
- W2106451562 cites W2041394937 @default.
- W2106451562 cites W2042161296 @default.
- W2106451562 cites W2043486052 @default.
- W2106451562 cites W2053847101 @default.
- W2106451562 cites W2062697778 @default.
- W2106451562 cites W2067503599 @default.
- W2106451562 cites W2068000163 @default.
- W2106451562 cites W2069030183 @default.
- W2106451562 cites W2072029215 @default.
- W2106451562 cites W2074882054 @default.
- W2106451562 cites W2082383071 @default.
- W2106451562 cites W2084021973 @default.
- W2106451562 cites W2084126259 @default.
- W2106451562 cites W2085418723 @default.
- W2106451562 cites W2087962856 @default.
- W2106451562 cites W2089819283 @default.
- W2106451562 cites W2094195202 @default.
- W2106451562 cites W2102470371 @default.
- W2106451562 cites W2108053853 @default.
- W2106451562 cites W2113880496 @default.
- W2106451562 cites W2114997878 @default.
- W2106451562 cites W2119437345 @default.
- W2106451562 cites W2125601441 @default.
- W2106451562 cites W2126409468 @default.
- W2106451562 cites W2128470405 @default.
- W2106451562 cites W2130316063 @default.
- W2106451562 cites W2133601682 @default.
- W2106451562 cites W2134210906 @default.
- W2106451562 cites W2138270253 @default.
- W2106451562 cites W2140935709 @default.
- W2106451562 cites W2143131708 @default.
- W2106451562 cites W2143806593 @default.
- W2106451562 cites W2144092679 @default.
- W2106451562 cites W2144212668 @default.
- W2106451562 cites W2148698017 @default.
- W2106451562 cites W2156701262 @default.
- W2106451562 cites W2160153791 @default.
- W2106451562 cites W2162015687 @default.
- W2106451562 cites W2168370663 @default.
- W2106451562 cites W2169032183 @default.
- W2106451562 cites W2176777897 @default.
- W2106451562 cites W2327110769 @default.
- W2106451562 cites W4254536048 @default.
- W2106451562 doi "https://doi.org/10.1128/jb.178.18.5353-5360.1996" @default.
- W2106451562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/178351" @default.
- W2106451562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8808922" @default.
- W2106451562 hasPublicationYear "1996" @default.
- W2106451562 type Work @default.
- W2106451562 sameAs 2106451562 @default.
- W2106451562 citedByCount "211" @default.
- W2106451562 countsByYear W21064515622012 @default.
- W2106451562 countsByYear W21064515622013 @default.
- W2106451562 countsByYear W21064515622014 @default.
- W2106451562 countsByYear W21064515622015 @default.
- W2106451562 countsByYear W21064515622016 @default.
- W2106451562 countsByYear W21064515622017 @default.
- W2106451562 countsByYear W21064515622018 @default.
- W2106451562 countsByYear W21064515622019 @default.