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• W2106455874 abstract "Abstract Leukemia inhibitory factor (LIF) is required to maintain pluripotency and permit self-renewal of murine embryonic stem (ES) cells. LIF binds to a receptor complex of LIFR-β and gp130 and signals via the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway, with signalling attenuated by suppressor of cytokine signalling (SOCS) proteins. Recent in vivo studies have highlighted the role of SOCS-3 in the negative regulation of signalling via gp130. To determine the role of SOCS-3 in ES cell biology, SOCS-3–null ES cell lines were generated. When cultured in LIF levels that sustain self-renewal of wild-type cells, SOCS-3–null ES cell lines exhibited less self-renewal and greater differentiation into primitive endoderm. The absence of SOCS-3 enhanced JAK–STAT and extracellular signal–related kinase 1/2 (ERK-1/2)–mitogen-activated protein kinase (MAPK) signal transduction via gp130, with higher levels of phosphorylated STAT-1, STAT-3, SH-2 domain–containing cytoplasmic protein tyrosine phosphatase 2 (SHP-2), and ERK-1/2 in steady state and in response to LIF stimulation. Attenuation of ERK signalling by the addition of MAPK/ERK kinase (MEK) inhibitors to SOCS-3–null ES cell cultures rescued the differentiation phenotype, but did not restore proliferation to wild-type levels. In summary, SOCS-3 plays a crucial role in the regulation of the LIF signalling pathway in murine ES cells. Its absence perturbs the balance between activation of the JAK–STAT and SHP-2–ERK-1/2–MAPK pathways, resulting in less self-renewal and a greater potential for differentiation into the primitive endoderm lineage." @default.
• W2106455874 created "2016-06-24" @default.
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• W2106455874 date "2005-08-25" @default.
• W2106455874 modified "2023-10-06" @default.
• W2106455874 title "Absence of Suppressor of Cytokine Signalling 3 Reduces Self-Renewal and Promotes Differentiation in Murine Embryonic Stem Cells" @default.
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• W2106455874 cites W1540169533 @default.
• W2106455874 cites W1562891803 @default.
• W2106455874 cites W1939561089 @default.
• W2106455874 cites W1965464733 @default.
• W2106455874 cites W1967258978 @default.
• W2106455874 cites W1972363513 @default.
• W2106455874 cites W1973607853 @default.
• W2106455874 cites W1987399378 @default.
• W2106455874 cites W1987803647 @default.
• W2106455874 cites W1988917700 @default.
• W2106455874 cites W1992160731 @default.
• W2106455874 cites W1992949513 @default.
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• W2106455874 cites W1997506291 @default.
• W2106455874 cites W2001773359 @default.
• W2106455874 cites W2003505321 @default.
• W2106455874 cites W2014660851 @default.
• W2106455874 cites W2015036988 @default.
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• W2106455874 cites W2038106655 @default.
• W2106455874 cites W2038468714 @default.
• W2106455874 cites W2040810264 @default.
• W2106455874 cites W2059592022 @default.
• W2106455874 cites W2064739359 @default.
• W2106455874 cites W2065786458 @default.
• W2106455874 cites W2066647113 @default.
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• W2106455874 cites W2072934943 @default.
• W2106455874 cites W2081098333 @default.
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• W2106455874 cites W2139020188 @default.
• W2106455874 cites W2140158862 @default.
• W2106455874 cites W2143297890 @default.
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• W2106455874 doi "https://doi.org/10.1634/stemcells.2005-0323" @default.
• W2106455874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16123385" @default.
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