Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106484407> ?p ?o ?g. }
- W2106484407 abstract "Well-characterized mice models will afford a cheaper, easy-handling opportunity for a more comprehensive understanding of 2009 influenza A (H1N1) virus’s pathogenesis potential. We aimed to provide a robust description of pulmonary immune responses in the mice infected by the virus. BALB/c mice were inoculated intranasally with A/Beijing/501/2009(H1N1) (BJ501) and A/PR/8/34(H1N1) (PR8) viruses and compared for survival rate, viral replication, and kinetics of pulmonary immune responses. BJ501 virus replicated less efficiently in the lungs than PR8, and both caused lethal illness in the mice. The transient increases of pulmonary TNF-α 2 days post infection for BJ501 and of INF-γ and IL-10 at 6 days post infection for PR8 were observed. IL-2+ and IL-4+ secreting cells showed significant increase 12 days post infection, while IFN-γ+, IgG+ and IgA+ secreting cells increased 6 days post infection. The different patterns of pulmonary immunological parameters between two viruses were at most seen in IL-6, IL-17 secretion and IgG1/IgG2a ratio. The BALB/c mouse is evaluated as a good pathogenic model for studying BJ501 2009 H1N1 virus. The work provided some basic and detailed data, which might be referred when further evaluating innate and adapted pulmonary immune responses and local viral load in mice." @default.
- W2106484407 created "2016-06-24" @default.
- W2106484407 creator A5000579179 @default.
- W2106484407 creator A5016241201 @default.
- W2106484407 creator A5017058735 @default.
- W2106484407 creator A5018244700 @default.
- W2106484407 creator A5042069966 @default.
- W2106484407 creator A5050211780 @default.
- W2106484407 creator A5058380236 @default.
- W2106484407 creator A5086418606 @default.
- W2106484407 creator A5091344960 @default.
- W2106484407 date "2014-04-12" @default.
- W2106484407 modified "2023-10-10" @default.
- W2106484407 title "Pulmonary immune responses to 2009 pandemic influenza A (H1N1) virus in mice" @default.
- W2106484407 cites W1480893694 @default.
- W2106484407 cites W1575690521 @default.
- W2106484407 cites W1608238667 @default.
- W2106484407 cites W1948268265 @default.
- W2106484407 cites W1974668319 @default.
- W2106484407 cites W1976680858 @default.
- W2106484407 cites W1987507585 @default.
- W2106484407 cites W1987783718 @default.
- W2106484407 cites W1989694037 @default.
- W2106484407 cites W1990123193 @default.
- W2106484407 cites W1991011893 @default.
- W2106484407 cites W1991159506 @default.
- W2106484407 cites W1992928750 @default.
- W2106484407 cites W2002194487 @default.
- W2106484407 cites W2007032789 @default.
- W2106484407 cites W2008078869 @default.
- W2106484407 cites W2017348279 @default.
- W2106484407 cites W2030879571 @default.
- W2106484407 cites W2031997312 @default.
- W2106484407 cites W2032583054 @default.
- W2106484407 cites W2034322984 @default.
- W2106484407 cites W2036989655 @default.
- W2106484407 cites W2039027344 @default.
- W2106484407 cites W2039782308 @default.
- W2106484407 cites W2041753380 @default.
- W2106484407 cites W2063407488 @default.
- W2106484407 cites W2076293109 @default.
- W2106484407 cites W2076819052 @default.
- W2106484407 cites W2093785176 @default.
- W2106484407 cites W2098349861 @default.
- W2106484407 cites W2107328689 @default.
- W2106484407 cites W2112120822 @default.
- W2106484407 cites W2112331687 @default.
- W2106484407 cites W2113246862 @default.
- W2106484407 cites W2117047064 @default.
- W2106484407 cites W2121593344 @default.
- W2106484407 cites W2124208765 @default.
- W2106484407 cites W2125756467 @default.
- W2106484407 cites W2125921830 @default.
- W2106484407 cites W2126623340 @default.
- W2106484407 cites W2137809958 @default.
- W2106484407 cites W2146769688 @default.
- W2106484407 cites W2148229843 @default.
- W2106484407 cites W2149533101 @default.
- W2106484407 cites W2151546806 @default.
- W2106484407 cites W2155253017 @default.
- W2106484407 cites W2155461063 @default.
- W2106484407 cites W2163726366 @default.
- W2106484407 cites W2169497667 @default.
- W2106484407 cites W2170434427 @default.
- W2106484407 doi "https://doi.org/10.1186/1471-2334-14-197" @default.
- W2106484407 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4002205" @default.
- W2106484407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24725777" @default.
- W2106484407 hasPublicationYear "2014" @default.
- W2106484407 type Work @default.
- W2106484407 sameAs 2106484407 @default.
- W2106484407 citedByCount "9" @default.
- W2106484407 countsByYear W21064844072015 @default.
- W2106484407 countsByYear W21064844072016 @default.
- W2106484407 countsByYear W21064844072018 @default.
- W2106484407 countsByYear W21064844072019 @default.
- W2106484407 countsByYear W21064844072021 @default.
- W2106484407 crossrefType "journal-article" @default.
- W2106484407 hasAuthorship W2106484407A5000579179 @default.
- W2106484407 hasAuthorship W2106484407A5016241201 @default.
- W2106484407 hasAuthorship W2106484407A5017058735 @default.
- W2106484407 hasAuthorship W2106484407A5018244700 @default.
- W2106484407 hasAuthorship W2106484407A5042069966 @default.
- W2106484407 hasAuthorship W2106484407A5050211780 @default.
- W2106484407 hasAuthorship W2106484407A5058380236 @default.
- W2106484407 hasAuthorship W2106484407A5086418606 @default.
- W2106484407 hasAuthorship W2106484407A5091344960 @default.
- W2106484407 hasBestOaLocation W21064844071 @default.
- W2106484407 hasConcept C126322002 @default.
- W2106484407 hasConcept C12914427 @default.
- W2106484407 hasConcept C140704245 @default.
- W2106484407 hasConcept C159047783 @default.
- W2106484407 hasConcept C190139176 @default.
- W2106484407 hasConcept C203014093 @default.
- W2106484407 hasConcept C2522874641 @default.
- W2106484407 hasConcept C2777546802 @default.
- W2106484407 hasConcept C2779134260 @default.
- W2106484407 hasConcept C3008058167 @default.
- W2106484407 hasConcept C524204448 @default.
- W2106484407 hasConcept C71924100 @default.
- W2106484407 hasConcept C86803240 @default.