FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106519005> ?p ?o ?g. }

• W2106519005 endingPage "220" @default.
• W2106519005 startingPage "207" @default.
• W2106519005 abstract "Barnidipine is one of a new generation of dihydropyridine calcium-channel blockers. Despite evidence of favorable effects on blood pressure (BP) and insulin sensitivity, this drug has rarely been tested in hypertensive patients with metabolic syndrome (MS).The aim of this study was to evaluate the effects of barnidipine on BP and left ventricular (LV) diastolic function in patients with hypertension and MS.Consecutive subjects aged 18 to 75 years with systolic BP (SBP) of 140 to 179 mm Hg and/or diastolic BP (DBP) of 90 to 109 mm Hg and MS (based on Adult Treatment Panel III criteria) were assessed for inclusion in the study. Lifestyle changes according to current guidelines were recommended and barnidipine monotherapy 10 mg daily was initiated. All patients entered a 2-week run-in period. After a 6-week treatment period, the daily dosage was doubled for the remainder of the study in patients whose BP remained uncontrolled (≥140/≥90 mm Hg). We assessed the glycolipidic profile and LV structure and function using standard Doppler and tissue Doppler imaging (TDI) echocardiography before and after 12 weeks of treatment. Ambulatory BP records and electrocardiographic and echocardiographic tracings were coded and shipped to a central laboratory for blinded analysis. Possible adverse events (AEs) were recorded at predetermined intervals throughout the follow-up period and at unplanned intervals whenever an AE became known to the investigators.Thirty-four consecutive patients were assessed for inclusion. Thirty consecutive patients (20 men, 10 women; mean {SD| age, 55.9 {10.3| years; 5 current smokers) were included in the study. At study entry, mean office SBP was 146 mm Hg, DBP was 87 mm Hg, and heart rate was 72 beats/min. At the study end, mean office SBP/DBP was <140/90 mm Hg in 20 patients (66.7%). From baseline to study end, 24-hour ambulatory BP decreased significantly by 12 and 8 mm Hg for SBP and DBP, respectively (both, P = 0.001). The smoothness index was 0.92 for SBP and 0.82 for DBP. Fasting plasma glucose concentration decreased significantly from 110 to 104 mg/dL (P = 0.001). Total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol concentrations did not change significantly. From baseline to study end, there were no significant changes in LV structure or systolic function (LV mass, 50.7 vs 50.6 g/ht(2.7); LV diastolic/systolic diameters, 47.50/29.80 vs 48.40/30.76 mm; wall motion score index, 1.0 vs 1.0; ejection fraction, 61% vs 60%), while the peak E/A velocity ratio on TDI increased from 1.078 to 1.245 (P = 0.009). No AEs (including AEs reflected by chemistry values) either unrelated or related to treatment were noted during the 12-week duration of the study.In these hypertensive patients with MS, a 12-week treatment period with barnidipine in addition to lifestyle modifications was associated with significant reductions in 24-hour BP and BP variability, reduction in plasma glucose concentration, and improvement in LV diastolic relaxation. No significant changes in lipid concentrations, LV structure, or systolic function were found." @default.
• W2106519005 created "2016-06-24" @default.
• W2106519005 creator A5043831233 @default.
• W2106519005 creator A5061764959 @default.
• W2106519005 creator A5073861649 @default.
• W2106519005 creator A5088322292 @default.
• W2106519005 creator A5089976379 @default.
• W2106519005 date "2008-06-01" @default.
• W2106519005 modified "2023-10-18" @default.
• W2106519005 title "Effects of barnidipine on blood pressure and left ventricular diastolic function in patients with hypertension and metabolic syndrome: A 12-week, open-label noncomparison study" @default.
• W2106519005 cites W1602804702 @default.
• W2106519005 cites W1975555631 @default.
• W2106519005 cites W1992141724 @default.
• W2106519005 cites W1992991039 @default.
• W2106519005 cites W2001101777 @default.
• W2106519005 cites W2001657480 @default.
• W2106519005 cites W2034367257 @default.
• W2106519005 cites W2040176746 @default.
• W2106519005 cites W2042293234 @default.
• W2106519005 cites W2051995148 @default.
• W2106519005 cites W2056095647 @default.
• W2106519005 cites W2071626971 @default.
• W2106519005 cites W2078807483 @default.
• W2106519005 cites W2081183027 @default.
• W2106519005 cites W2094172811 @default.
• W2106519005 cites W2097281653 @default.
• W2106519005 cites W2103714496 @default.
• W2106519005 cites W2120159188 @default.
• W2106519005 cites W2142110637 @default.
• W2106519005 cites W2159854507 @default.
• W2106519005 cites W2166447149 @default.
• W2106519005 cites W2167357373 @default.
• W2106519005 cites W2303651371 @default.
• W2106519005 cites W3191287943 @default.
• W2106519005 cites W4230870013 @default.
• W2106519005 cites W4249727000 @default.
• W2106519005 doi "https://doi.org/10.1016/j.curtheres.2008.06.003" @default.
• W2106519005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3969914" @default.
• W2106519005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24692799" @default.
• W2106519005 hasPublicationYear "2008" @default.
• W2106519005 type Work @default.
• W2106519005 sameAs 2106519005 @default.
• W2106519005 citedByCount "4" @default.
• W2106519005 countsByYear W21065190052015 @default.
• W2106519005 countsByYear W21065190052017 @default.
• W2106519005 crossrefType "journal-article" @default.
• W2106519005 hasAuthorship W2106519005A5043831233 @default.
• W2106519005 hasAuthorship W2106519005A5061764959 @default.
• W2106519005 hasAuthorship W2106519005A5073861649 @default.
• W2106519005 hasAuthorship W2106519005A5088322292 @default.
• W2106519005 hasAuthorship W2106519005A5089976379 @default.
• W2106519005 hasBestOaLocation W21065190051 @default.
• W2106519005 hasConcept C126322002 @default.
• W2106519005 hasConcept C149323552 @default.
• W2106519005 hasConcept C164705383 @default.
• W2106519005 hasConcept C197934379 @default.
• W2106519005 hasConcept C2777097880 @default.
• W2106519005 hasConcept C2780346441 @default.
• W2106519005 hasConcept C2781212610 @default.
• W2106519005 hasConcept C35785553 @default.
• W2106519005 hasConcept C519063684 @default.
• W2106519005 hasConcept C57900726 @default.
• W2106519005 hasConcept C71924100 @default.
• W2106519005 hasConcept C84393581 @default.
• W2106519005 hasConceptScore W2106519005C126322002 @default.
• W2106519005 hasConceptScore W2106519005C149323552 @default.
• W2106519005 hasConceptScore W2106519005C164705383 @default.
• W2106519005 hasConceptScore W2106519005C197934379 @default.
• W2106519005 hasConceptScore W2106519005C2777097880 @default.
• W2106519005 hasConceptScore W2106519005C2780346441 @default.
• W2106519005 hasConceptScore W2106519005C2781212610 @default.
• W2106519005 hasConceptScore W2106519005C35785553 @default.
• W2106519005 hasConceptScore W2106519005C519063684 @default.
• W2106519005 hasConceptScore W2106519005C57900726 @default.
• W2106519005 hasConceptScore W2106519005C71924100 @default.
• W2106519005 hasConceptScore W2106519005C84393581 @default.
• W2106519005 hasIssue "3" @default.
• W2106519005 hasLocation W21065190051 @default.
• W2106519005 hasLocation W21065190052 @default.
• W2106519005 hasLocation W21065190053 @default.
• W2106519005 hasLocation W21065190054 @default.
• W2106519005 hasOpenAccess W2106519005 @default.
• W2106519005 hasPrimaryLocation W21065190051 @default.
• W2106519005 hasRelatedWork W1535524930 @default.
• W2106519005 hasRelatedWork W1965119604 @default.
• W2106519005 hasRelatedWork W2106519005 @default.
• W2106519005 hasRelatedWork W2158231286 @default.
• W2106519005 hasRelatedWork W2171320903 @default.
• W2106519005 hasRelatedWork W2352785111 @default.
• W2106519005 hasRelatedWork W2414038239 @default.
• W2106519005 hasRelatedWork W2415472139 @default.
• W2106519005 hasRelatedWork W2417661182 @default.
• W2106519005 hasRelatedWork W2520048396 @default.
• W2106519005 hasVolume "69" @default.
• W2106519005 isParatext "false" @default.
• W2106519005 isRetracted "false" @default.
• W2106519005 magId "2106519005" @default.
• W2106519005 workType "article" @default.