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- W2106539295 abstract "The combination of effective mobilisation protocols and efficient use of apheresis machines has caused peripheral blood progenitor cells (PBPC) transplantation to grow rapidly. The development of apheresis technology has improved over the years. Today PBSC procedures have changed towards systems to minimise operator interaction and to reduce the collection of undesired cells such as polymorphonuclear cells and platelets using functionally closed, sterile environments for PBSC collection in keeping with Good Manufacturing Practice guidelines. Blood cell separators with continuous flow technique allow the processing of more blood than intermittent flow devices resulting in higher PBSC yields. Large volume leukapheresis with the processing of 3–4-fold donor’s/patient’s blood volume can increase the number of collected progenitor cells. Therefore, intermittent flow cell separators are indicated if only single vein access is available. Anticoagulant induced hypocalcaemia is an often observed side effect in long lasting PBPC harvesting and monitoring of electrolytes should be performed especially at the end of the apheresis procedure to supplement low levels of potassium, calcium or magnesium. Refinement and improvement of collection techniques continue to add to the armamentarium of current approaches for cancer and non-malignant conditions and will enable future strategies." @default.
- W2106539295 created "2016-06-24" @default.
- W2106539295 creator A5032989242 @default.
- W2106539295 date "2004-12-01" @default.
- W2106539295 modified "2023-09-29" @default.
- W2106539295 title "Apheresis techniques for collection of peripheral blood progenitor cells" @default.
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- W2106539295 doi "https://doi.org/10.1016/j.transci.2004.09.006" @default.
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