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• W2106539617 abstract "Strohmaier et al1Strohmaier K. Snyder E. DuBiner H. Adamsons I. The efficacy and safety of the dorzolamide-timolol combination versus the concomitant administration of its components.Ophthalmology. 1998; 105: 1936-1944Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar conclude that the intraocular pressure (IOP)-lowering effect of the dorzolamide-timolol combination is comparable to that of dorzolamide three times daily plus timolol twice daily. I cannot see that this conclusion is substantiated by their study. It is indicated in the study design that patients were instructed to administer the twice-daily medications at 8:30 am and bedtime, and the three-times-daily medications at 8:40 am, 2:30 pm, and bedtime. The exact time of “bedtime” is not stated, but let us assume that it is 10:30 pm.The IOP was measured before the morning dose (morning through 0 hour, which with the given assumption is 10 hours after the evening dose), as well as 2 and 8 hours later. Thus, the morning trough measurement is the same in the two dosing regimens. However, the time from the morning instillation to the bedtime instillation in the twice-daily regimen was about 14 hours, whereas the time from the 2:30 instillation to bedtime was 8 hours in the three-times-daily regimen.It is well known that dorzolamide as monotherapy should be given three times daily. In a previous paper, Strahlman et al2Strahlman E.R. Vogel R. Tipping R. Clineschmidt C.M. The use of dorzolamide and pilocarpine as adjunctive therapy to timolol in patients with elevated intraocular pressure. The Dorzolamide Additivity Study Group.Ophthalmology. 1996; 103: 1283-1293Abstract Full Text PDF PubMed Scopus (67) Google Scholar found an obvious decrease in effect for a dorzolamide-timolol combination from hour 10 to hour 12. To support the conclusion in the article of Strohmaier et al,1Strohmaier K. Snyder E. DuBiner H. Adamsons I. The efficacy and safety of the dorzolamide-timolol combination versus the concomitant administration of its components.Ophthalmology. 1998; 105: 1936-1944Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar they would have to show that the evening trough IOP in the twice-daily regimen (hour 14) is comparable to the evening trough in the three-times-daily regimen (hour 8). I doubt that this is the case. After all, glaucoma is a 24-hour disease. Strohmaier et al1Strohmaier K. Snyder E. DuBiner H. Adamsons I. The efficacy and safety of the dorzolamide-timolol combination versus the concomitant administration of its components.Ophthalmology. 1998; 105: 1936-1944Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar conclude that the intraocular pressure (IOP)-lowering effect of the dorzolamide-timolol combination is comparable to that of dorzolamide three times daily plus timolol twice daily. I cannot see that this conclusion is substantiated by their study. It is indicated in the study design that patients were instructed to administer the twice-daily medications at 8:30 am and bedtime, and the three-times-daily medications at 8:40 am, 2:30 pm, and bedtime. The exact time of “bedtime” is not stated, but let us assume that it is 10:30 pm. The IOP was measured before the morning dose (morning through 0 hour, which with the given assumption is 10 hours after the evening dose), as well as 2 and 8 hours later. Thus, the morning trough measurement is the same in the two dosing regimens. However, the time from the morning instillation to the bedtime instillation in the twice-daily regimen was about 14 hours, whereas the time from the 2:30 instillation to bedtime was 8 hours in the three-times-daily regimen. It is well known that dorzolamide as monotherapy should be given three times daily. In a previous paper, Strahlman et al2Strahlman E.R. Vogel R. Tipping R. Clineschmidt C.M. The use of dorzolamide and pilocarpine as adjunctive therapy to timolol in patients with elevated intraocular pressure. The Dorzolamide Additivity Study Group.Ophthalmology. 1996; 103: 1283-1293Abstract Full Text PDF PubMed Scopus (67) Google Scholar found an obvious decrease in effect for a dorzolamide-timolol combination from hour 10 to hour 12. To support the conclusion in the article of Strohmaier et al,1Strohmaier K. Snyder E. DuBiner H. Adamsons I. The efficacy and safety of the dorzolamide-timolol combination versus the concomitant administration of its components.Ophthalmology. 1998; 105: 1936-1944Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar they would have to show that the evening trough IOP in the twice-daily regimen (hour 14) is comparable to the evening trough in the three-times-daily regimen (hour 8). I doubt that this is the case. After all, glaucoma is a 24-hour disease. Dorzolamide-timolol combination versus concomitant administration of its components: authors’ replyOphthalmologyVol. 106Issue 6Preview Full-Text PDF" @default.
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• W2106539617 title "Dorzolamide-timolol combination versus concomitant administration of its components" @default.
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• W2106539617 doi "https://doi.org/10.1016/s0161-6420(99)90280-4" @default.
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