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• W2106543148 abstract "Abstract Activated T cells, isolated from animals that had rejected a tumor (E.G7‐OVA) expressing chicken ovalbumin, were labeled with citrated superparamagnetic iron oxide nanoparticles at an intracellular iron concentration of up to 0.5 pg/cell. Injection of these labeled T cells into animals bearing E.G7‐OVA tumors undergoing immune rejection resulted in tumor infiltration of these cells, which was detectable as a heterogeneous decrease in intensity in T 2 ‐weighted MR images. T‐cell infiltration was confirmed by immunohistochemical staining of tumor sections obtained postmortem and was shown to colocalize with iron that had been stained using Prussian blue. Tumor rejection was correlated with the uptake of labeled T cells, since the infiltration of labeled T cells was only observed in those tumors that went on to regress. This technique should assist in the elucidation of those factors that are important in mediating tumor immune rejection. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc." @default.
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• W2106543148 date "2005-11-07" @default.
• W2106543148 modified "2023-10-04" @default.
• W2106543148 title "Monitoring T‐lymphocyte trafficking in tumors undergoing immune rejection" @default.
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• W2106543148 doi "https://doi.org/10.1002/mrm.20717" @default.
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