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- W2106543443 abstract "The genetics of BCG-induced pulmonary granulomatous inflammation (PGI) and splenomegaly was studied by breeding experiments and by the use of BXD recombinant inbred (Rl) and allotype-congenic mice. Breeding studies indicated that the genetic control was multifactorial; this observation was confirmed using BXD Rl mice. In addition, studies with BXD Rl mice suggested that genes linked to the Igh complex influence responsiveness. The influence of the lgh-linked genes was studied further using allotype-congenic mice; SJL mice (Ighb) developed significantly greater PGI than their congenic partner, SJA/9 (Igha). Data from BALB.lg, CB-20, and BAB-14 mice suggested that lgh-linked genes influencing PGI were a considerable distance from Igh-1. Igh-linked genes that influence BCG-induced splenomegaly were located on the centrometric side of the Igh-1 locus. This was shown by data in which splenomegaly in BALB.Igb and CB-20, but not BAB-14, mice was significantly augmented over BALBIc mice. Further studies are necessary to understand the significance of these observations." @default.
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- W2106543443 date "1983-01-01" @default.
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- W2106543443 title "Genetic Control of BCG-Induced Granulomatous Inflammation in Mice" @default.
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- W2106543443 doi "https://doi.org/10.3109/01902148309061516" @default.
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