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- W2106546104 endingPage "563" @default.
- W2106546104 startingPage "552" @default.
- W2106546104 abstract "Vitamin B-12 deficiency (<148 pmol/L) is associated with adverse maternal and neonatal outcomes, including developmental anomalies, spontaneous abortions, preeclampsia, and low birth weight (<2500 g). The importance of adequate vitamin B-12 status periconceptionally and during pregnancy cannot be overemphasized, given its fundamental role in neural myelination, brain development, and growth. Infants born to vitamin B-12-deficient women may be at increased risk of neural tube closure defects, and maternal vitamin B-12 insufficiency (<200 pmol/L) can impair infant growth, psychomotor function, and brain development, which may be irreversible. However, the underlying causal mechanisms are unknown. This review was conducted to examine the evidence that links maternal vitamin B-12 status and perinatal outcomes. Despite the high prevalence of vitamin B-12 deficiency and associated risk of pregnancy complications, few prospective studies and, to our knowledge, only 1 randomized trial have examined the effects of vitamin B-12 supplementation during pregnancy. The role of vitamin B-12 in the etiology of adverse perinatal outcomes needs to be elucidated to inform public health interventions." @default.
- W2106546104 created "2016-06-24" @default.
- W2106546104 creator A5027619713 @default.
- W2106546104 creator A5052113600 @default.
- W2106546104 creator A5059785514 @default.
- W2106546104 date "2015-09-01" @default.
- W2106546104 modified "2023-10-18" @default.
- W2106546104 title "Vitamin B-12 and Perinatal Health" @default.
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