FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106550539> ?p ?o ?g. }

• W2106550539 endingPage "604" @default.
• W2106550539 startingPage "597" @default.
• W2106550539 abstract "The relation between metabolic and functional derangement in various cardiomyopathies has not been well characterized. This information was specifically sought in a spontaneous cardiomyopathic model. Metabolic and hemodynamic parameters were obtained in glucose-perfused beating hearts of 180-200-day-old cardiomyopathic Syrian hamsters and age-matched healthy animals. This period in the cardiomyopathic hamster lifetime is intermediary between the necrotic phase and the appearance of heart failure. We used 31P nuclear magnetic resonance spectroscopy to analyze energy metabolites and intracellular pH. Cardiomyopathic hamsters had significantly higher mole fraction values for inorganic phosphate, lower phosphocreatine mole fraction as well as lower phosphocreatine/inorganic phosphate and adenosine triphosphate/inorganic phosphate ratios. Analysis of pH indicated the presence of regions of increased acidity within the heart of myopathic hamsters. Cardiomyopathic hamsters also had significantly lower left ventricular pressure, coronary flow, and myocardial oxygen consumption. Separate groups of normal and myopathic hamsters were given verapamil for 24 hours (one injection of 4 mg/kg s.c. followed by 1.2 g/l in drinking water). Verapamil-treated myopathic hamsters had evidence of markedly improved mitochondrial function when compared with untreated animals. Left ventricular pressure and coronary flow rose to normal levels. Replacing glucose by pyruvate in the perfusate of myopathic hamsters results in a marked increase in left ventricular pressure, coronary flow, and oxygen consumption with a moderate rise in phosphocreatine. Thus, 180-200-day-old cardiomyopathic hamster heart is characterized by evidence of decreased mitochondrial function, by areas of increased acidity within the heart, and by reduced left ventricular function.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2106550539 created "2016-06-24" @default.
• W2106550539 creator A5010476812 @default.
• W2106550539 creator A5014909820 @default.
• W2106550539 creator A5019278782 @default.
• W2106550539 creator A5019827988 @default.
• W2106550539 creator A5022452323 @default.
• W2106550539 creator A5066704514 @default.
• W2106550539 creator A5069393683 @default.
• W2106550539 creator A5072799122 @default.
• W2106550539 date "1986-12-01" @default.
• W2106550539 modified "2023-09-27" @default.
• W2106550539 title "Evaluation of the hereditary Syrian hamster cardiomyopathy by 31P nuclear magnetic resonance spectroscopy: improvement after acute verapamil therapy." @default.
• W2106550539 cites W1973488385 @default.
• W2106550539 cites W1979082736 @default.
• W2106550539 cites W1981531583 @default.
• W2106550539 cites W1985412407 @default.
• W2106550539 cites W1986642034 @default.
• W2106550539 cites W1994594631 @default.
• W2106550539 cites W1998972480 @default.
• W2106550539 cites W2003918511 @default.
• W2106550539 cites W2019125365 @default.
• W2106550539 cites W2026798725 @default.
• W2106550539 cites W2027293476 @default.
• W2106550539 cites W2028294010 @default.
• W2106550539 cites W2028504454 @default.
• W2106550539 cites W2041681001 @default.
• W2106550539 cites W2048355048 @default.
• W2106550539 cites W2050587855 @default.
• W2106550539 cites W2057957398 @default.
• W2106550539 cites W2066937941 @default.
• W2106550539 cites W2081501644 @default.
• W2106550539 cites W2082187526 @default.
• W2106550539 cites W2083085161 @default.
• W2106550539 cites W2085485254 @default.
• W2106550539 cites W2087288832 @default.
• W2106550539 cites W2115197925 @default.
• W2106550539 cites W2124507273 @default.
• W2106550539 cites W2133144313 @default.
• W2106550539 cites W2163574015 @default.
• W2106550539 cites W2166169771 @default.
• W2106550539 cites W2340914253 @default.
• W2106550539 cites W4233355494 @default.
• W2106550539 cites W80888926 @default.
• W2106550539 doi "https://doi.org/10.1161/01.res.59.6.597" @default.
• W2106550539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3815756" @default.
• W2106550539 hasPublicationYear "1986" @default.
• W2106550539 type Work @default.
• W2106550539 sameAs 2106550539 @default.
• W2106550539 citedByCount "53" @default.
• W2106550539 countsByYear W21065505392013 @default.
• W2106550539 countsByYear W21065505392019 @default.
• W2106550539 crossrefType "journal-article" @default.
• W2106550539 hasAuthorship W2106550539A5010476812 @default.
• W2106550539 hasAuthorship W2106550539A5014909820 @default.
• W2106550539 hasAuthorship W2106550539A5019278782 @default.
• W2106550539 hasAuthorship W2106550539A5019827988 @default.
• W2106550539 hasAuthorship W2106550539A5022452323 @default.
• W2106550539 hasAuthorship W2106550539A5066704514 @default.
• W2106550539 hasAuthorship W2106550539A5069393683 @default.
• W2106550539 hasAuthorship W2106550539A5072799122 @default.
• W2106550539 hasBestOaLocation W21065505391 @default.
• W2106550539 hasConcept C126322002 @default.
• W2106550539 hasConcept C134018914 @default.
• W2106550539 hasConcept C185592680 @default.
• W2106550539 hasConcept C2777022698 @default.
• W2106550539 hasConcept C2778198053 @default.
• W2106550539 hasConcept C2778273184 @default.
• W2106550539 hasConcept C2778575167 @default.
• W2106550539 hasConcept C2778626300 @default.
• W2106550539 hasConcept C2778797674 @default.
• W2106550539 hasConcept C2779525107 @default.
• W2106550539 hasConcept C2986317502 @default.
• W2106550539 hasConcept C519063684 @default.
• W2106550539 hasConcept C71924100 @default.
• W2106550539 hasConcept C78085059 @default.
• W2106550539 hasConceptScore W2106550539C126322002 @default.
• W2106550539 hasConceptScore W2106550539C134018914 @default.
• W2106550539 hasConceptScore W2106550539C185592680 @default.
• W2106550539 hasConceptScore W2106550539C2777022698 @default.
• W2106550539 hasConceptScore W2106550539C2778198053 @default.
• W2106550539 hasConceptScore W2106550539C2778273184 @default.
• W2106550539 hasConceptScore W2106550539C2778575167 @default.
• W2106550539 hasConceptScore W2106550539C2778626300 @default.
• W2106550539 hasConceptScore W2106550539C2778797674 @default.
• W2106550539 hasConceptScore W2106550539C2779525107 @default.
• W2106550539 hasConceptScore W2106550539C2986317502 @default.
• W2106550539 hasConceptScore W2106550539C519063684 @default.
• W2106550539 hasConceptScore W2106550539C71924100 @default.
• W2106550539 hasConceptScore W2106550539C78085059 @default.
• W2106550539 hasIssue "6" @default.
• W2106550539 hasLocation W21065505391 @default.
• W2106550539 hasLocation W21065505392 @default.
• W2106550539 hasLocation W21065505393 @default.
• W2106550539 hasOpenAccess W2106550539 @default.
• W2106550539 hasPrimaryLocation W21065505391 @default.
• W2106550539 hasRelatedWork W1919322485 @default.
• W2106550539 hasRelatedWork W1991298163 @default.

• next