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- W2106563980 abstract "ABSTRACT α-Synuclein is a major component of Lewy bodies in Parkinson's disease. Although no signal sequence is apparent, α-synuclein expressed in Escherichia coli is mostly located in the periplasm. The possibilities that α-synuclein translocated into the periplasm across the inner membrane by the SecA or the Tat targeting route identified in bacteria and that α-synuclein was released through MscL were excluded. The signal recognition particle-dependent pathway is involved in the translocation of α-synuclein. The C-terminal 99-to-140 portion of the α-synuclein molecule plays a signal-like role for its translocation into the periplasm, cooperating with the central 61-to-95 section. The N-terminal 1-to-60 region is not required for this translocation." @default.
- W2106563980 created "2016-06-24" @default.
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- W2106563980 date "2007-04-01" @default.
- W2106563980 modified "2023-10-18" @default.
- W2106563980 title "Translocation of α-Synuclein Expressed in <i>Escherichia coli</i>" @default.
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- W2106563980 doi "https://doi.org/10.1128/jb.01406-06" @default.
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