Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106568596> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2106568596 abstract "We have studied the effects of rifampicin on the overnight 1-mg dexamethasone suppression test usually employed to exclude suspected Cushing's syndrome. Previous observations indicate that in humans, rifampicin profoundly attenuates the biological effects of hydrocortisol and prednisolone, probably by increasing the metabolism of these drugs in the liver. The study was carried out in 16 normal volunteers. All subjects had a normal overnight 1-mg dexamethasone suppression test (468 +/- 86 vs. 32 +/- 21 nmol/L; mean +/- SD). In 8 subjects treated with rifampicin (600 mg) for 10 days, the inhibitory effect of dexamethasone on serum cortisol was completely prevented (575 +/- 114 vs. 434 +/- 82). In the remaining 8 rifampicin-treated subjects, the inhibitory effect of 1, 2, or 3 mg dexamethasone on serum cortisol was not observed. When 4 mg dexamethasone were administered, the serum cortisol level was 193 nmol/L, above the expected normal suppression value. The plasma dexamethasone concentration was very low after rifampicin treatment (range, 1.2-4.8 nmol/L). We conclude that when patients are treated with rifampicin, the standard overnight dexamethasone suppression test not only has no diagnostic value, but can be very misleading." @default.
- W2106568596 created "2016-06-24" @default.
- W2106568596 creator A5002108870 @default.
- W2106568596 creator A5025190422 @default.
- W2106568596 date "1992-07-01" @default.
- W2106568596 modified "2023-09-25" @default.
- W2106568596 title "Abnormal overnight dexamethasone suppression test in subjects receiving rifampicin therapy." @default.
- W2106568596 cites W2008342410 @default.
- W2106568596 cites W2050891806 @default.
- W2106568596 cites W2056581476 @default.
- W2106568596 cites W2078387530 @default.
- W2106568596 cites W2086068617 @default.
- W2106568596 cites W2226961199 @default.
- W2106568596 cites W2326529318 @default.
- W2106568596 cites W2406142682 @default.
- W2106568596 doi "https://doi.org/10.1210/jcem.75.1.1619024" @default.
- W2106568596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1619024" @default.
- W2106568596 hasPublicationYear "1992" @default.
- W2106568596 type Work @default.
- W2106568596 sameAs 2106568596 @default.
- W2106568596 citedByCount "16" @default.
- W2106568596 countsByYear W21065685962014 @default.
- W2106568596 countsByYear W21065685962015 @default.
- W2106568596 countsByYear W21065685962017 @default.
- W2106568596 countsByYear W21065685962019 @default.
- W2106568596 countsByYear W21065685962020 @default.
- W2106568596 countsByYear W21065685962023 @default.
- W2106568596 crossrefType "journal-article" @default.
- W2106568596 hasAuthorship W2106568596A5002108870 @default.
- W2106568596 hasAuthorship W2106568596A5025190422 @default.
- W2106568596 hasConcept C126322002 @default.
- W2106568596 hasConcept C134018914 @default.
- W2106568596 hasConcept C142724271 @default.
- W2106568596 hasConcept C2776715498 @default.
- W2106568596 hasConcept C2776804153 @default.
- W2106568596 hasConcept C2778607973 @default.
- W2106568596 hasConcept C2778709874 @default.
- W2106568596 hasConcept C2780401358 @default.
- W2106568596 hasConcept C2780455818 @default.
- W2106568596 hasConcept C2781069245 @default.
- W2106568596 hasConcept C71924100 @default.
- W2106568596 hasConceptScore W2106568596C126322002 @default.
- W2106568596 hasConceptScore W2106568596C134018914 @default.
- W2106568596 hasConceptScore W2106568596C142724271 @default.
- W2106568596 hasConceptScore W2106568596C2776715498 @default.
- W2106568596 hasConceptScore W2106568596C2776804153 @default.
- W2106568596 hasConceptScore W2106568596C2778607973 @default.
- W2106568596 hasConceptScore W2106568596C2778709874 @default.
- W2106568596 hasConceptScore W2106568596C2780401358 @default.
- W2106568596 hasConceptScore W2106568596C2780455818 @default.
- W2106568596 hasConceptScore W2106568596C2781069245 @default.
- W2106568596 hasConceptScore W2106568596C71924100 @default.
- W2106568596 hasLocation W21065685961 @default.
- W2106568596 hasLocation W21065685962 @default.
- W2106568596 hasOpenAccess W2106568596 @default.
- W2106568596 hasPrimaryLocation W21065685961 @default.
- W2106568596 hasRelatedWork W1976129656 @default.
- W2106568596 hasRelatedWork W1988200312 @default.
- W2106568596 hasRelatedWork W2059061827 @default.
- W2106568596 hasRelatedWork W2066936911 @default.
- W2106568596 hasRelatedWork W2092979627 @default.
- W2106568596 hasRelatedWork W2101614058 @default.
- W2106568596 hasRelatedWork W2106568596 @default.
- W2106568596 hasRelatedWork W2117648884 @default.
- W2106568596 hasRelatedWork W2147991645 @default.
- W2106568596 hasRelatedWork W2326529318 @default.
- W2106568596 isParatext "false" @default.
- W2106568596 isRetracted "false" @default.
- W2106568596 magId "2106568596" @default.
- W2106568596 workType "article" @default.