FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106573601> ?p ?o ?g. }

• W2106573601 endingPage "663" @default.
• W2106573601 startingPage "660" @default.
• W2106573601 abstract "<b>Background: </b> The combination of a small pool of patients at any given time with the availability of many potential neuroprotective agents to be tested in ALS requires efficient phase II trial designs. <b>Objective: </b> To describe the design of the Clinical Trial of High Dose Coenzyme Q10 (CoQ10) in ALS (QALS study)—a phase II, randomized, placebo-controlled, double-blind, multicenter clinical trial. <b>Methods: </b> The study design features two stages. The first stage (dose selection) identifies which of two doses of CoQ10 (1800 mg or 2700 mg) is preferred using a selection procedure rather than a formal hypothesis test. The second stage (early efficacy test) compares the preferred dose of CoQ10 against placebo using a non-superiority or futility design. Data from patients assigned to the preferred dose of CoQ10 in the first stage are also used in the second stage. The primary outcome measure is the decline in Amyotrophic Lateral Sclerosis Functional Rating Scale–revised (ALSFRSr) score from baseline to 9 months. <b>Results: </b> The total sample size required is 185 patients, as compared to a much larger sample size estimated to be necessary using a conventional superiority design (total: 852 patients). The authors report a bias correction made necessary by the inclusion of patient data from the first stage in the second stage. <b>Conclusions: </b> Several features of the Clinical Trial of High Dose Coenzyme Q10 in ALS study design promote efficiency. These features may be beneficial in phase II trials in amyotrophic lateral sclerosis and other fields." @default.
• W2106573601 created "2016-06-24" @default.
• W2106573601 creator A5017185598 @default.
• W2106573601 creator A5030098273 @default.
• W2106573601 creator A5030377377 @default.
• W2106573601 creator A5065780198 @default.
• W2106573601 creator A5068055654 @default.
• W2106573601 creator A5068317168 @default.
• W2106573601 creator A5070593246 @default.
• W2106573601 creator A5073216870 @default.
• W2106573601 creator A5078078004 @default.
• W2106573601 creator A5079146663 @default.
• W2106573601 creator A5081809170 @default.
• W2106573601 date "2006-03-13" @default.
• W2106573601 modified "2023-10-16" @default.
• W2106573601 title "A two-stage design for a phase II clinical trial of coenzyme Q10 in ALS" @default.
• W2106573601 cites W1412344639 @default.
• W2106573601 cites W1965288387 @default.
• W2106573601 cites W1984037473 @default.
• W2106573601 cites W1991380795 @default.
• W2106573601 cites W1995838503 @default.
• W2106573601 cites W1998437790 @default.
• W2106573601 cites W1998970893 @default.
• W2106573601 cites W2001221763 @default.
• W2106573601 cites W2002676470 @default.
• W2106573601 cites W2008305405 @default.
• W2106573601 cites W2017888144 @default.
• W2106573601 cites W2034456343 @default.
• W2106573601 cites W2062321724 @default.
• W2106573601 cites W2065353775 @default.
• W2106573601 cites W2071510501 @default.
• W2106573601 cites W2108381339 @default.
• W2106573601 cites W2112853966 @default.
• W2106573601 cites W2122094983 @default.
• W2106573601 cites W2141403362 @default.
• W2106573601 cites W2145330051 @default.
• W2106573601 cites W2149744053 @default.
• W2106573601 cites W2155631934 @default.
• W2106573601 cites W2161938104 @default.
• W2106573601 cites W2402987424 @default.
• W2106573601 cites W2404482258 @default.
• W2106573601 cites W2468552662 @default.
• W2106573601 doi "https://doi.org/10.1212/01.wnl.0000201182.60750.66" @default.
• W2106573601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16534103" @default.
• W2106573601 hasPublicationYear "2006" @default.
• W2106573601 type Work @default.
• W2106573601 sameAs 2106573601 @default.
• W2106573601 citedByCount "94" @default.
• W2106573601 countsByYear W21065736012012 @default.
• W2106573601 countsByYear W21065736012013 @default.
• W2106573601 countsByYear W21065736012014 @default.
• W2106573601 countsByYear W21065736012015 @default.
• W2106573601 countsByYear W21065736012016 @default.
• W2106573601 countsByYear W21065736012017 @default.
• W2106573601 countsByYear W21065736012018 @default.
• W2106573601 countsByYear W21065736012019 @default.
• W2106573601 countsByYear W21065736012020 @default.
• W2106573601 countsByYear W21065736012021 @default.
• W2106573601 countsByYear W21065736012022 @default.
• W2106573601 crossrefType "journal-article" @default.
• W2106573601 hasAuthorship W2106573601A5017185598 @default.
• W2106573601 hasAuthorship W2106573601A5030098273 @default.
• W2106573601 hasAuthorship W2106573601A5030377377 @default.
• W2106573601 hasAuthorship W2106573601A5065780198 @default.
• W2106573601 hasAuthorship W2106573601A5068055654 @default.
• W2106573601 hasAuthorship W2106573601A5068317168 @default.
• W2106573601 hasAuthorship W2106573601A5070593246 @default.
• W2106573601 hasAuthorship W2106573601A5073216870 @default.
• W2106573601 hasAuthorship W2106573601A5078078004 @default.
• W2106573601 hasAuthorship W2106573601A5079146663 @default.
• W2106573601 hasAuthorship W2106573601A5081809170 @default.
• W2106573601 hasConcept C105795698 @default.
• W2106573601 hasConcept C126322002 @default.
• W2106573601 hasConcept C129848803 @default.
• W2106573601 hasConcept C142724271 @default.
• W2106573601 hasConcept C146357865 @default.
• W2106573601 hasConcept C151730666 @default.
• W2106573601 hasConcept C168563851 @default.
• W2106573601 hasConcept C203092338 @default.
• W2106573601 hasConcept C204787440 @default.
• W2106573601 hasConcept C27081682 @default.
• W2106573601 hasConcept C2779134260 @default.
• W2106573601 hasConcept C2779384338 @default.
• W2106573601 hasConcept C2780596555 @default.
• W2106573601 hasConcept C33923547 @default.
• W2106573601 hasConcept C535046627 @default.
• W2106573601 hasConcept C71924100 @default.
• W2106573601 hasConcept C86803240 @default.
• W2106573601 hasConceptScore W2106573601C105795698 @default.
• W2106573601 hasConceptScore W2106573601C126322002 @default.
• W2106573601 hasConceptScore W2106573601C129848803 @default.
• W2106573601 hasConceptScore W2106573601C142724271 @default.
• W2106573601 hasConceptScore W2106573601C146357865 @default.
• W2106573601 hasConceptScore W2106573601C151730666 @default.
• W2106573601 hasConceptScore W2106573601C168563851 @default.
• W2106573601 hasConceptScore W2106573601C203092338 @default.
• W2106573601 hasConceptScore W2106573601C204787440 @default.
• W2106573601 hasConceptScore W2106573601C27081682 @default.

• next