FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106574562> ?p ?o ?g. }

• W2106574562 endingPage "138" @default.
• W2106574562 startingPage "133" @default.
• W2106574562 abstract "Hyperthermic stress is known to trigger the loss of unicellular algae from a number of symbiotic cnidarians, a phenomenon commonly referred to as bleaching. Oxidative and nitrosative stress have been suggested to play a major role during the process of bleaching, however the underlying molecular mechanisms are still poorly understood. In animals, the intracellular tripeptide glutathione (GSH) is involved in antioxidant defense, redox homeostasis and intracellular redox signaling. Therefore, we tested the hypothesis that hyperthermal stress-induced bleaching in Aiptasia pallida, a model for symbiotic cnidarians, results in increased levels of GSH synthesis. We report the cDNA sequence and functional analysis of the catalytic subunit of glutamate-cysteine ligase (GCLC), which catalyzes the rate-limiting step in GSH biosynthesis. In a time-series experiment, both GCLC gene expression and total GSH levels increased 4- and 1.5-fold, respectively, in response to hyperthermal stress. These results suggest that hyperthermal stress triggers adaptive increases in intracellular GSH biosynthesis in cnidarians as a protective response to oxidative/nitrosative stress. Our results show the conserved function of GCLC and GSH across animals while placing a new perspective on the role of GSH in redox signaling during cnidarian bleaching." @default.
• W2106574562 created "2016-06-24" @default.
• W2106574562 creator A5022255793 @default.
• W2106574562 creator A5027144722 @default.
• W2106574562 creator A5036366314 @default.
• W2106574562 creator A5077204648 @default.
• W2106574562 date "2008-09-01" @default.
• W2106574562 modified "2023-10-16" @default.
• W2106574562 title "Hyperthermic stress-induced increase in the expression of glutamate-cysteine ligase and glutathione levels in the symbiotic sea anemone Aiptasia pallida" @default.
• W2106574562 cites W1970457841 @default.
• W2106574562 cites W2005493046 @default.
• W2106574562 cites W2006295617 @default.
• W2106574562 cites W2009745570 @default.
• W2106574562 cites W2014928920 @default.
• W2106574562 cites W2015045796 @default.
• W2106574562 cites W2017200992 @default.
• W2106574562 cites W2018027837 @default.
• W2106574562 cites W2020560563 @default.
• W2106574562 cites W2027474412 @default.
• W2106574562 cites W2034389240 @default.
• W2106574562 cites W2041629346 @default.
• W2106574562 cites W2042515533 @default.
• W2106574562 cites W2065463296 @default.
• W2106574562 cites W2067948282 @default.
• W2106574562 cites W2070269147 @default.
• W2106574562 cites W2073703119 @default.
• W2106574562 cites W2076641266 @default.
• W2106574562 cites W2089195402 @default.
• W2106574562 cites W2094302444 @default.
• W2106574562 cites W2111608731 @default.
• W2106574562 cites W2114868510 @default.
• W2106574562 cites W2117818477 @default.
• W2106574562 cites W2118564574 @default.
• W2106574562 cites W2118808586 @default.
• W2106574562 cites W2120259837 @default.
• W2106574562 cites W2127535576 @default.
• W2106574562 cites W2130235101 @default.
• W2106574562 cites W2132028628 @default.
• W2106574562 cites W2132029227 @default.
• W2106574562 cites W2134156897 @default.
• W2106574562 cites W2140963209 @default.
• W2106574562 cites W2142544974 @default.
• W2106574562 cites W2164428407 @default.
• W2106574562 cites W2170531650 @default.
• W2106574562 cites W2183661319 @default.
• W2106574562 cites W2464341179 @default.
• W2106574562 cites W49713821 @default.
• W2106574562 doi "https://doi.org/10.1016/j.cbpb.2008.06.007" @default.
• W2106574562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2732428" @default.
• W2106574562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18602489" @default.
• W2106574562 hasPublicationYear "2008" @default.
• W2106574562 type Work @default.
• W2106574562 sameAs 2106574562 @default.
• W2106574562 citedByCount "30" @default.
• W2106574562 countsByYear W21065745622012 @default.
• W2106574562 countsByYear W21065745622013 @default.
• W2106574562 countsByYear W21065745622014 @default.
• W2106574562 countsByYear W21065745622015 @default.
• W2106574562 countsByYear W21065745622016 @default.
• W2106574562 countsByYear W21065745622017 @default.
• W2106574562 countsByYear W21065745622018 @default.
• W2106574562 countsByYear W21065745622019 @default.
• W2106574562 countsByYear W21065745622020 @default.
• W2106574562 countsByYear W21065745622021 @default.
• W2106574562 crossrefType "journal-article" @default.
• W2106574562 hasAuthorship W2106574562A5022255793 @default.
• W2106574562 hasAuthorship W2106574562A5027144722 @default.
• W2106574562 hasAuthorship W2106574562A5036366314 @default.
• W2106574562 hasAuthorship W2106574562A5077204648 @default.
• W2106574562 hasBestOaLocation W21065745622 @default.
• W2106574562 hasConcept C181199279 @default.
• W2106574562 hasConcept C2776151105 @default.
• W2106574562 hasConcept C2779881523 @default.
• W2106574562 hasConcept C2781173740 @default.
• W2106574562 hasConcept C538909803 @default.
• W2106574562 hasConcept C55493867 @default.
• W2106574562 hasConcept C79879829 @default.
• W2106574562 hasConcept C86803240 @default.
• W2106574562 hasConcept C95444343 @default.
• W2106574562 hasConceptScore W2106574562C181199279 @default.
• W2106574562 hasConceptScore W2106574562C2776151105 @default.
• W2106574562 hasConceptScore W2106574562C2779881523 @default.
• W2106574562 hasConceptScore W2106574562C2781173740 @default.
• W2106574562 hasConceptScore W2106574562C538909803 @default.
• W2106574562 hasConceptScore W2106574562C55493867 @default.
• W2106574562 hasConceptScore W2106574562C79879829 @default.
• W2106574562 hasConceptScore W2106574562C86803240 @default.
• W2106574562 hasConceptScore W2106574562C95444343 @default.
• W2106574562 hasIssue "1" @default.
• W2106574562 hasLocation W21065745621 @default.
• W2106574562 hasLocation W21065745622 @default.
• W2106574562 hasLocation W21065745623 @default.
• W2106574562 hasLocation W21065745624 @default.
• W2106574562 hasOpenAccess W2106574562 @default.
• W2106574562 hasPrimaryLocation W21065745621 @default.
• W2106574562 hasRelatedWork W2028766244 @default.
• W2106574562 hasRelatedWork W2037765035 @default.
• W2106574562 hasRelatedWork W2083165373 @default.

• next