FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106591775> ?p ?o ?g. }

• W2106591775 endingPage "322" @default.
• W2106591775 startingPage "317" @default.
• W2106591775 abstract "Ethanol decreases the clearance of cocaine by inhibiting the hydrolysis of cocaine to benzoylecgonine and ecgonine methyl ester by carboxylesterases, and there is a large body of literature describing this interaction as it relates to the abuse of cocaine. In this study, we describe the effect of intravenous ethanol on the pharmacokinetics of cocaine after intravenous and oral administration in the dog. The intent is to determine the effect ethanol has on metabolic hydrolysis using cocaine metabolism as a surrogate marker of carboxylesterase activity. Five dogs were administered intravenous cocaine alone, intravenous cocaine after ethanol, oral cocaine alone, and oral cocaine after ethanol on separate study days. Cocaine, benzoylecgonine, and cocaethylene concentrations were determined by high-performance liquid chromatography. Cocaine had poor systemic bioavailability with an area under the plasma concentration-time curve that was approximately 4-fold higher after intravenous than after oral administration. The coadministration of ethanol and cocaine resulted in a 23% decrease in the clearance of intravenous cocaine and a 300% increase in the bioavailability of oral cocaine. Cocaine behaves as a high extraction drug, which undergoes first-pass metabolism in the intestines and liver that is profoundly inhibited by ethanol. We infer from these results that ethanol could inhibit the hydrolysis of other drug compounds subject to hydrolysis by carboxylesterases. Indeed, there are numerous commonly prescribed drugs with significant carboxylesterase-mediated metabolism such as enalapril, lovastatin, irinotecan, clopidogrel, prasugrel, methylphenidate, meperidine, and oseltamivir that may interact with ethanol. The clinical significance of the interaction of ethanol with specific drugs subject to carboxylesterase hydrolysis is not well recognized and has not been adequately studied." @default.
• W2106591775 created "2016-06-24" @default.
• W2106591775 creator A5065915958 @default.
• W2106591775 creator A5068954371 @default.
• W2106591775 date "2009-11-17" @default.
• W2106591775 modified "2023-10-04" @default.
• W2106591775 title "The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions" @default.
• W2106591775 cites W159470118 @default.
• W2106591775 cites W1809000693 @default.
• W2106591775 cites W1964749595 @default.
• W2106591775 cites W1966737506 @default.
• W2106591775 cites W1971008344 @default.
• W2106591775 cites W1974472082 @default.
• W2106591775 cites W1976074072 @default.
• W2106591775 cites W1980011643 @default.
• W2106591775 cites W1992261389 @default.
• W2106591775 cites W1994168507 @default.
• W2106591775 cites W1996281157 @default.
• W2106591775 cites W2007304817 @default.
• W2106591775 cites W2021476495 @default.
• W2106591775 cites W2026215813 @default.
• W2106591775 cites W2031720996 @default.
• W2106591775 cites W2038854993 @default.
• W2106591775 cites W2039642744 @default.
• W2106591775 cites W2040441365 @default.
• W2106591775 cites W2049103398 @default.
• W2106591775 cites W2060291899 @default.
• W2106591775 cites W2060435731 @default.
• W2106591775 cites W2061230362 @default.
• W2106591775 cites W2067590520 @default.
• W2106591775 cites W2073631823 @default.
• W2106591775 cites W2081460129 @default.
• W2106591775 cites W2090067165 @default.
• W2106591775 cites W2103067782 @default.
• W2106591775 cites W2122628099 @default.
• W2106591775 cites W2136934702 @default.
• W2106591775 cites W2141256777 @default.
• W2106591775 cites W2141262525 @default.
• W2106591775 cites W2148633205 @default.
• W2106591775 cites W2156890309 @default.
• W2106591775 cites W2161672948 @default.
• W2106591775 cites W2168795101 @default.
• W2106591775 cites W2315913162 @default.
• W2106591775 cites W2319708680 @default.
• W2106591775 cites W2411214613 @default.
• W2106591775 cites W3023828467 @default.
• W2106591775 doi "https://doi.org/10.1124/dmd.109.030056" @default.
• W2106591775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2812060" @default.
• W2106591775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19920055" @default.
• W2106591775 hasPublicationYear "2009" @default.
• W2106591775 type Work @default.
• W2106591775 sameAs 2106591775 @default.
• W2106591775 citedByCount "36" @default.
• W2106591775 countsByYear W21065917752012 @default.
• W2106591775 countsByYear W21065917752013 @default.
• W2106591775 countsByYear W21065917752014 @default.
• W2106591775 countsByYear W21065917752015 @default.
• W2106591775 countsByYear W21065917752016 @default.
• W2106591775 countsByYear W21065917752017 @default.
• W2106591775 countsByYear W21065917752018 @default.
• W2106591775 countsByYear W21065917752019 @default.
• W2106591775 countsByYear W21065917752020 @default.
• W2106591775 countsByYear W21065917752021 @default.
• W2106591775 countsByYear W21065917752022 @default.
• W2106591775 crossrefType "journal-article" @default.
• W2106591775 hasAuthorship W2106591775A5065915958 @default.
• W2106591775 hasAuthorship W2106591775A5068954371 @default.
• W2106591775 hasBestOaLocation W21065917752 @default.
• W2106591775 hasConcept C112705442 @default.
• W2106591775 hasConcept C181199279 @default.
• W2106591775 hasConcept C181389837 @default.
• W2106591775 hasConcept C185592680 @default.
• W2106591775 hasConcept C201253974 @default.
• W2106591775 hasConcept C2777056448 @default.
• W2106591775 hasConcept C2777477808 @default.
• W2106591775 hasConcept C2777537440 @default.
• W2106591775 hasConcept C2778325069 @default.
• W2106591775 hasConcept C2780035454 @default.
• W2106591775 hasConcept C2780161600 @default.
• W2106591775 hasConcept C55493867 @default.
• W2106591775 hasConcept C71924100 @default.
• W2106591775 hasConcept C97320921 @default.
• W2106591775 hasConcept C98274493 @default.
• W2106591775 hasConceptScore W2106591775C112705442 @default.
• W2106591775 hasConceptScore W2106591775C181199279 @default.
• W2106591775 hasConceptScore W2106591775C181389837 @default.
• W2106591775 hasConceptScore W2106591775C185592680 @default.
• W2106591775 hasConceptScore W2106591775C201253974 @default.
• W2106591775 hasConceptScore W2106591775C2777056448 @default.
• W2106591775 hasConceptScore W2106591775C2777477808 @default.
• W2106591775 hasConceptScore W2106591775C2777537440 @default.
• W2106591775 hasConceptScore W2106591775C2778325069 @default.
• W2106591775 hasConceptScore W2106591775C2780035454 @default.
• W2106591775 hasConceptScore W2106591775C2780161600 @default.
• W2106591775 hasConceptScore W2106591775C55493867 @default.
• W2106591775 hasConceptScore W2106591775C71924100 @default.
• W2106591775 hasConceptScore W2106591775C97320921 @default.
• W2106591775 hasConceptScore W2106591775C98274493 @default.

• next