FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106602217> ?p ?o ?g. }

• W2106602217 abstract "In recent years, the development of transgenic and gene targeting technologies have made the mouse a powerful model to dissect the contribution of various genes to lipoprotein metabolism and atherosclerosis susceptibility. Here, murine bone marrow transplantation (BMT) is presented as a method to investigate the role of the macrophage in lipoprotein metabolism and atherosclerosis. This approach has been successfully implemented in apolipoprotein (apo) E-deficient mice, which develop severe hyperlipidemia and extensive aortic and coronary atherosclerosis. BMT was performed as a way to deliver macrophages with the normal complement of the apoE gene to the apoE-deficient mice. BMT resulted in the appearance of apoE in plasma, in a sustained drop in cholesterol levels, and in the normalization of the lipoprotein profile. In addition, BMT protected the apoE-deficient mice from diet-induced hypercholesterolemia and atherosclerosis. These data demonstrate that extrahepatic apoE secreted into the plasma compartment is functionally active and promotes lipoprotein clearance, and establish BMT as a novel approach to dissecting the role of macrophages in atherosclerosis and lipid metabolism. In addition, these findings show that the liver is not the obligatory target organ in gene therapy of dyslipidemia, and suggest the use of the macrophage as a vehicle." @default.
• W2106602217 created "2016-06-24" @default.
• W2106602217 creator A5067797353 @default.
• W2106602217 creator A5089000198 @default.
• W2106602217 date "1996-02-01" @default.
• W2106602217 modified "2023-09-27" @default.
• W2106602217 title "Murine bone marrow transplantation as a novel approach to studying the role of macrophages in lipoprotein metabolism and atherogenesis" @default.
• W2106602217 cites W1492043593 @default.
• W2106602217 cites W1509027462 @default.
• W2106602217 cites W1509384892 @default.
• W2106602217 cites W1571838620 @default.
• W2106602217 cites W1574438828 @default.
• W2106602217 cites W1578152528 @default.
• W2106602217 cites W1620258338 @default.
• W2106602217 cites W170055736 @default.
• W2106602217 cites W171024714 @default.
• W2106602217 cites W1859624620 @default.
• W2106602217 cites W1900087291 @default.
• W2106602217 cites W1961244064 @default.
• W2106602217 cites W1964814612 @default.
• W2106602217 cites W1968283484 @default.
• W2106602217 cites W1968347471 @default.
• W2106602217 cites W1976331883 @default.
• W2106602217 cites W1978975731 @default.
• W2106602217 cites W1981725024 @default.
• W2106602217 cites W1986783707 @default.
• W2106602217 cites W1992309287 @default.
• W2106602217 cites W2008692985 @default.
• W2106602217 cites W2014721239 @default.
• W2106602217 cites W2017319919 @default.
• W2106602217 cites W2020711578 @default.
• W2106602217 cites W2023685895 @default.
• W2106602217 cites W2024016245 @default.
• W2106602217 cites W2028841673 @default.
• W2106602217 cites W2034968148 @default.
• W2106602217 cites W2035252462 @default.
• W2106602217 cites W2045437638 @default.
• W2106602217 cites W2048400898 @default.
• W2106602217 cites W2048890665 @default.
• W2106602217 cites W2056245899 @default.
• W2106602217 cites W2056800449 @default.
• W2106602217 cites W2067963408 @default.
• W2106602217 cites W2078828132 @default.
• W2106602217 cites W2088163556 @default.
• W2106602217 cites W2110668734 @default.
• W2106602217 cites W2115309238 @default.
• W2106602217 cites W2128186576 @default.
• W2106602217 cites W2134010411 @default.
• W2106602217 cites W2137570167 @default.
• W2106602217 cites W2139266365 @default.
• W2106602217 cites W2142403172 @default.
• W2106602217 cites W2148896104 @default.
• W2106602217 cites W2151426663 @default.
• W2106602217 cites W2162458714 @default.
• W2106602217 cites W2169149496 @default.
• W2106602217 cites W2276906655 @default.
• W2106602217 doi "https://doi.org/10.1016/1050-1738(96)00007-2" @default.
• W2106602217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21232276" @default.
• W2106602217 hasPublicationYear "1996" @default.
• W2106602217 type Work @default.
• W2106602217 sameAs 2106602217 @default.
• W2106602217 citedByCount "15" @default.
• W2106602217 countsByYear W21066022172012 @default.
• W2106602217 countsByYear W21066022172020 @default.
• W2106602217 crossrefType "journal-article" @default.
• W2106602217 hasAuthorship W2106602217A5067797353 @default.
• W2106602217 hasAuthorship W2106602217A5089000198 @default.
• W2106602217 hasConcept C102230213 @default.
• W2106602217 hasConcept C104317684 @default.
• W2106602217 hasConcept C126322002 @default.
• W2106602217 hasConcept C134018914 @default.
• W2106602217 hasConcept C141035611 @default.
• W2106602217 hasConcept C202751555 @default.
• W2106602217 hasConcept C203014093 @default.
• W2106602217 hasConcept C2778096610 @default.
• W2106602217 hasConcept C2778163477 @default.
• W2106602217 hasConcept C2779091943 @default.
• W2106602217 hasConcept C2779134260 @default.
• W2106602217 hasConcept C2779244956 @default.
• W2106602217 hasConcept C2780007613 @default.
• W2106602217 hasConcept C2780072125 @default.
• W2106602217 hasConcept C2911091166 @default.
• W2106602217 hasConcept C4733338 @default.
• W2106602217 hasConcept C511355011 @default.
• W2106602217 hasConcept C55493867 @default.
• W2106602217 hasConcept C555293320 @default.
• W2106602217 hasConcept C57089818 @default.
• W2106602217 hasConcept C62746215 @default.
• W2106602217 hasConcept C71924100 @default.
• W2106602217 hasConcept C86803240 @default.
• W2106602217 hasConceptScore W2106602217C102230213 @default.
• W2106602217 hasConceptScore W2106602217C104317684 @default.
• W2106602217 hasConceptScore W2106602217C126322002 @default.
• W2106602217 hasConceptScore W2106602217C134018914 @default.
• W2106602217 hasConceptScore W2106602217C141035611 @default.
• W2106602217 hasConceptScore W2106602217C202751555 @default.
• W2106602217 hasConceptScore W2106602217C203014093 @default.
• W2106602217 hasConceptScore W2106602217C2778096610 @default.
• W2106602217 hasConceptScore W2106602217C2778163477 @default.
• W2106602217 hasConceptScore W2106602217C2779091943 @default.

• next