FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2106603973> ?p ?o ?g. }

• W2106603973 endingPage "4436" @default.
• W2106603973 startingPage "4427" @default.
• W2106603973 abstract "The goal of this study was to investigate the in vitro-in vivo correlation (IVIVC) for fenofibrate immediate release (IR) tablet formulations based on MeltDose®-technique. The in vitro determined drug solubility and permeability data were related to the Cmax values observed from two in vivo human studies. Solubility and permeation studies of fenofibrate were conducted in medium simulating the fasted state conditions in the upper jejunum, containing the surfactant compositions of the six formulations at different concentrations. The behavior of all surfactant compositions was characterized by surface tension, dynamic light scattering, and cryo-TEM. The obtained solubility and permeation data were combined and compared with the Cmax values for the fenofibrate formulations, assuming a 50 mL in vivo dissolution volume. A good IVIVC was observed for five fenofibrate formulations (R2=0.94). The in vitro studies revealed that the formulation compositions containing sodium lauryl sulfate (SLS) interfered with the vesicular drug solubilizing system of the biorelevant medium and antagonized its solubilization capacity. The opposing interaction of surfactants with the emulsifying physiological constituents in intestinal juice should be taken into consideration in order to prevent unsatisfactory in vivo performance of orally administered formulations with low soluble active pharmaceutical ingredients." @default.
• W2106603973 created "2016-06-24" @default.
• W2106603973 creator A5007186343 @default.
• W2106603973 creator A5019621504 @default.
• W2106603973 creator A5045380616 @default.
• W2106603973 creator A5047209991 @default.
• W2106603973 creator A5059490056 @default.
• W2106603973 creator A5059523693 @default.
• W2106603973 creator A5078955304 @default.
• W2106603973 date "2010-10-01" @default.
• W2106603973 modified "2023-10-02" @default.
• W2106603973 title "IVIVC for Fenofibrate Immediate Release Tablets Using Solubility and Permeability as In Vitro Predictors for Pharmacokinetics" @default.
• W2106603973 cites W1499768710 @default.
• W2106603973 cites W1964480472 @default.
• W2106603973 cites W1979196526 @default.
• W2106603973 cites W2011204030 @default.
• W2106603973 cites W2011707100 @default.
• W2106603973 cites W2014768059 @default.
• W2106603973 cites W2028021263 @default.
• W2106603973 cites W2034575409 @default.
• W2106603973 cites W2051732279 @default.
• W2106603973 cites W2081373833 @default.
• W2106603973 cites W2082816879 @default.
• W2106603973 cites W2126738960 @default.
• W2106603973 cites W2134798108 @default.
• W2106603973 cites W2172249541 @default.
• W2106603973 doi "https://doi.org/10.1002/jps.22148" @default.
• W2106603973 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20737642" @default.
• W2106603973 hasPublicationYear "2010" @default.
• W2106603973 type Work @default.
• W2106603973 sameAs 2106603973 @default.
• W2106603973 citedByCount "35" @default.
• W2106603973 countsByYear W21066039732012 @default.
• W2106603973 countsByYear W21066039732013 @default.
• W2106603973 countsByYear W21066039732014 @default.
• W2106603973 countsByYear W21066039732015 @default.
• W2106603973 countsByYear W21066039732016 @default.
• W2106603973 countsByYear W21066039732017 @default.
• W2106603973 countsByYear W21066039732018 @default.
• W2106603973 countsByYear W21066039732019 @default.
• W2106603973 countsByYear W21066039732021 @default.
• W2106603973 countsByYear W21066039732023 @default.
• W2106603973 crossrefType "journal-article" @default.
• W2106603973 hasAuthorship W2106603973A5007186343 @default.
• W2106603973 hasAuthorship W2106603973A5019621504 @default.
• W2106603973 hasAuthorship W2106603973A5045380616 @default.
• W2106603973 hasAuthorship W2106603973A5047209991 @default.
• W2106603973 hasAuthorship W2106603973A5059490056 @default.
• W2106603973 hasAuthorship W2106603973A5059523693 @default.
• W2106603973 hasAuthorship W2106603973A5078955304 @default.
• W2106603973 hasConcept C112705442 @default.
• W2106603973 hasConcept C14029885 @default.
• W2106603973 hasConcept C150903083 @default.
• W2106603973 hasConcept C155574463 @default.
• W2106603973 hasConcept C178790620 @default.
• W2106603973 hasConcept C185592680 @default.
• W2106603973 hasConcept C207001950 @default.
• W2106603973 hasConcept C22979827 @default.
• W2106603973 hasConcept C2778110834 @default.
• W2106603973 hasConcept C2779484521 @default.
• W2106603973 hasConcept C2781430271 @default.
• W2106603973 hasConcept C41625074 @default.
• W2106603973 hasConcept C43617362 @default.
• W2106603973 hasConcept C50670333 @default.
• W2106603973 hasConcept C55493867 @default.
• W2106603973 hasConcept C58226133 @default.
• W2106603973 hasConcept C71924100 @default.
• W2106603973 hasConcept C86803240 @default.
• W2106603973 hasConcept C98274493 @default.
• W2106603973 hasConceptScore W2106603973C112705442 @default.
• W2106603973 hasConceptScore W2106603973C14029885 @default.
• W2106603973 hasConceptScore W2106603973C150903083 @default.
• W2106603973 hasConceptScore W2106603973C155574463 @default.
• W2106603973 hasConceptScore W2106603973C178790620 @default.
• W2106603973 hasConceptScore W2106603973C185592680 @default.
• W2106603973 hasConceptScore W2106603973C207001950 @default.
• W2106603973 hasConceptScore W2106603973C22979827 @default.
• W2106603973 hasConceptScore W2106603973C2778110834 @default.
• W2106603973 hasConceptScore W2106603973C2779484521 @default.
• W2106603973 hasConceptScore W2106603973C2781430271 @default.
• W2106603973 hasConceptScore W2106603973C41625074 @default.
• W2106603973 hasConceptScore W2106603973C43617362 @default.
• W2106603973 hasConceptScore W2106603973C50670333 @default.
• W2106603973 hasConceptScore W2106603973C55493867 @default.
• W2106603973 hasConceptScore W2106603973C58226133 @default.
• W2106603973 hasConceptScore W2106603973C71924100 @default.
• W2106603973 hasConceptScore W2106603973C86803240 @default.
• W2106603973 hasConceptScore W2106603973C98274493 @default.
• W2106603973 hasIssue "10" @default.
• W2106603973 hasLocation W21066039731 @default.
• W2106603973 hasLocation W21066039732 @default.
• W2106603973 hasOpenAccess W2106603973 @default.
• W2106603973 hasPrimaryLocation W21066039731 @default.
• W2106603973 hasRelatedWork W2006335639 @default.
• W2106603973 hasRelatedWork W2055974197 @default.
• W2106603973 hasRelatedWork W2057097799 @default.
• W2106603973 hasRelatedWork W2106603973 @default.
• W2106603973 hasRelatedWork W2129915229 @default.

• next