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- W2106604531 abstract "Bidisomide is a Class Ia/Ib antiarrhythmic agent with activity against ventricular and supraventricular arrhythmias. The potential for bidisomide to increase defibrillation threshold (DFT) was tested in anesthetized dogs with healed left ventricular infards (≥ 10 days). Defibrillation patches were attached to each ventricle and shocks were delivered via an external cardioverter/defibrillator. Three groups were studied: placebo (saline), canine therapeutic bidisomide (TB, 2–5 μg/mL plasma concentration) and supratherapeutic bidisomide (STB, 6–14 μg/mL). Each animal received only one treatment. An abbreviated DFT curve was determined before and after treatment. Heart rate, blood pressure, PR, QRS, infarct size, and hematocrit were also measured be/ore and after treatment. DFT was significantly increased (average + 3 to +5 joules [J], P < 0.05) by TB and STB. TB (5/5) did not increase DFT beyond 40 J. In 6/7 experiments, STB did not increase DFT beyond 40 J. Placebo (n = 6) had no significant effect on DFT. Infarct size (x = 11% of the left ventricle) was not significantly different between groups. Heart rate and QRS were not significantly altered but blood pressure was significantly decreased (16%-31% systolic, 29%-45% diastolic) and hematocrit was significantly increased (19% to 25%) in oil groups. PR was significantly increased by STB only. Conclusion: therapeutic and supratherapeutic doses of bidisomide slightly but significantly increased DFT (3–5 J) in a canine infarcted heart model." @default.
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- W2106604531 date "1993-02-01" @default.
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- W2106604531 title "The Effect of Bidisomide (SC-40230), a New Class Ia/Ib Antiarrhythmic Agent, on Defihrillation Energy Requirements in Dogs with Healed Myocardial Infarctions" @default.
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- W2106604531 doi "https://doi.org/10.1111/j.1540-8159.1993.tb01583.x" @default.
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